메뉴 건너뛰기




Volumn 11, Issue 1 P.1-446, 2006, Pages 46-58

Ii-Key/MHC class II epitope peptides as helper T cell vaccines for cancer and infectious disease

Author keywords

Immune system; Immunity; Immunotherapy; Invariant chain; MHC class II; Review

Indexed keywords


EID: 32844473600     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1779     Document Type: Review
Times cited : (9)

References (72)
  • 1
    • 0023176825 scopus 로고
    • An hypothesis on the binding of an amphipathic, alpha helical sequence in Ii to the desetope of class II antigens
    • Elliott W. L., C. J. Stille, L. J. Thomas & R. E. Humphreys: An hypothesis on the binding of an amphipathic, alpha helical sequence in Ii to the desetope of class II antigens. J Immunol 138, 2949-52 (1987)
    • (1987) J Immunol , vol.138 , pp. 2949-2952
    • Elliott, W.L.1    Stille, C.J.2    Thomas, L.J.3    Humphreys, R.E.4
  • 2
    • 0024589213 scopus 로고
    • Time course of intracellular associations, processing, and cleavages of Ii forms and class II major histocompatibility complex molecules
    • Nguyen Q. V. & R. E. Humphreys: Time course of intracellular associations, processing, and cleavages of Ii forms and class II major histocompatibility complex molecules. J Biol Chem 264, 1631-7 (1989)
    • (1989) J Biol Chem , vol.264 , pp. 1631-1637
    • Nguyen, Q.V.1    Humphreys, R.E.2
  • 3
    • 0024565825 scopus 로고
    • Inhibition by leupeptin and antipain of the intracellular proteolysis of Ii
    • Nguyen Q. V., W. Knapp & R. E. Humphreys: Inhibition by leupeptin and antipain of the intracellular proteolysis of Ii. Hum Immunol 24, 153-63 (1989)
    • (1989) Hum Immunol , vol.24 , pp. 153-163
    • Nguyen, Q.V.1    Knapp, W.2    Humphreys, R.E.3
  • 4
    • 0025001806 scopus 로고
    • Identification of p70 and p80 associations with class II MHC molecules and Ii
    • Sorli C. H., P. S. Reisert, W. J. Welch & R. E. Humphreys: Identification of p70 and p80 associations with class II MHC molecules and Ii. Am J Hematol 35, 157-66 (1990)
    • (1990) Am J Hematol , vol.35 , pp. 157-166
    • Sorli, C.H.1    Reisert, P.S.2    Welch, W.J.3    Humphreys, R.E.4
  • 5
    • 0027514421 scopus 로고
    • Effects of brefeldin A on cleavage of invariant chain to p21 and p10 and the appearance of Ii-freed class II MHC dimers
    • Nguyen Q. V., A. M. Roskey & R. E. Humphreys: Effects of brefeldin A on cleavage of invariant chain to p21 and p10 and the appearance of Ii-freed class II MHC dimers. Mol Immunol 30, 137-44 (1993)
    • (1993) Mol Immunol , vol.30 , pp. 137-144
    • Nguyen, Q.V.1    Roskey, A.M.2    Humphreys, R.E.3
  • 6
    • 0027771655 scopus 로고
    • Characterization of the invariant chain C-terminus (Glu183-Glu193) epitope which is obscured in processed Ii, MHC alpha,beta trimers
    • Nguyen Q. V., W. Knapp & R. E. Humphreys: Characterization of the invariant chain C-terminus (Glu183-Glu193) epitope which is obscured in processed Ii, MHC alpha,beta trimers. Mol Immunol 30, 1679-84 (1993)
    • (1993) Mol Immunol , vol.30 , pp. 1679-1684
    • Nguyen, Q.V.1    Knapp, W.2    Humphreys, R.E.3
  • 7
    • 0028945446 scopus 로고
    • Structural analysis of invariant chain subsets as a function of their association with MHC class II chains
