PPARγ and colon and rectal cancer: Associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)

Cancer Causes and Control

Volumn 17, Issue 3, 2006, Pages 239-249

  Slattery, Martha L ^a   Curtin, Karen ^a   Wolff, Roger ^a   Ma, Khe Ni ^a   Sweeney, Carol ^a   Murtaugh, Maureen ^a   Potter, John D ^b   Levin, Theodore R ^c   Samowitz, Wade ^d  

^a UNIVERSITY OF UTAH   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c KAISER PERMANENTE   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Aspirin; Colorectal cancer; Insulin; NSAIDs; PPAR

Indexed keywords

ACETYLSALICYLIC ACID; ANACIN; ASCRIPTIN; BAYER; BUFFRIN; EXCEDRIN; IBUPROFEN; INSULIN; NAPROXEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIROXICAM; SULINDAC; VANGUISH; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; AGED; ARTICLE; CANCER RISK; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG USE; EVALUATION; FEMALE; GENE INTERACTION; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; RECTUM CANCER; RISK REDUCTION; CASE CONTROL STUDY; COLON TUMOR; GENETICS; MIDDLE AGED; MUTATION; RECTUM TUMOR; RISK; UNITED STATES;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CALIFORNIA; CASE-CONTROL STUDIES; COLONIC NEOPLASMS; FEMALE; GENOTYPE; HUMANS; IBUPROFEN; INSULIN; MALE; MIDDLE AGED; MINNESOTA; MUTATION; ODDS RATIO; POLYMORPHISM, GENETIC; PPAR GAMMA; RECTAL NEOPLASMS; UTAH;

EID: 32944454770     PISSN: 09575243     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10552-005-0411-6     Document Type: Article

References (69)

