Glutathione, oxidative stress and aging

Journal of the American Aging Association

Volumn 19, Issue 4, 1996, Pages 129-139

  Sastre, Juan ^a   Pallardó, Federico V ^a   Viña, Jose ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Aging; Glutathione; Mitochondria; Oxidative stress

Indexed keywords

EID: 32644483759     PISSN: 01619152     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02434082     Document Type: Article

References (104)

1. Allen, R.G., Sohal, R.S.: Role of glutathione in the aging and development of insects. In Insect aging. Collatz, K.G. and Sohal, R.S., Eds. Springer Verlag Berlin Heidelberg 1986 pp 168-181.
2. Al-Turk, W., Stohs, S.J., El-Rashidy F.H., Othman, S., Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age J. Pharm. Pharmacol, 39: 13-16, 1987.
3. Ames, B.N., Shigenaga, M., Hagen, T.M.: Oxidants, antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA, 90: 7915-7922, 1993.
4. Barja, G., Pérez-Campo, R., López-Torres, L., Cadenas, S., Rojas, C.: Low mitochondrial free radical production as a longevity determinant in species following or not the rate of living theory Mech. Aging Dev., 1996 (in press).
5. Beal, M F., Hyman, B.T., Koroshetz, W., Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? TINS, 16. 125-131, 1993.
6. Benzi, G., Marzatico, F., Pastoris, O., Villa, R.F.: Relationship between aging, drug treatment and the cerebral enzymatic antioxidant system. Exp. Gerontol., 24: 137-148, 1989.
7. Buja, L.M., Eigenbrodt, M.L., Eigenbrodt, E.H.: Apoptosis and Necrosis. Basic Types and Mechanisms of Cell Death. Arch. Pathol. Lab Med. 117,1208-1214, 1993.
8. Buttke, T.M., Sandstrom, P A : Oxidative stress as a mediator of apoptosis Immunol. Today, 15:7-10, 1994.
9. Cand, F. and Verdetti, J.: Superoxide dismutase, glutathione peroxidase, catalase. and lipid peroxidation in the major organs of the aging rats. Free Radical Biol. Med., 7:59-63, 1989.
10. Calleja, M., Peña, P., Ugalde, C., Ferreiro, C., Marco, R., Garesse, R: Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J. Biol. Chem. 268.18891-18897, 1993.
11. Cannon, J.G., Orencole, S.F., Fielding, R A., Meydani, M., Meydani, S N., Fiatarone, M.A., Blumberg, J.B., Evans, W. J.. Acute phase response in exercise-interaction of age and vitamin-E on neutrophils and muscle enzyme release. Am. J. Physiol., 259:1990.
12. Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Landum, R.W., Cheng, M.S., Wu, J.F. and Floyd, R.A.: Reversal of age- related increase in brain protein oxidation, decrease in enzyme activity and loss in temporal and spatial memory by chronic administration of the spintrapping compound N-tert-butyl-a-phenylnitrone. Proc. Natl. Acad. Sci. USA, 88:3633-3636, 1991.
13. Chance, B., Sies, H., Boveris, A.: Hydroperoxide metabolism in mammalian organs. Physiological Rev., 59: 527- 604, 1979.
14. Corbisier, P., Remacle, J : Involvement of mitochondria in cell degeneration. Eur. J. Cell Biol., 51:173-182, 1990.
15. Coyle, J., Puttfaarcken, P.: Oxidative stress, glutamate and neurodegenerative disorders. Science, 262: 689-694, 1993.
16. Cutler, R.G.: Antioxidants and aging. Am. J. Clin. Nutr, 53: S373-S379, 1991
17. De la Cruz. J., Burón, I., Roncero, I.: Morphological and functional studies during aging at mitochondrial level. Action of drugs. Int. J. Biochem.. 22:729-735, 1990.
18. Deckwerth, T.L., Johnson, E.M.: Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol., 123: 1207-1222, 1993.
19. Devasagayam, T.P : Senescence-associated decrease of NADPH-induced lipid peroxidation in rat liver microsomes. FEBS Lett. 205,246-50, 1986.