    • Nguyen Q. V., V. E. Reyes & R. E. Humphreys: Structural analysis of invariant chain subsets as a function of their association with MHC class II chains. Arch Biochem Biophys 317, 128-32 (1995)
    • (1995) Arch Biochem Biophys , vol.317 , pp. 128-132
    • Nguyen, Q.V.1    Reyes, V.E.2    Humphreys, R.E.3
  • 9
    • 0024439926 scopus 로고
    • Time-dependent cleavage of a high-mannose form of Ii to p25 in an intracellular compartment
    • Thomas L. J., R. E. Humphreys, W. Knapp & Q. V. Nguyen: Time-dependent cleavage of a high-mannose form of Ii to p25 in an intracellular compartment. Am J Hematol 32, 167-77 (1989)
    • (1989) Am J Hematol , vol.32 , pp. 167-177
    • Thomas, L.J.1    Humphreys, R.E.2    Knapp, W.3    Nguyen, Q.V.4
  • 10
    • 0025760601 scopus 로고
    • Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains
    • Reyes V. E., S. Lu & R. E. Humphreys: Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains. J Immunol 146, 3877-80 (1991)
    • (1991) J Immunol , vol.146 , pp. 3877-3880
    • Reyes, V.E.1    Lu, S.2    Humphreys, R.E.3
  • 11
    • 0028219119 scopus 로고
    • More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release
    • Daibata M., M. Xu, R. E. Humphreys & V. E. Reyes: More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release. Mol Immunol 31, 255-60 (1994)
    • (1994) Mol Immunol , vol.31 , pp. 255-260
    • Daibata, M.1    Xu, M.2    Humphreys, R.E.3    Reyes, V.E.4
  • 12
    • 0025294386 scopus 로고
    • Role of recurrent hydrophobic residues in catalysis of helix formation by T cell-presented peptides in the presence of lipid vesicles
    • Lu S., V. E. Reyes, R. A. Lew, J. Anderson, J. Mole, R. E. Humphreys & T. Ciardelli: Role of recurrent hydrophobic residues in catalysis of helix formation by T cell-presented peptides in the presence of lipid vesicles. J Immunol 145, 899-904 (1990)
    • (1990) J Immunol , vol.145 , pp. 899-904
    • Lu, S.1    Reyes, V.E.2    Lew, R.A.3    Anderson, J.4    Mole, J.5    Humphreys, R.E.6    Ciardelli, T.7
  • 13
    • 0029014498 scopus 로고
    • Invariant chain peptides enhancing or inhibiting the presentation of antigenic peptides by major histocompatibility complex class II molecules
    • Adams S. & R. E. Humphreys: Invariant chain peptides enhancing or inhibiting the presentation of antigenic peptides by major histocompatibility complex class II molecules. Eur J Immunol 25, 1693-702 (1995)
    • (1995) Eur J Immunol , vol.25 , pp. 1693-1702
    • Adams, S.1    Humphreys, R.E.2
  • 14
    • 0034212481 scopus 로고    scopus 로고
    • Increasing the potency of MHC class II-presented epitopes by linkage to Ii-Key peptide
    • Humphreys R. E., S. Adams, G. Koldzic, B. Nedelescu, E. von Hofe & M. Xu: Increasing the potency of MHC class II-presented epitopes by linkage to Ii-Key peptide. Vaccine 18, 2693-7 (2000)
    • (2000) Vaccine , vol.18 , pp. 2693-2697
    • Humphreys, R.E.1    Adams, S.2    Koldzic, G.3    Nedelescu, B.4    Von Hofe, E.5    Xu, M.6
  • 15
    • 0028024560 scopus 로고
    • Cathepsin B cleavage and release of invariant chain from MHC class II molecules follow a staged pattern
