Effect of age on cutaneous vasoconstrictor responses to norepinephrine in humans

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 5 56-5, 2004, Pages

  Wilson, Thad E ^a   Monahan, Kevin D ^a   Short, Daniel S ^a   Ray, Chester A ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

adrenergic receptors; Cold stress; Intradermal microdialysis

Indexed keywords

BRETYLIUM TOSYLATE; NORADRENALIN;

ADULT; AGED; ARTICLE; CLINICAL PROTOCOL; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HUMAN; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; NORADRENALIN RELEASE; NORADRENERGIC NERVE; NORMAL HUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN BLOOD VESSEL; SKIN TEMPERATURE; SPECIES COMPARISON; STATISTICAL SIGNIFICANCE; VASOCONSTRICTION;

NASA DISCIPLINE CARDIOPULMONARY; NON-NASA CENTER;

ADOLESCENT; ADRENERGIC AGENTS; ADULT; AGED; AGING; BRETYLIUM TOSYLATE; COLD; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MICRODIALYSIS; MIDDLE AGED; NOREPINEPHRINE; REGIONAL BLOOD FLOW; SKIN; STRESS; VASOCONSTRICTOR AGENTS;

EID: 6344249185     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00467.2004     Document Type: Article

References (36)

1. Budd GM, Brotherhood JR, Hendrie AL, and Jeffery SE. Effects of fitness, fatness, and age on men's responses to whole body cooling in air. J Appl Physiol 71: 2387-2393, 1991.
2. Collins KJ and Exton-Smith AN. 1983 Henderson Award Lecture: Thermal homeostasis in old age. J Am Geriatr Soc 31: 519-524, 1983.
3. Detry JM, Brengelmann GL, Rowell LB, and Wyss C. Skin and muscle components of forearm blood flow in directly heated resting man. J Appl Physiol 32: 506-511, 1972.
4. Dinenno FA, Dietz NM, and Joyner MJ. Aging and forearm postjunctional α-adrenergic vasoconstriction in healthy men. Circulation 106: 1349-1354, 2002.
5. Docherty JR. Age-related changes in adrenergic neuroeffector transmission. Auton Neurosci 96: 8-12, 2002.
6. Falk B, Bar-Or O, Smolander J, and Frost G. Response to rest and exercise in the cold: effects of age and aerobic fitness. J Appl Physiol 76: 72-78, 1994.
7. Frank SM, el-Gamal N, Raja SN, and Wu PK. α-Adrenoceptor mechanisms of thermoregulation during cold challenge in humans. Clin Sci (Lond) 91: 627-631, 1996.
8. Grassi G, Seravalle G, Turri C, Bertinieri G, Dell'Oro R, and Mancia G. Impairment of thermoregulatory control of skin sympathetic nerve traffic in the elderly. Circulation 108: 729-735, 2003.
9. Hogikyan RV and Supiano MA. Arterial α-adrenergic responsiveness is decreased and SNS activity is increased in older humans. Am J Physiol Endocrinol Metab 266: E717-E724, 1994.
10. Inoue Y, Havenith G, Kenney WL, Loomis JL, and Buskirk ER. Exercise- and methylcholine-induced sweating responses in older and younger men: effect of heat acclimation and aerobic fitness. Int J Biometeorol 42: 210-216, 1999.
11. Kellogg DL Jr, Johnson JM, and Kosiba WA. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am J Physiol Heart Circ Physiol 257: H1599-H1606, 1989.
12. Kenney WL. Control of heat-induced cutaneous vasodilatation in relation to age. Eur J Appl Physiol Occup Physiol 57: 120-125, 1988.
13. Kenney WL and Armstrong CG. Reflex peripheral vasoconstriction is diminished in older men. J Appl Physiol 80: 512-515, 1996.
14. Kenney WL and Munce TA. Aging and human temperature regulation. J Appl Physiol 95: 2598-2603, 2003.
