Her-2/neu-derived peptides are tumor-associated antigens expressed by human renal cell and colon carcinoma lines and are recognized by in vitro induced specific cytotoxic T lymphocytes

Cancer Research

Volumn 58, Issue 4, 1998, Pages 732-736

  Brossant, Peter ^a   Stuhler, Gernot ^a   Flad, Thomas ^a   Stevanovic, Stefan ^a   Rammensee, Hans Georg ^a   Kanz, Lothar ^a   Brugger, Wolfram ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ALLELE; ANTIGEN EXPRESSION; ARTICLE; COLON CARCINOMA; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KIDNEY CARCINOMA; MOLECULAR RECOGNITION; ONCOGENE NEU; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; TARGET CELL; TISSUE SPECIFICITY;

EID: 0032520044     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Germain, R. N., and Margulies, D. H. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol, 11: 403-450, 1993.
2. Bevan, M. J. Antigen presentation to cytotoxic T lymphocytes in vivo. J. Exp. Med., 182: 639-641, 1995.
3. Rammensee, H. G., Falk, K., and Rötzschke, O. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol., 11: 213-244, 1993.
4. Robbins, P. F., and Kawakami, Y. Human tumor antigens recognized by T cells. Curr. Opin. Immunol., 8: 628-636, 1996.
5. Yamamoto, T., Ikawa, S., Akiyama, T., Semba, K., Nomura, N., Miyajima, N., Saito, T., and Toyoshima, K. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature (Lond.), 319: 230-234, 1986.
6. Hazan, R., Margolis, B., Dombalagian, M., Ullrich, A., Zilberstein, A., and Schlessinger, J. Identification of autophosphorylation sites of HER-2/neu. Cell Growth Differ., 1: 3-7, 1990.
7. Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J., Ullrich, A., and Press, M. F. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science (Washington DC), 244: 707-712, 1989.
8. Pauletti, G., Godolphin, W., Press, M. F., and Slamon, D. J. Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization. Oncogene, 13: 63-72, 1996.
9. Peoples, G. E., Goedegebuure, P. S., Smith, R., Linehan, D. C., Yoshino, I., and Eberlein, T. J. Breast and ovarian cancer specific cytotoxic T lymphocytes recognize the same HER-2/neu-derived peptide. Proc. Natl. Acad. Sci. USA, 92: 432-436, 1995.
10. Fisk, B., Blevins, T. L., Wharton, J. T., and Ioannides, C. G. Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumorspecific cytotoxic T lymphocyte lines. J. Exp. Med., 181: 2109-2717, 1995.
11. Pieper, M., Goedegebuure, P. S., Linehan, D. C. Ganguly, E., Douville, C. C., and Eberlein, T. The Her2/neu-derived peptide p654-662 is a tumor-associated antigen in human pancreatic cancer recognized by cytotoxic T lymphocytes. Eur. J. Immunol., 27: 1115-1123, 1997.
12. Linehan, D. C., Goedegebuure, P. S., Peoples, G. E., Rogers, S. O., and Eberlein, T. J. Tumor-specific and HLA-A2 restricted cytolysis by tumor-associated lymphocytes in human metastatic breast cancer. J. Immunol., 155: 4486-4491, 1995.
13. Peoples, G. E., Smith, R. C., Linehan, D. C., Yoshino, I., Goedegebuure, P. S., and Eberlein, T. J. Shared T-cell epitopes in epithelial tumors. Cell. Immunol., 164: 279-286, 1995.
14. Brossart, P., and Bevan, M. J. Selective activation of Fas/FasL mediated cytotoxicity by a self-peptide. J. Exp. Med., 183: 2449-2458, 1996.
15. Houbiers, J. G., Nijman, H. W., van der Burg, S. H., van der Burg, S. H., Drijfhout, J. W., Kenemans, P., van de Velde, C. J., Brand, A., Momburg, F., Kast, W. M., and Melief, C. J. In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild type p53. Eur. J. Immunol., 23: 2072-2077, 1993.
16. Janeway, C. A., and Bottomly, K. Signals and signs for lymphocytes responses. Cell, 76: 275-285, 1994.
17. Steinman, A. M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol., 9: 271-296, 1991.
18. Steinman, R. M., Witmer-Pack, M., and Inaba, K. Dendritic cells: antigen presentation, accessory function and clinical relevance. Adv. Exp. Med. Biol., 329: 1-9, 1993.
19. Cella, M., Sallusto, F., and Lanzavecchia, A. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol., 9: 10-16, 1997.