    • Xu M., G. A. Capraro, M. Daibata, V. E. Reyes & R. E. Humphreys: Cathepsin B cleavage and release of invariant chain from MHC class II molecules follow a staged pattern. Mol Immunol 31, 723-31 (1994)
    • (1994) Mol Immunol , vol.31 , pp. 723-731
    • Xu, M.1    Capraro, G.A.2    Daibata, M.3    Reyes, V.E.4    Humphreys, R.E.5
  • 16
    • 0028048184 scopus 로고
    • Invariant chain dissociation from class II MHC is a catalyst for foreign peptide binding
    • Reyes V. E., M. Daibata, R. Espejo & R. E. Humphreys: Invariant chain dissociation from class II MHC is a catalyst for foreign peptide binding. Ann N Y Acad Sci 730, 338-41 (1994)
    • (1994) Ann N Y Acad Sci , vol.730 , pp. 338-341
    • Reyes, V.E.1    Daibata, M.2    Espejo, R.3    Humphreys, R.E.4
  • 17
    • 0027484480 scopus 로고
    • Favored and suppressed patterns of hydrophobia and nonhydrophobic amino acids in protein sequences
    • Vazquez S., C. Thomas, R. A. Lew & R. E. Humphreys: Favored and suppressed patterns of hydrophobia and nonhydrophobic amino acids in protein sequences. Proc Natl Acad Sci U S A 90, 9100-4 (1993)
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9100-9104
    • Vazquez, S.1    Thomas, C.2    Lew, R.A.3    Humphreys, R.E.4
  • 18
    • 0025779077 scopus 로고
    • Number and placement of hydrophobic residues in a longitudinal strip governs helix formation of peptides in the presence of lipid vesicles
    • Lu S., T. Ciardelli, V. E. Reyes & R. E. Humphreys: Number and placement of hydrophobic residues in a longitudinal strip governs helix formation of peptides in the presence of lipid vesicles. J Biol Chem 266, 10054-7 (1991)
    • (1991) J Biol Chem , vol.266 , pp. 10054-10057
    • Lu, S.1    Ciardelli, T.2    Reyes, V.E.3    Humphreys, R.E.4
  • 19
    • 0028348369 scopus 로고
    • Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
    • Stern L. J., J. H. Brown, T. S. Jardetzky, J. C. Gorga, R. G. Urban, J. L. Strominger & D. C. Wiley: Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-21 (1994)
    • (1994) Nature , vol.368 , pp. 215-221
    • Stern, L.J.1    Brown, J.H.2    Jardetzky, T.S.3    Gorga, J.C.4    Urban, R.G.5    Strominger, J.L.6    Wiley, D.C.7
  • 20
    • 0030773347 scopus 로고    scopus 로고
    • Biological activity and therapeutic potential of homologs of an Ii peptide which regulates antigenic peptide binding to cell surface MHC class II molecules
    • Adams S., F. Albericio, J. Alsina, E. R. Smith & R. E. Humphreys: Biological activity and therapeutic potential of homologs of an Ii peptide which regulates antigenic peptide binding to cell surface MHC class II molecules. Arzneimittelforschung 47, 1069-77 (1997)
    • (1997) Arzneimittelforschung , vol.47 , pp. 1069-1077
    • Adams, S.1    Albericio, F.2    Alsina, J.3    Smith, E.R.4    Humphreys, R.E.5
  • 21
    • 0028823585 scopus 로고
    • The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
    • Ghosh P., M. Amaya, E. Mellins & D. C. Wiley: The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378, 457-62 (1995)
    • (1995) Nature , vol.378 , pp. 457-462
    • Ghosh, P.1    Amaya, M.2    Mellins, E.3    Wiley, D.C.4
  • 25
    • 0034950193 scopus 로고    scopus 로고