20. Devasagayam, TP and Tarachand, U.: Decreased lipid peroxidation in the rat kidney during gestation. Biochem. Biophys. Res. Commun. 145,134-8, 1987.
21. Estrela, J.M., Obrador, E., Navarro, J., Lasso-de-la-Vega, M.C., Pellicer, J.: Elimination of Ehrlich tumors by ATP-induced growth inhibition, glutathione depletion and X-rays. Nature Med. 1,84-88,1995
22. Ferrer, J.V., Gascó, E., Sastre, J., Pallardó, F.V., Asensi, M., Viña, J.: Age-related changes in glutathione synthesis in the eye lens. Biochem. J., 269. 531-534, 1990.
23. Fucci, L., Oliver, C.N., Coon. M J. and Stadtman, E.R.: Inactivation of key metabolic enzymes by mixed- function oxidation reactions: Possible implication in protein turnover and aging. Proc Natl. Acad. Sci. USA, 80:1521-1525, 1983.
24. Furukawa, T., Meydani, S.N., Blumberg, J.B.: Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice. Mech. Aging Dev., 38. 107-117, 1987.
25. Gadaleta, M.N., Petruzzella, V., Renis, M , Fracasso, F., Cantatore, P.: Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine. Eur. J Biochem. 187: 501-506, 1990.
26. Garcia de la Asunción, J., Millán, A., Plá, R., Bruseghini, L., Esteras, A., Pallardó, F.V., Sastre, J., Viña, J.: Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J., 10: 333-338, 1996.
27. Garland, D., Russell, P., Zigler, J S Jr.: The oxidative modification of lens proteins. Basic Life Sci. 49,347-52 1988.
28. Goldschmidt, L.: Seasonal variations in red cell glutathione levels with aging in mental patients and normal controls Proc Soc. Exp. Biol Med., 133: 555-559, 1970.
29. Gordillo, E., Ayala, A., Lobato, M., Bautista, J., Machado, A.: Possible involvement of histidine residues in the loss of enzymatic activity of rat liver malic enzyme during aging. J. Biol Chem., 263, 8053- 8056, 1988.
30. Gotz, M.E., Freyberger, A., Riederer, P.: Oxidative Stress - A Role in the Pathogenesis of Parkinsons Disease J. Neur. Transmission, 29: 241-249, 1990.
31. Gutteridge, J.M.C.: Copper-phenanthroline induced site specific oxygen radical damage to DNA. Detection of loosely bound trace copper in biological fluids. Biochem. J., 218: 983-985, 1984.
32. Gutteridge, J.M C , Westermarck, T., and Halliwell, B.: Oxygen radical damage in biological systems. In. Free Radicals, Aging and Degenerative Diseases, pp: 99-139. eds J.E. Johson Jr., R Walford, D. Harman, J. Miquel. Alan R. Liss, 1986.
33. Halliwell, B., Gutteridge, J M C : Free Radicals in Biology and Medicine. Claredon, Oxford.1989.
34. Hansford, R.G.: Lipid oxidation by heart mitochondria from young adult and senescent rats. Biochem J, 170 : 285-295, 1978.
35. Harman, D.: Aging: a theory based on free radical and radiation chemistry J Gerontol,11: 298- 300, 1956.
36. Harman, D.: The aging process - Major risk factor for disease and death. Proc. Nat. Acad. Sci. USA, 88:5360-5363, 1991.
37. Hazelton, G.A . Lang, C.A.: Glutathione contents of tissues in the aging mouse. Biochem. J;188: 25-30, 1980.
38. Hockenbery, D M., Oltvai, Z.N., Yin, X.M.. Milliman, C.L., Korsmeyer, S.J.: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251, 1993.
39. Ikebe, S., Tanaka, M., Ohno, K., Sato, W., Hattori, K., Kondo, T., Mizuno, Y.. Ozawa, T.: Increase of deleted mitochondrial DNA in the striatum in Parkinsons Disease and senescence. Biochem. Biophys. Res. Commun,170:1044-1048, 1990.
