Determination of surface-bound hydroxypropylcellulose (HPC) on drug particles in colloidal dispersions using size exclusion chromatography: A comparison of ELS and RI detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 40, Issue 5, 2006, Pages 1089-1096

  Zhu, Limin ^a   Seburg, Randal A ^a   Tsai, Eric W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Colloidal dispersions; Evaporative light scattering detection (ELSD); Hydroxypropylcellulose (HPC); Refractive index (RI); Size exclusion chromatography (SEC); Surface bound

Indexed keywords

HYDROXYPROPYLCELLULOSE;

ARTICLE; CALCULATION; COLLOID; CORRELATION ANALYSIS; DISPERSION; DRUG DETERMINATION; EVAPORATION; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; INTERMETHOD COMPARISON; LIGHT SCATTERING; NEBULIZER; PRIORITY JOURNAL; REFRACTION INDEX; SUPERNATANT; TEMPERATURE; ULTRACENTRIFUGATION;

ALGORITHMS; CELLULOSE; CHROMATOGRAPHY, GEL; COLLOIDS; EXCIPIENTS; INDICATORS AND REAGENTS; LIGHT; PARTICLE SIZE; REFRACTOMETRY; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPERATURE;

EID: 32644485871     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.09.014     Document Type: Article

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