Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts

Journal of Gene Medicine

Volumn 8, Issue 2, 2006, Pages 242-248

  Tavakoli, Reza ^b   Gazdhar, Amiq ^a   Pierog, Jaroslaw ^a   Bogdanova, Anna ^d   Gugger, Mathias ^e   Pringle, Ian A ^c   Gill, Deborah R ^c   Hyde, Stephen C ^c   Genoni, Michele ^b   Schmid, Ralph A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b TRIEMLI HOSPITAL   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

Heart transplantation; In vivo electroporation; Non viral vectors

Indexed keywords

COMPLEMENTARY DNA; INTERLEUKIN 10; MYELOPEROXIDASE;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; ELECTROPORATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNCTIONAL ASSESSMENT; GENE OVEREXPRESSION; GENE TRANSFER; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART BEAT; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; HISTOPATHOLOGY; MALE; NONHUMAN; PALPATION; PRIORITY JOURNAL; RAT; RAT STRAIN; SKELETAL MUSCLE; TIBIALIS ANTERIOR MUSCLE; TISSUE LEVEL;

ANIMALS; ELECTROPORATION; GENE THERAPY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; INTERLEUKIN-10; MALE; MUSCLE, SKELETAL; RATS; RATS, INBRED BN; RATS, INBRED F344; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 32844466610     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.859     Document Type: Article

References (36)

1. Pleyer U, Ritter T, Volk H-D. Immune tolerance and gene therapy in transplantation. Immunology Today 2000; 21: 12-14.
2. Guillot C, Le Mauff B, Cuturi MC, Anegon I. Gene therapy in transplantation in the year 2000: moving towards clinical applications? Gene Ther 2000; 7: 14-19.
3. Salgar SK, Yang D, Ruiz P, Miller J, Tzakis AG. Viral interleukin-10 gene therapy to induce tolerance to solid organ transplants in mice. Transplant Proc 2004; 36: 397-398.
4. Hong YS, Laks H, Cui G, Chong T, Sen L. Localized immunosuppression in the cardiac allograft induced by a new liposome-mediated IL-10 gene therapy. J Heart Lung Transplant 2002; 21: 1188-1200.
5. Mathiesen I. Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther 1999; 6: 508-514.
6. Mir LM, Bureau MF, Rangara R, Schwartz B, Scherman D. Long-term, high-level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle. C R Acad Sci III 1998; 321: 893-899.
7. Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998; 16: 867-870.
8. Neumann ES, Sowers AE, Jordan CA. Electroporation and Electrofusion in Cell Biology, Plenum Press: New York, 1989.
9. Gehl J, Sørensen TH, Nielsen K, et al. In vivo electroporation of skeletal muscle: threshold, efficacy and relation to electric field distribution. Biochim Biophys Acta 1999; 1428: 233-240.
10. Vicat JM, Boisseau S, Jourdes P, et al. Muscle transfection by electroporation with high-voltage and short-pulse currents provides high-level and long-lasting gene expression. Hum Gene Ther 2000; 11: 909-916.
11. Rols MP, Bachaud JM, Giraud P, Chevreau C, Roche H, Teissie J. Electrochemotherapy of cutaneous metastases in malignant melanoma. Melanoma Res 2000; 10: 468-474.
12. Pierog J, Gazdhar A, Stammberger U, et al. Synergistic effect of low dose cyclosporine A and human interleukin 10 overexpression on acute rejection in rat lung allotransplantation. Eur J Cardiothorac Surg 2005; 27: 1030-1035.
13. Matsumoto T, Komori K, Shoji T, et al. Successful and optimized in vivo gene transfer to rabbit carotid artery mediated by electronic pulse. Gene Ther 2001; 8: 1174-1179.
14. Heller R, Jaroszeski M, Atkin A, et al. In vivo gene electroinjection and expression in rat liver. FEBS Lett 1996; 389: 225-228.
15. Blair-Parks K, Weston BC, Dean DA. High-level gene transfer to the cornea using electroporation. J Gene Med 2002; 4: 92-100.
16. Gill DR, Smyth SE, Goddard CA, et al. Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter. Gene Ther 2001; 8: 1539-1546.
17. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225-229.
18. Billingham ME, Cary NR, Hammond ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990; 9: 587-593.
19. Bradley PP, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78: 206-209.
20. Mullane KM, Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 1985; 14: 157-167.
21. Zuckermann A, Reichenspurner H, Birsan T, et al. Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial. J Thorac Cardiovasc Surg 2003; 125: 891-900.
22. Parekh K, Trulock E, Patterson GA. Use of cyclosporine in lung transplantation. Transplant Proc 2004; 36: 318S-322S.
23. Sembeil R, Sanhadji K, Vivier G, Chargui J, Touraine J-L. Prolonged survival of mouse skin allografts after transplantation of fetal liver cells transduced with hIL-10 gene. Transplant Immunol 2004; 13: 1-8.
24. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081-2095.
25. Del Prete G, De Carli M, Almerigogna F, Giudizi M, Biagiotti R, Romagnani S. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150: 353-360.
26. Brauner R, Wu L, Laks H, et al. Intracoronary gene transfer of immunosuppressive cytokines to cardiac allografts: method and efficacy of adenovirus-mediated transduction. J Thorac Cardiovasc Surg 1997; 113: 1059-1066; discussion 1066-1057.
27. Watkins C, Hopkins J, Harkiss G. Reporter gene expression in dendritic cells after gene gun administration of plasmid DNA. Vaccine 2005; 23: 4247-4256.
28. Lin CR, Tai MH, Cheng JT, et al. Electroporation for direct spinal gene transfer in rats. Neurosci Lett 2002; 317: 1-4.
29. Li W, Fu F, Lu L, et al. Differential effects of exogenous interleukin-10 on cardiac allograft survival: inhibition of rejection by recipient pretreatment reflects impaired host accessory cell function. Transplantation 1999; 68: 1402-1409.
30. Qian S, Li W, Li Y, et al. Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice. Transplantation 1996; 62: 1709-1714.
31. Ozasa T, Newton MR, Dallman MJ, Shimizu S, Gray DW, Morris PJ. Cytokine gene expression in pancreatic islet grafts in the rat. Transplantation 1997; 64: 1152-1159.
32. Yang Z, Zingarelli B, Szabo C. Crucial role of endogenous interleukin-10 production in myocardial ischemia/reperfusion injury. Circulation 2000; 101: 1019-1026.
33. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151: 1224-1234.
34. Cassatella MA, Meda L, Bonora S, Ceska M, Constantin G. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. J Exp Med 1993; 178: 2207-2211.
35. Minter RM, Ferry MA, Rectenwald JE, et al. Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy. Proc Natl Acad Sci USA 2001; 98: 277-282.
36. Tollefsen S, Vordermeier M, Olsen I, et al. DNA injection in combination with electroporation: a novel method for vaccination of farmed ruminants. Scand J Immunol 2003; 57: 229-238.