40. Jankovic, B.D.: Neuromodulation. From phenomenology to molecular evidence. Ann. N.Y Acad. Sci. 741,1-38,1994
41. Johns, D.R.: Mitochondrial DNA and disease. New Engl. J. Med; 333:638-644, 1995.
42. Kalra, J., Rajput, A.H., Mantha, S.V., Chaudhary, A.K., Prasad, K : Oxygen free radical producing activity of polymorphonuclear leukocytes in patients with Parkinson's disease. Moll. Cell Biochem. 112, 181-6,1992.
43. Knekt, P., Heliovaara, M., Rissanen, A., Aromaa, A., Aaran, R.-K : Serum antioxidant vitamins and risk of cataract. Br. Med. J. 305: 1392-1394, 1992.
44. Kroemer, G., Petit, P., Zamzami, N., Vaysiere, J.L. and Mignotte, B.: The biochemistry of programmed cell death. FASEB J; 9:1277-1287, 1995.
45. Ku, H., Brunk, U T., Sohal, R.S.: Relationship between mitochondrial superoxide and hydroperoxide production and longevity of mammalian species. Free Radical Biol. Med; 15: 621-627, 1993.
46. Leske, M.C., Chylack, L.T. Jr., Wu, S.Y : The lens opacities case-control study. Risk factors for cataract. Arch. Ophthalmol. 109: 244-251, 1991.
47. Levine, R.L.: Oxidative modification of glutamine synthetase II. Characterization of the ascorbate model system. J. Biol. Chem; 258:11828-11833, 1983.
48. Linnane, A., Marzuki, S., Ozawa, T., Tanaka, M. Mitochondrial DNA mutations as an important contributor to aging and degenerative diseases. Lancet, 642-645. 1989.
49. Lippman, R.D.: Rapid "in vivo" quantification and comparison of hydroperoxides and oxidized collagen in aging mice, rabbits and man. Exp. Gerontol, 20: 1-5,1985.
50. Lippman, R.D.. Free radical-induced lipoperoxidation and aging. In: Handbook of Free Radicals and Antioxidants in Biomedicine Vol. I eds J Miquel, A.T. Quintanilha. and H. Weber, CRC press, Boca Ratón Cal. USA. 1989
51. 2 and basal and, maximum aerobic capacity. Mech. Aging and Dev., 70. 177-99, 1993.
52. Martensson, J., Steinherz, R., Jain, A., Meister, A.: Glutathione ester prevents buthionine sulfoximine- induced cataracts and lens epithelial cell damage Proc. Natl. Acad. Sci USA, 86 8727-8731, 1989.
53. Medvedev, Z : An Attempt at a Rational Classification of Theories of Aging. Biological Reviews of the Cambridge Philosophical Society, 65: 375-398, 1990.
54. Meydani, M., Evans, W.J., Handelman, G., Biddle, L., Fielding, R.A., Meydani, S.N., Burrill, J., Fiatarone, M.A., Blumberg, J.B., Cannon, J.G.: Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. Am. J. Physiol., 33:R992-R998, 1993
55. Miquel, J , Economos, A.C., Fleming, J., Johnson, J.E. Jr.: Mitochondrial role in cell aging. Exp. Gerontol., 15: 579-91, 1980.
56. Miquel, J., Lundgren, P.R., Johnson, J E.: Spectro-photofluorimetric and electron microscopic study of lipofuscin accumulation in the testis of aging mice, J Gerontol., 33: 5-19. 1978.
57. Miquel, J., Fleming, J.E.: Theoretical and experimental support for an "Oxygen radical-mitochondrial injury" hypothesis of cell aging. In: Free Radicals, Aging and Degenerative Diseases Johnson, J.E. Jr., Walford, R , Harman, D., Miquel, J. eds. FF. New York: Alan R. Liss 1986, pp: 51-74.
58. Mizuno, Y , Ohta, K.: Regional distribution of thiobarbituric acid-reactive products, activities of enzymes regulating the metabolism of free radicals and some of the related enzymes. J. Neurochem, 46: 1344-1352, 1986.