20. Porgador, A., and Gilboa, E. Bone-marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes. J. Exp. Med., 182: 255-260, 1995.
21. Celluzzi, C. M., Mayordomo, J. I., Storkus, W. J., Lotze, M. T., and Falo, L. D. Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. J. Exp. Med., 183: 283-287, 1996.
22. Zitvogel, L., Mayordomo, J. I., Tjandrawan, T., DeLeo, A. B., Clarke, M. R., Lotze, M. T., and Storkus, W. J. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med., 183; 87-97, 1996.
23. Paglia, P., Chiodoni, C., Rodolfo, M., and Colombo, M. P. Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J. Exp. Med., 183: 317-322, 1996.
24. Brossart, P., Goldrath A. W., Butz E. A., Martin, S., and Bevan, M. J. Virus mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL. J. Immunol., 158: 3270-3276, 1997.
25. Brossart, P., and Bevan, M. J. Presentation of exogenous antigens on MHC class I molecules by dendritic cells: pathway of presentation and regulation by cytokines. Blood, 90: 1594-1599, 1997.
26. Sallusto, F., and Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony stimulating factor plus interleukin 4 and down regulated by tumour necrosis factor α. J. Exp. Med., 179: 1109-1118, 1994.
27. Zhou, L. J., and Tedder, T. F. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc. Natl. Acad. Sci. USA, 93: 2588-2592, 1996.
28. Chapuis, F., Rosenzwajg, M., Yagello, M., Ekman, M., Biberfeld, P., and Gluckman, J. C. Differentiation of human dendritic cells from monocytes in vitro. Eur. J. Immunol., 27: 431-441, 1997.
29. Romani, N., Reider, D., Heuer, M., Ebner, S., Kampgen, E., Eibl, B., Niederwieser, D., and Schuler, G. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J. Immunol. Methods, 196: 137-151, 1996.
30. Topalian, S. L., Gonzales, M. I., Parkhurst, M., Li, Y. F., Southwood, S., Sette, A., Rosenberg, S. A., and Robbins, P. F. Melanoma-specific CD4+ T cells recognize non-mutated HLA-DR-restricted tyrosinase epitopes. J. Exp. Med., 183: 1965-1971, 1996.
31. Bernhard, H., Jager, E., Maeurer, M. J., Meyer-zum-Buschenfelde, K. H., and Knuth, A. Tumor associated antigens in human renal cell carcinoma: MHC restricted recognition by cytotoxic T lymphocytes. Tissue Antigens, 48: 22-31, 1996.
32. Bernhard, H., Maeurer, M. J., Jager, E., Wolfel, T., Schneider, J., Karbach, J., Seliger, B., Huber, C., Storkus, W. S., Lotze, M. T., Meyer-zum-Buschenfelde, K. H., and Knuth, A. Recognition of human renal cell carcinoma and melanoma by HLA-A2 restricted cytotoxic T lymphocytes is mediated by shared peptide epitopes and upregulated by interferon-gamma. Scand. J. Immunol., 44: 285-292, 1996.
33. Brouwenstijn, N., Gaugler, B., Kruse, K. M., van der Spek, C. W., Mulder, A., Osanto, S., van den Eynde, B. J., and Schrier, P. I. Renal cell carcinoma specific lysis by cytotoxic T-lymphocytes clones isolated from peripheral blood lymphocytes and tumor-infiltrating lymphocytes. Int. J. Cancer, 68: 177-182, 1996.
34. Gaugler, B., Brouwenstijn, N., Vantomme, V., Szikora, J. P., van der Spek, C. W., Patard, J. J., Boon, T., Schrier, P., and Van den Eyende, B. J. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. Immunogenetics, 44: 323-330, 1996.
35. Stumm, G., Eberwein, S., Rostock-Wolf, S., Stein, H., Pomer, S., Schlegel, J., and Waldherr, R. Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis. Int. J. Cancer, 69: 17-22, 1996.
36. Fisch, P., Köhler, G., Garbe, A., Herbst, B., Wider, D., Kohler, H., Schaefer, H. E., Mertelsmann, R., Brugger, W., and Kanz, L. Generation of antigen-presenting cells for soluble protein antigens ex vivo from peripheral blood CD34+ hematopoetic progenitor cells in cancer patients. Eur. J. Immunol., 26: 595-600, 1996.
37. Bernhard, H., Disis, M. L., Heimfeld, S., Hand, S., Gralow, J. R., and Cheever, M. A. Generation of immunostimulatory dendritic cells from human CD34+ hematopoetic progenitor cells of the bone marrow and peripheral blood. Cancer Res., 55: 1099-1104, 1995.