    • MHC class II allosteric site drugs: New immunotherapeutics for malignant, infectious and autoimmune diseases
    • Xu, M., J. Li, J. V. Gulfo, E. Von Hofe & R. E. Humphreys: MHC class II allosteric site drugs: new immunotherapeutics for malignant, infectious and autoimmune diseases. Scand J Immunol 54, 39-44 (2001)
    • (2001) Scand J Immunol , vol.54 , pp. 39-44
    • Xu, M.1    Li, J.2    Gulfo, J.V.3    Von Hofe, E.4    Humphreys, R.E.5
  • 26
    • 0028880008 scopus 로고
    • Self-release of CLIP in peptide loading of HLA-DR molecules
    • Kropshofer H., A. B. Vogt, L. J. Stern & G. J. Hammerling: Self-release of CLIP in peptide loading of HLA-DR molecules. Science 270, 1357-9 (1995)
    • (1995) Science , vol.270 , pp. 1357-1359
    • Kropshofer, H.1    Vogt, A.B.2    Stern, L.J.3    Hammerling, G.J.4
  • 28
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larch, M. & D. C. Wraith: Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 11, S69-76 (2005)
    • (2005) Nat Med , vol.11
    • Larch, M.1    Wraith, D.C.2
  • 30
    • 0035887163 scopus 로고    scopus 로고
    • Identification of helper T-cell epitopes that encompass or lie proximal to cytotoxic T-cell epitopes in the gp100 melanoma tumor antigen
    • Kobayashi H., J. Lu & E. Celis: Identification of helper T-cell epitopes that encompass or lie proximal to cytotoxic T-cell epitopes in the gp100 melanoma tumor antigen. Cancer Res 61, 7577-84 (2001)
    • (2001) Cancer Res , vol.61 , pp. 7577-7584
    • Kobayashi, H.1    Lu, J.2    Celis, E.3
  • 31
    • 0034667948 scopus 로고    scopus 로고
    • In vitro and in vivo induction of a Th cell response toward peptides of the melanoma-associated glycoprotein 100 protein selected by the TEPITOPE program
    • Cochlovius B., M. Stassar, O. Christ, L. Raddrizzani, J. Hammer, I. Mytilineos & M. Zoller: In vitro and in vivo induction of a Th cell response toward peptides of the melanoma-associated glycoprotein 100 protein selected by the TEPITOPE program. J Immunol 165, 4731-41 (2000)
    • (2000) J Immunol , vol.165 , pp. 4731-4741
    • Cochlovius, B.1    Stassar, M.2    Christ, O.3    Raddrizzani, L.4    Hammer, J.5    Mytilineos, I.6    Zoller, M.7
  • 36
    • 0036740190 scopus 로고    scopus 로고
    • Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor
    • Sant'Angelo D. B., E. Robinson, C. A. Janeway, Jr. & L. K. Denzin: Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor. Eur J Immunol 32, 2510-20 (2002)
    • (2002) Eur J Immunol , vol.32 , pp. 2510-2520
    • Sant'Angelo, D.B.1    Robinson, E.2    Janeway Jr., C.A.3    Denzin, L.K.4
  • 38
    • 0036605567 scopus 로고    scopus 로고
    • Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines
    • Disis M. L., T. A. Gooley, K. Rinn, D. Davis, M. Piepkorn, M. A. Cheever, K. L. Knutson & K. Schiffman: Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J Clin Oncol 20, 2624-32 (2002)
    • (2002) J Clin Oncol , vol.20 , pp. 2624-2632
    • Disis, M.L.1    Gooley, T.A.2    Rinn, K.3    Davis, D.4    Piepkorn, M.5    Cheever, M.A.6    Knutson, K.L.7    Schiffman, K.8
  • 40
    • 0036945807 scopus 로고    scopus 로고
    • Getting peptide vaccines to work: Just a matter of quality control?