15. Khan F, Spence VA, and Belch JJ. Cutaneous vascular responses and thermoregulation in relation to age. Clin Sci (Lond) 82: 521-528, 1992.
16. Khan MH, Sinoway LI, and MacLean DA. Effects of graded LBNP on MSNA and interstitial norepinephrine. Am J Physiol Heart Circ Physiol 283: H2038-H2044, 2002.
17. Martin HL, Loomis JL, and Kenney WL. Maximal skin vascular conductance in subjects aged 5-85 yr. J Appl Physiol 79: 297-301, 1995.
18. Mathew L, Purkayastha SS, Singh R, and Sen Gupta J. Influence of aging in the thermoregulatory efficiency of man. Int J Biometeorol 30: 137-145, 1986.
19. Minson CT, Holowatz LA, Wong BJ, Kenney WL, and Wilkins BW. Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating. J Appl Physiol 93: 1644-1649, 2002.
20. Ng AV, Callister R, Johnson DG, and Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 21: 498-503, 1993.
21. Pergola PE, Johnson JM, Kellogg DL Jr, and Kosiba WA. Control of skin blood flow by whole body and local skin cooling in exercising humans. Am J Physiol Heart Circ Physiol 270: H208-H215, 1996.
22. Pergola PE, Kellogg DL, Johnson JM, Kosiba WA, and Solomon DE. Role of sympathetic nerves in the vascular effects of local temperature in human forearm skin. Am J Physiol Heart Circ Physiol 265: H785-H792, 1993.
23. Ray CA and Monahan KD. Aging attenuates the vestibulosympathetic reflex in humans. Circulation 105: 956-961, 2002.
24. Rooke GA, Savage MV, and Brengelmann GL. Maximal skin blood flow is decreased in elderly men. J Appl Physiol 77: 11-14, 1994.
25. Seals DR and Esler MS. Human ageing and the sympathoadrenal system. J Physiol 528: 407-417, 2000.
26. Stephens DP, Aoki K, Kosiba WA, and Johnson JM. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol 280: H1496-H1504, 2001.
27. Stephens DP, Bennett LA, Aoki K, Kosiba WA, Charkoudian N, and Johnson JM. Sympathetic nonnoradrenergic cutaneous vasoconstriction in women is associated with reproductive hormone status. Am J Physiol Heart Circ Physiol 282: H264-H272, 2002.
28. Stephens DP, Saad AR, Bennett LT, Kosiba WA, and Johnson JM. Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans. Am J Physiol Heart Circ Physiol 287: H1404-H1409, 2004.
29. Thompson CS and Kenney WL. Altered neurotransmitter control of reflex vasoconstriction in aged human skin. J Physiol 558: 697-704, 2004.
30. Vanhoutte PM, Verbeuren TJ, and Webb RC. Local modulation of adrenergic neuroeffector interaction in the blood vessel well. Physiol Rev 61: 151-247, 1981.
31. Wagner JA and Horvath SM. Influences of age and gender on human thermoregulatory responses to cold exposures. J Appl Physiol 58: 180-186, 1985.
32. Wilson TE, Cui J, and Crandall CG. Effect of whole-body and local heating on cutaneous vasoconstrictor responses in humans. Auton Neurosci 97: 122-128, 2002.
33. Wilson TE, Shibasaki M, Cui J, Levine BD, and Crandall CG. Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans. J Appl Physiol 94: 2113-2118, 2003.
34. Young AJ. Effects of aging on human cold tolerance. Exp Aging Res 17: 205-213, 1991.
35. Yousef MK and Golding LA. Thermal homeostasis and aging. In: Milestones in Environmental Physiology, edited by Yousef MK. Hague, The Netherlands: SPB Academic, 1989, p. 53-61.
36. Ziegler MG, Lake CR, and Kopin IJ. Plasma noradrenaline increases with age. Nature 261: 333-335, 1976.