1. I Barroso M Gurnell VE Crowley 1999 Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension Nature 402 880 883
2. Y Guan Y Zhang MD Breyer 2002 The Role of PPARs in the Transcriptional Control of Cellular Processes Drug News Perspect 15 147 154
3. M Gurnell JM Wentworth M Agostini 2000 A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis J Biol Chem 275 5754 5759
4. W He Y Barak A Hevener 2003 Adipose-specific peroxisome proliferator-activated receptor {gamma} knockout causes insulin resistance in fat and liver but not in muscle PNAS 100 15712 15717
5. Y Tamori J Masugi N Nishino M Kasuga 2002 Role of peroxisome proliferator-activated receptor-{gamma} in maintenance of the characteristics of mature 3T3-L1 adipocytes Diabetes 51 2045 2055
6. E Saez P Tontonoz MC Nelson 1998 Activators of the nuclear receptor PPARgamma enhance colon polyp formation Nat Med 4 1058 1061
7. L Fajas D Auboeuf E Raspe 1997 The organization, promoter analysis, and expression of the human PPARgamma gene J Biol Chem 272 18779 18789
8. M Lefebvre B Paulweber L Fajas 1999 Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells J Endocrinol 162 331 340
9. AM Lefebvre I Chen P Desreumaux 1998 Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice Nat Med 4 1053 1057
10. J Berger DE Moller 2002 The mechanisms of action of PPARs Annu Rev Med 53 409 435
11. DE Moller JP Berger 2003 Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation Int J Obes Relat Metab Disord 27 Suppl 3 S17 S21
12. JM Rhodes BJ Campbell 2002 Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared Trends Mol Med 8 10 16
13. SH Itzkowitz X Yio 2004 Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation Am J Physiol Gastrointest Liver Physiol 287 G7 G17
14. T Tanaka H Kohno S Yoshitani 2001 Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats Cancer Res 61 2424 2428
15. SS Deeb L Fajas M Nemoto 1998 A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity Nat Genet 20 284 287
16. GD Girnun WM Smith S Drori 2002 APC-dependent suppression of colon carcinogenesis by PPARgamma Proc Natl Acad Sci USA 99 13771 13776
17. M Nagamine T Okumura S Tanno 2003 PPAR gamma ligand-induced apoptosis through a p53-dependent mechanism in human gastric cancer cells Cancer Sci 94 338 343
18. M Gurnell 2003 PPARgamma and metabolism: insights from the study of human genetic variants Clin Endocrinol (Oxf) 59 267 277
19. ML Slattery J Potter B Caan 1997 Energy balance and colon cancer - beyond physical activity Cancer Res 57 75 80
20. FB Hu JE Manson S Liu 1999 Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women J Natl Cancer Inst 91 542 547
21. E Giovannucci 1995 Insulin and colon cancer Cancer Causes Control 6 164 179
22. D Komninou A Ayonote JP Richie Jr. B Rigas 2003 Insulin resistance and its contribution to colon carcinogenesis Exp Biol Med (Maywood) 228 396 405
23. E Giovannucci 2003 Diet, body weight, and colorectal cancer: a summary of the epidemiologic evidence J Womens Health (Larchmt) 12 173 182
24. S Landi V Moreno L Gioia-Patricola 2003 Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer Cancer Res 63 3560 3566
25. M Stumvoll H Haring 2001 Insulin resistance and insulin sensitizers Horm Res 55 Suppl 2 3 13
26. BW Ogunkolade BJ Boucher JM Prahl 2002 Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians Diabetes 51 2294 2300
27. F Rozen M Pollak 1999 Inhibition of insulin-like growth factor I receptor signaling by the vitamin D analogue EB1089 in MCF-7 breast cancer cells: a role for insulin-like growth factor binding proteins Int J Oncol 15 589 594
28. CJ Rosen ES Kurland D Vereault 1998 Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density J Clin Endocrinol Metab 83 2286 2290
29. J Ma MN Pollak E Giovannucci 1999 Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3 J Natl Cancer Inst 91 620 625
30. P Kovacs RL Hanson Y-H Lee 2003 The Role of Insulin Receptor Substrate-1 Gene (IRS1) in Type 2 Diabetes in Pima Indians Diabetes 52 3005 3009
31. C Lautier SA El Mkadem E Renard 2003 Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation Hum Genet 113 34 43
32. S Nagpal J Lu MF Boehm 2001 Vitamin D analogs: mechanism of action and therapeutic applications Curr Med Chem 8 1661 1679
33. CE Hayes FE Nashold KM Spach LB Pedersen 2003 The immunological functions of the vitamin D endocrine system Cell Mol Biol (Noisy-le-grand) 49 277 300
34. S Edwards ML Slattery M Mori 1994 Objective system for interviewer performance evaluation for use in epidemiologic studies Am J Epidemiol 140 1020 1028
35. ML Slattery BJ Caan D Duncan TD Berry A Coates R Kerber 1994 A computerized diet history questionnaire for epidemiologic studies J Am Diet Assoc 94 761 766
36. K Liu M Slattery D Jacobs Jr. 1994 A study of the reliability and comparative validity of the cardia dietary history Ethn Dis 4 15 27