    • Celis E.: Getting peptide vaccines to work: just a matter of quality control? J Clin Invest 110, 1765-8 (2002)
    • (2002) J Clin Invest , vol.110 , pp. 1765-1768
    • Celis, E.1
  • 41
    • 0031782910 scopus 로고    scopus 로고
    • The role of CD4+ T cell responses in antitumor immunity
    • Pardoll D. M. & S. L. Topalian: The role of CD4+ T cell responses in antitumor immunity. Curr Opin Immunol 10, 588-94 (1998)
    • (1998) Curr Opin Immunol , vol.10 , pp. 588-594
    • Pardoll, D.M.1    Topalian, S.L.2
  • 42
    • 0035322914 scopus 로고    scopus 로고
    • Vaccines for melanoma: Translating basic immunology into new therapies
    • Wolchok J. D. & P. O. Livingston: Vaccines for melanoma: translating basic immunology into new therapies. Lancet Oncol 2, 205-11 (2001)
    • (2001) Lancet Oncol , vol.2 , pp. 205-211
    • Wolchok, J.D.1    Livingston, P.O.2
  • 43
    • 32844465107 scopus 로고    scopus 로고
    • Ligand epitope antigen presentation system vaccines against herpes simplex virus
    • Goel N., D. H. Zimmerman & K. S. Rosenthal: Ligand epitope antigen presentation system vaccines against herpes simplex virus. Front Biosci 10, 966-74 (2005)
    • (2005) Front Biosci , vol.10 , pp. 966-974
    • Goel, N.1    Zimmerman, D.H.2    Rosenthal, K.S.3
  • 44
    • 0037288790 scopus 로고    scopus 로고
    • Role of CD4+ T lymphocytes in antitumor immunity
    • Rajnavolgyi E. & A. Lanyi: Role of CD4+ T lymphocytes in antitumor immunity. Adv Cancer Res 87, 195-249 (2003)
    • (2003) Adv Cancer Res , vol.87 , pp. 195-249
    • Rajnavolgyi, E.1    Lanyi, A.2
  • 47
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge J. P., F. Di Rosa & P. Matzinger: A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474-8 (1998)
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    Di Rosa, F.2    Matzinger, P.3
  • 48
    • 0033103127 scopus 로고    scopus 로고
    • CD4 T cells and their role in antitumor immune responses
    • Toes R. E., F. Ossendorp, R. Offringa & C. J. Melief: CD4 T cells and their role in antitumor immune responses. J Exp Med 189, 753-6 (1999)
    • (1999) J Exp Med , vol.189 , pp. 753-756
    • Toes, R.E.1    Ossendorp, F.2    Offringa, R.3    Melief, C.J.4
  • 50
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg S. A., J. C. Yang & N. P. Restifo: Cancer immunotherapy: moving beyond current vaccines. Nat Med 10, 909-15 (2004)
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 52
    • 0029053749 scopus 로고
    • Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines
    • Fisk B., T. L. Blevins, J. T. Wharton & C. G. Ioannides: Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines. J Exp Med 181, 2109-17 (1995)
    • (1995) J Exp Med , vol.181 , pp. 2109-2117
    • Fisk, B.1    Blevins, T.L.2    Wharton, J.T.3    Ioannides, C.G.4
  • 55
    • 0032520044 scopus 로고    scopus 로고
    • Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are recognized by in vitro induced specific cytotoxic T lymphocytes
    • Brossart P., G. Stuhler, T. Flad, S. Stevanovic, H. G. Rammensee, L. Kanz & W. Brugger: Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are recognized by in vitro induced specific cytotoxic T lymphocytes. Cancer Res 58, 732-6 (1998)
    • (1998) Cancer Res , vol.58 , pp. 732-736
    • Brossart, P.1    Stuhler, G.2    Flad, T.3    Stevanovic, S.4    Rammensee, H.G.5    Kanz, L.6    Brugger, W.7
  • 56
    • 0034255737 scopus 로고    scopus 로고