59. Monti, D., Troiano, L., Tropea, F., Grassilli, E., Cossarizza, A., Barozzi, D., Pelloni, M.C., Tamassia, M.G., Bellomo, G., Franceschi, C.: Apoptosis - programmed cell death: a role in the aging process? Am. J. Clin. Nutr 55: 1208S-14S, 1992
60. Muskhelishvili, L , Hart, R.W, Turturro, A., James, S.J.: Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am J. Pathol., 147: 20-24, 1995
61. Nohl and Hegner, Do mitochondria produce oxygen radicals in vivo? Eur. J. Biochem. 82,563-7, 1978.
62. Oliver, C.N., Ahn, B.W., Moerman, E.J., Goldstein, S., Stadtman, E.R.: Age-related changes in oxidized proteins. J. Biol. Chem 262, 5488-5491, 1987.
63. Omenn, G.S., Goodman, G.E., Thomquist, M.D., Balmes, J., Cullen, M R., Glass, A.: Effect of a combination of b carotene and vitamin A on lung cancer and cardiovascular disease. N Engl. J. Med. 334, 1150-5, 1996
64. Orr, W.C., Sohal, R.S.: The effects of catalase gene overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Arch. Biochem. Biophys. 297: 35-41, 1992.
65. Orr, W.C., Sohal, R.S.: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophuila melanogaster. Science, 263: 1128-30, 1994.
66. Pallardó, F.V., Mompó, J., Esteve, J.M., Sastre, J., Asensi, M.A., Vin̈a, J.: Glutathione oxidation increases in apoptotic fibroblasts. Role of apoptosis in aging VIII Biennial Meeting. International Society for Free Radical Research.Barcelona 1-5 October 1996.
67. Paradies, G., Ruggiero, P.M.: Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondria. Arch. Biochem. Biophys., 284: 332-337, 1978.
68. Pinto, R.E., Bartley, WA.: Negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates. Biochem. J. 114, 5-9, 1969
69. Pryor, W.: Oxy-radicals and related species: their formation, lifetimes and reactions. Ann. Rev. Physiol. 48: 657-667, 1986.
70. Ratan, R.R., Murphy, T.H., Baraban, J.M.: Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem., 62: 376-379, 1994.
71. Richter, C., Park, J W, Ames, B.: Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci. USA, 85: 6465- 6467, 1988.
72. Ritchie, J.P., Leutzinger, Y., Partharsarathy, S., Malloy, V., Orentreich, N., Zimmerman, J.A.: Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J., 8: 1302-1307, 1994.
73. Rikans, L.E , Moore, D.R.: Effect of aging on aqueousphase antioxidants in tissues of male Fischer rats Biochem. Biophys. Acta, 966: 269-275, 1988
74. Sáez, G., Thornalley, P.J., Hill, H A O., Hems, R., Bannister, JV.: The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes.Biochim. Biophys. Acta,719,24-31 , 1982
75. Santa María, C., Machado, A.: Effects of development and aging on pulmonary NADP-cytochrome c reductase, glutathione peroxidase, glutathione reductase and thioredoxin reductase activities in male and female rats. Mech. Aging Dev., 37: 183-195, 1987.
76. Sastre, J., Pallardó, F.V., Plá, R . Pellín, A , Juan, G., O'Connor, E., Estrela, J.M , Miquel, J., Vin̄a, J.: Aging of the liver: Age-associated mitochondrial damage in intact hepatocytes Hepatology 1996 (In press)
77. Scalettar, B A., Abney, J.R., Hackenbrock, C.R.: Dynamics, structure and function are coupled in the mitochondrial matrix. Proc. Natl. Acad Sci. USA., 88: 8057-8061, 1991.
78. Schwartzman, R A. and Cidlowski, J.A.: Apoptosis: The biochemistry and Molecular Biology of Programmed Cell Death. Endocrine Rev. 14, 133-151. 1993.
79. Sawada, C.M., Carlson, J.C.: Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat. Mech Aging Dev 41:125-137, 1987.
80. Seto, N.O.L., Hayashi, S., Tener, G.M.: Overexpression of Cu-Zn superoxide dismutase in Drosophila does affect life-span. Proc. Natl. Acad. Sci USA, 87: 4270-74. 1990.
81. Sevanian, A., Hochstein, P.: Mechanisms and consequences of lipid peroxidation in biological systems. Ann Rev. Nutr, 5: 365-390, 1985.