37. DA Ehrmann X Tang I Yoshiuchi NJ Cox GI Bell 2002 Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome J Clin Endocrinol Metab 87 4297 4300
38. C Deal J Ma F Wilkin 2001 Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators J Clin Endocrinol Metab 86 1274 1280
39. ML Slattery K Yakumo M Hoffman S Neuhausen 2001 Variants of the VDR gene and risk of colon cancer (United States) Cancer Causes Control 12 359 364
40. SA Ingles RK Ross MC Yu 1997 Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor J Natl Cancer Inst 89 166 170
41. JE Curran T Vaughan RA Lea SR Weinstein NA Morrison LR Griffiths 1999 Association of A vitamin D receptor polymorphism with sporadic breast cancer development Int J Cancer 83 723 726
42. ML Slattery SL Edwards L Palmer 2000 Use of archival tissue in epidemiologic studies: collection procedures and assessment of potential sources of bias Mutat Res 432 7 14
43. ML Slattery K Curtin K Ma 2002 Diet activity, and lifestyle associations with p53 mutations in colon tumors Cancer Epidemiol Biomarkers Prev 11 541 548
44. ML Slattery K Anderson K Curtin 2001 Lifestyle factors and Ki-ras mutations in colon cancer tumors Mutat Res 483 73 81
45. ML Slattery K Curtin K Anderson 2000 Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors J Natl Cancer Inst 92 1831 1836
46. DW Hosmer S Lemeshow 1992 Confidence interval estimation of interaction Epidemiology 3 452 456
47. AS Doney B Fischer JE Cecil 2004 Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes Diabetologia 47 555 558
48. SM Rangwala B Rhoades JS Shapiro 2003 Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity Dev Cell 5 657 663
49. M Hara SY Alcoser A Qaadir KK Beiswenger NJ Cox DA Ehrmann 2002 Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene J Clin Endocrinol Metab 87 772 775
50. A Doney B Fischer D Frew 2002 Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight BMC Genet 3 21
51. PM Ridker NR Cook S Cheng 2003 Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction Arterioscler Thromb Vasc Biol 23 859 863
52. ML Slattery W Samowitz K Curtin 2004 Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer Cancer Epidemiol Biomarkers Prev 13 1206 1214
53. K Curtin ML Slattery S Edwards JA Holden Ws Samowitz 2004 p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry Appl Immunohistochem Mol Morphol 12 380 386
54. ML Slattery K Anderson K Curtin KN Ma D Schaffer W Samowitz 2001 Dietary intake and microsatellite instability in colon tumors Int J Cancer 93 601 607
55. LJ Marnett 1992 Aspirin and the potential role of prostaglandins in colon cancer Cancer Research 52 5575 5589
56. JB Nixon H Kamitani SJ Baek TE Eling 2003 Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells Prostag Leukotr Essent Fatty Acids 68 323 330
57. H Kojo M Fukagawa K Tajima 2003 Evaluation of human peroxisome proliferator-activated receptor (PPAR) subtype selectivity of a variety of anti-inflammatory drugs based on a novel assay for PPAR delta (beta) J Pharmacol Sci 93 347 355
58. I Tegeder J Pfeilschifter G Geisslinger 2001 Cyclooxygenase-independent actions of cyclooxygenase inhibitors Faseb J 15 2057 2072
59. A Suzuki T Yasuno H Kojo J Hirosumi S Mutoh Y Notsu 2000 Alteration in expression profiles of a series of diabetes-related genes in db/db mice following treatment with thiazolidinediones Jpn J Pharmacol 84 113 123
60. C Deal J Ma F Wilkin 2001 Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators J Clin Endocrinol Metab 86 1274 1280
61. NP Michell S Dent MJ Langman MC Eggo 1997 Insulin-like growth factor binding proteins as mediators of IGF-I effects on colon cancer cell proliferation Growth Factors 14 269 277
62. ML Slattery BJ Caan J Benson M Murtaugh 2003 Energy balance and rectal cancer: an evaluation of energy intake, energy expenditure, and body mass index Nutr Cancer 46 166 171
63. SA Ingles J Wang GA Coetzee ER Lee HD Frankl RW Haile 2001 Vitamin D receptor polymorphisms and risk of colorectal adenomas (United States) Cancer Causes Control 12 607 614
64. HS Kim PA Newcomb CM Ulrich 2001 Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium Cancer Epidemiol Biomarkers Prev 10 869 874
65. PW Jurutka LS Remus GK Whitfield 2000 The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB Mol Endocrinol 14 401 420
66. AV Krishnan D Feldman 1991 Stimulation of 1,25-dihydroxyvitamin D3 receptor gene expression in cultured cells by serum and growth factors J Bone Miner Res 6 1099 1107
67. P Sarraf E Mueller D Jones 1998 Differentiation and reversal of malignant changes in colon cancer through PPARgamma Nat Med 4 1046 1052
68. W Smalley WA Ray J Daugherty MR Griffin 1999 Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer: a population-based study Arch Intern Med 159 161 166
69. E Giovannucci KM Egan DJ Hunter 1995 Aspirin and the risk of colorectal cancer in women N Engl J Med 333 609 614