    • HER-2/neu is expressed in human renal cell carcinoma at heterogeneous levels independently of tumor grading and staging and can be recognized by HLA-A2.1-restricted cytotoxic T lymphocytes
    • Seliger B., Y. Rongcun, D. Atkins, S. Hammers, C. Huber, S. Storkel & R. Kiessling: HER-2/neu is expressed in human renal cell carcinoma at heterogeneous levels independently of tumor grading and staging and can be recognized by HLA-A2.1-restricted cytotoxic T lymphocytes. Int J Cancer 87, 349-59 (2000)
    • (2000) Int J Cancer , vol.87 , pp. 349-359
    • Seliger, B.1    Rongcun, Y.2    Atkins, D.3    Hammers, S.4    Huber, C.5    Storkel, S.6    Kiessling, R.7
  • 57
    • 0032213456 scopus 로고    scopus 로고
    • Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors
    • Zaks T. Z. & S. A. Rosenberg: Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors. Cancer Res 58, 4902-8 (1998)
    • (1998) Cancer Res , vol.58 , pp. 4902-4908
    • Zaks, T.Z.1    Rosenberg, S.A.2
  • 58
    • 0034471993 scopus 로고    scopus 로고
    • Clinical trials of HER-2/neu-specific vaccines
    • discussion 92-100
    • Murray J. L., D. Przepiorka & C. G. Ioannides: Clinical trials of HER-2/neu-specific vaccines. Semin Oncol 27, 71-5; discussion 92-100 (2000)
    • (2000) Semin Oncol , vol.27 , pp. 71-75
    • Murray, J.L.1    Przepiorka, D.2    Ioannides, C.G.3
  • 59
    • 0036098003 scopus 로고    scopus 로고
    • Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity
    • Knutson K. L., K. Schiffman, M. A. Cheever & M. L. Disis: Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity. Clin Cancer Res 8, 1014-8 (2002)
    • (2002) Clin Cancer Res , vol.8 , pp. 1014-1018
    • Knutson, K.L.1    Schiffman, K.2    Cheever, M.A.3    Disis, M.L.4
  • 60
    • 0036847689 scopus 로고    scopus 로고
    • Toxicity, immunogenicity, and induction of E75-specific tumor-lytic CTLs by HER-2 peptide E75 (369-377) combined with granulocyte macrophage colony-stimulating factor in HLA-A2+ patients with metastatic breast and ovarian cancer
    • Murray J. L., M. E. Gillogly, D. Przepiorka, H. Brewer, N. K. Ibrahim, D. J. Booser, G. N. Hortobagyi, A. P. Kudelka, K. H. Grabstein, M. A. Cheever & C. G. Ioannides: Toxicity, immunogenicity, and induction of E75-specific tumor-lytic CTLs by HER-2 peptide E75 (369-377) combined with granulocyte macrophage colony-stimulating factor in HLA-A2+ patients with metastatic breast and ovarian cancer. Clin Cancer Res 8, 3407-18 (2002)
    • (2002) Clin Cancer Res , vol.8 , pp. 3407-3418
    • Murray, J.L.1    Gillogly, M.E.2    Przepiorka, D.3    Brewer, H.4    Ibrahim, N.K.5    Booser, D.J.6    Hortobagyi, G.N.7    Kudelka, A.P.8    Grabstein, K.H.9    Cheever, M.A.10    Ioannides, C.G.11
  • 62
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • Brossart P., S. Wirths, G. Stuhler, V. L. Reichardt, L. Kanz & W. Brugger: Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 96, 3102-8 (2000)
    • (2000) Blood , vol.96 , pp. 3102-3108
    • Brossart, P.1    Wirths, S.2    Stuhler, G.3    Reichardt, V.L.4    Kanz, L.5    Brugger, W.6
  • 64
    • 0030802482 scopus 로고    scopus 로고
    • Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3
    • Halder T., G. Pawelec, A. F. Kirkin, J. Zeuthen, H. E. Meyer, L. Kun & H. Kalbacher: Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3. Cancer Res 57, 3238-44 (1997)
    • (1997) Cancer Res , vol.57 , pp. 3238-3244