82. Shigenaga, M.K., Hagen, T.M., Ames, B.N.: Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci USA, 91: 10771-8, 1994.
83. Sies, H., Bartoli, G.M., Burk, R.F., Waydhas, C.. Glutathione efflux from perfused rat liver after phenobarbital treatment, during drug oxidations, and in selenium deficiency. Eur. J. Biochem., 89: 113-118, 1978.
84. Sies, H.: Biochemistry of oxidative stress Angewandte Chemie, 25: 1058-1071, 1986.
85. Sohal, R.S.: Hydrogen peroxide production by mitochondria may be a biomarker of aging. Mech. Age Dev., 60: 189-198, 1991
86. Sohal, R.S., Arnold, L.A., Sohal, B,H.: Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species Free Rad. Biol. Med., 9: 495-500, 1990.
87. Sohal. R.S , Dubey, A.: Mitochondrial oxidative damage, hydrogen peroxide release, and aging. Free Radical. Biol. Med., 16: 621- 626, 1994.
88. Stadtman, E.R.: Protein oxidation and aging. Science, 257: 1220-1224, 1992.
89. Starke-Reed, P.E., Oliver, C.N.: Protein oxidation and proteolysis during aging and oxidative stress. Arch. Biochem. Biophys., 275: 559-567, 1989.
90. Smith, C D., Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Stadtman, E.R., Floyd, R.A., Markesbery, W.R.: Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl. Acad. Sci. USA, 88: 10540-10543, 1991.
91. 2+-dependent inner membrane permeability transition. Biochem. J., 294. 719-25, 1993.
92. Trounce, I, Byrne, E., Marzuki, S.: Decline in skeletal muscle mitochondrial chain function: possible factor in aging. Lancet, 25 March: 637-639, 1989
93. Tummino, P.J., Gafni, A.: A comparative study of succinate-supported respiration and ATP/ADP translocation in liver mitochondrial from adult and old rats. Mech Age. Dev., 59: 177-188, 1991.
94. Vaux, D.L : Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad. Sci USA 90,786-789,1993.
95. Vina, J. (Editor). Glutathione: Metabolism and Physiological Functions. CRC Press, Boston, 1990
96. Viña, J., Hems, R., Krebs, H.A.: Maintenance of glutathione content in isolated hepatocytes. Biochem. J. 170, 627-630, 1978
97. Vina, J., Sastre, J., Anton, V., Bruseghini, L., Esteras, A., Asensi, M.: Effect of aging on glutathione metabolism. Protection by antioxidants. In Free Radicals and Aging Emerit, I. and Chance, B.eds. Birkhauser Verlag. Basel. Switzerland 1992, pp. 136-144.
98. Vladimirov, Y.A., Archakov, A.I.: Lipid peroxidation in biomembranes (in Russian) Moscow Nauka 1972.
99. Vladimirov, Y.A.: Free radical lipid peroxidation in biomembranes: Mechanism, regulation, and biological consequences. In: Free Radicals, Aging and Degenerative Diseases, eds.: J.E. Johnson Jr., R. Walford, D. Harman, J. Miquel. Alan R. Liss, pp: 141-195, 1986.
100. Wallace, D.C.: Mitochondrial DNA sequence variation in human evolution and disease. Proc. Natl. Acad. Sci. USA, 91: 8739-8746, 1994.
101. Wolman, M.: Oxidation of lipids and membranes I: in vivo formation of peroxidative lipid polymers. J. Supramol. struct. 3, 80-9, 1975.
102. Yen, T.C., Chen, Y.S., King, K.L, Yeh, S H., Wei, Y.H : Liver mitochondrial respiratory functions decline with age. Biochem. Biophys. Res. Commun., 165: 994-1003, 1989.
103. Zamzami, N , Marchetti, P., Castedo, M., Hirsch, T., Susin, S.A., Masse, B., Kroemer, G.: Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis FEBS lett. 384: 53-57, 1996a.
104. Zamzami, N.P., Susin, S.A., Marchetti, P., Hirsch, T., Castedo, M., Kroemer, G.: Mitochondrial control of nuclear apoptosis. J. Exp. Med., 183: 1533-1544, 1996b.