    • Halder, T.1    Pawelec, G.2    Kirkin, A.F.3    Zeuthen, J.4    Meyer, H.E.5    Kun, L.6    Kalbacher, H.7
  • 65
    • 0035113705 scopus 로고    scopus 로고
    • Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients
    • Knutson K. L., K. Schiffman & M. L. Disis: Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J Clin Invest 107, 477-84 (2001)
    • (2001) J Clin Invest , vol.107 , pp. 477-484
    • Knutson, K.L.1    Schiffman, K.2    Disis, M.L.3
  • 66
    • 0742304315 scopus 로고    scopus 로고
    • Peptide vaccine trials for melanoma: Preclinical background and clinical results
    • Talebi T. & J. S. Weber: Peptide vaccine trials for melanoma: preclinical background and clinical results. Semin Cancer Biol 13, 431-8 (2003)
    • (2003) Semin Cancer Biol , vol.13 , pp. 431-438
    • Talebi, T.1    Weber, J.S.2
  • 68
    • 0036644333 scopus 로고    scopus 로고
    • Antimelanoma activity of CTL generated from peripheral blood mononuclear cells after stimulation with autologous dendritic cells pulsed with melanoma gp100 peptide G209-2M is correlated to TCR avidity
    • Yang S., G. P. Linette, S. Longerich & F. G. Haluska: Antimelanoma activity of CTL generated from peripheral blood mononuclear cells after stimulation with autologous dendritic cells pulsed with melanoma gp100 peptide G209-2M is correlated to TCR avidity. J Immunol 169, 531-9 (2002)
    • (2002) J Immunol , vol.169 , pp. 531-539
    • Yang, S.1    Linette, G.P.2    Longerich, S.3    Haluska, F.G.4
  • 69
    • 0037883616 scopus 로고    scopus 로고
    • Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules
    • Parkhurst M. R., C. DePan, J. P. Riley, S. A. Rosenberg & S. Shu: Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules. J Immunol 170, 5317-25 (2003)
    • (2003) J Immunol , vol.170 , pp. 5317-5325
    • Parkhurst, M.R.1    DePan, C.2    Riley, J.P.3    Rosenberg, S.A.4    Shu, S.5
  • 70
    • 2942644555 scopus 로고    scopus 로고
    • Expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma vaccinated with CD34+ progenitor-derived dendritic cells
    • Paczesny S., J. Banchereau, K. M. Wittkowski, G. Saracino, J. Fay & A. K. Palucka: Expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma vaccinated with CD34+ progenitor-derived dendritic cells. J Exp Med 199, 1503-11 (2004)
    • (2004) J Exp Med , vol.199 , pp. 1503-1511
    • Paczesny, S.1    Banchereau, J.2    Wittkowski, K.M.3    Saracino, G.4    Fay, J.5    Palucka, A.K.6
  • 71
    • 2442680269 scopus 로고    scopus 로고
    • Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes
    • Liao X., Y. Li, C. Bonini, S. Nair, E. Gilboa, P. D. Greenberg & C. Yee: Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. Mol Ther 9, 757-64 (2004)
    • (2004) Mol Ther , vol.9 , pp. 757-764
    • Liao, X.1    Li, Y.2    Bonini, C.3    Nair, S.4    Gilboa, E.5    Greenberg, P.D.6    Yee, C.7
  • 72
    • 0034910314 scopus 로고    scopus 로고
    • Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor
    • Rakhmilevich A. L., M. Imboden, Z. Hao, M. D. Macklin, T. Roberts, K. M. Wright, M. R. Albertini, N. S. Yang & P. M. Sondel: Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor. Clin Cancer Res 7, 952-61 (2001)
    • (2001) Clin Cancer Res , vol.7 , pp. 952-961
    • Rakhmilevich, A.L.1    Imboden, M.2    Hao, Z.3    Macklin, M.D.4    Roberts, T.5    Wright, K.M.6    Albertini, M.R.7    Yang, N.S.8    Sondel, P.M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.