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Volumn , Issue , 2005, Pages 207-218

Hydroxyacids

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[No Author keywords available]

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EID: 32644459876     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/NOE0824759438-15     Document Type: Chapter
Times cited : (9)

References (72)
  • 1
    • 0032085857 scopus 로고    scopus 로고
    • A plea for active dermocosmetology free of unnecessary animal experimentation
    • Piérard GE, Piérard-Franchimont C. A plea for active dermocosmetology free of unnecessary animal experimentation. Rev Med Liège 1998; 53:350–352.
    • (1998) Rev Med Liège , vol.53 , pp. 350-352
    • Piérard, G.E.1    Piérard-Franchimont, C.2
  • 2
    • 0036278086 scopus 로고    scopus 로고
    • The acidic milieu of the horny layer. New find­ings on the physiology and pathophysiology of skin pH
    • Rippke F, Schreiner V, Schwanitz HJ. The acidic milieu of the horny layer. New find­ings on the physiology and pathophysiology of skin pH. Am J Clin Dermatol 2002; 3:261–272.
    • (2002) Am J Clin Dermatol , vol.3 , pp. 261-272
    • Rippke, F.1    Schreiner, V.2    Schwanitz, H.J.3
  • 3
    • 0037247619 scopus 로고    scopus 로고
    • EEMCO guidance for the in vivoassessment of skin surface pH
    • Parra JL, Paye M, the EEMCO Group. EEMCO guidance for the in vivo assessment of skin surface pH. Skin Pharmacol Appl Skin Physiol 2003; 16:188–202.
    • (2003) Skin Pharmacol Appl Skin Physiol , vol.16 , pp. 188-202
    • Parra, J.L.1    Paye, M.2
  • 4
    • 0034158174 scopus 로고    scopus 로고
    • α-Hydroxy acid-based cosmetic procedures. Guidelines for patient management
    • Tung RC, Bergfeld WF, Vidinos AT, Renzi BK. α-Hydroxy acid-based cosmetic procedures. Guidelines for patient management. Am J Clin Dermatol 2000; 1:81–88.
    • (2000) Am J Clin Dermatol , vol.1 , pp. 81-88
    • Tung, R.C.1    Bergfeld, W.F.2    Vidinos, A.T.3    Renzi, B.K.4
  • 5
    • 0029989481 scopus 로고    scopus 로고
    • Photoprotective and anti-inflammatory effects of topical glycolic acid
    • Perricone NV, Dinardo JC. Photoprotective and anti-inflammatory effects of topical glycolic acid. Dermatol Surg 1996; 22:435–437.
    • (1996) Dermatol Surg , vol.22 , pp. 435-437
    • Perricone, N.V.1    Dinardo, J.C.2
  • 6
    • 0025316397 scopus 로고
    • corneosomes and desquamation. An ultrastruc­tural study
    • Chapman SJ, Walsh A. Desmosomes, corneosomes and desquamation. An ultrastruc­tural study. Arch Dermatol Res 1990; 282:304–310.
    • (1990) Arch Dermatol Res , vol.282 , pp. 304-310
    • Chapman, S.J.1    Desmosomes, W.A.2
  • 7
    • 0024357013 scopus 로고
    • What do you mean by dry skin?
    • Piérard GE. What do you mean by dry skin? Dermatologica 1989; 179:1–2.
    • (1989) Dermatologica , vol.179 , pp. 1-2
    • Piérard, G.E.1
  • 10
    • 0017580502 scopus 로고
    • “Keratolytic” effect of salicylic acid
    • Huber C, Christophers E. “Keratolytic” effect of salicylic acid. Arch Dermatol Res 1977; 257:293–298.
    • (1977) Arch Dermatol Res , vol.257 , pp. 293-298
    • Huber, C.1    Christophers, E.2
  • 11
    • 0018969062 scopus 로고
    • Detection of the action of salicylic acid on the normal stratum corneum
    • Roberts DL, Marshall R, Marks R. Detection of the action of salicylic acid on the normal stratum corneum. Br J Dermatol 1980; 103:191–196.
    • (1980) Br J Dermatol , vol.103 , pp. 191-196
    • Roberts, D.L.1    Marshall, R.2    Marks, R.3
  • 14
    • 0035034829 scopus 로고    scopus 로고
    • Skin surface patterns of xerotic legs: The flexural and accretive types
    • Piérard-Franchimont C, Petit L, Piérard GE. Skin surface patterns of xerotic legs: the flexural and accretive types. Int J Cosmet Sci 2001; 23:121–126.
    • (2001) Int J Cosmet Sci , vol.23 , pp. 121-126
    • Piérard-Franchimont, C.1    Petit, L.2    Piérard, G.E.3
  • 19
    • 0030837681 scopus 로고    scopus 로고
    • Mode of action of glycolic acid on human stratum corneum: Ultrastructural and functional evaluation of the epidermal barrier
    • Fartasch M, Teal J, Menon GK. Mode of action of glycolic acid on human stratum corneum: ultrastructural and functional evaluation of the epidermal barrier. Arch Dermatol Res 1997; 289:404–409.
    • (1997) Arch Dermatol Res , vol.289 , pp. 404-409
    • Fartasch, M.1    Teal, J.2    Menon, G.K.3
  • 20
    • 0026045201 scopus 로고
    • A controlled comparative efficacy study of 5% ammonium lactate lotion versus an emollient control lotion in the treatment of moderate xerosis
    • Wehr RF, Kantor I, Jones EL, McPhee ME, Krochmal L. A controlled comparative efficacy study of 5% ammonium lactate lotion versus an emollient control lotion in the treatment of moderate xerosis. J Am Acad Dermatol 1991; 25:849–851.
    • (1991) J am Acad Dermatol , vol.25 , pp. 849-851
    • Wehr, R.F.1    Kantor, I.2    Jones, E.L.3    McPhee, M.E.4    Krochmal, L.5
  • 21
    • 0026511051 scopus 로고
    • Clinical and non-invasive evalu­ation of 12% ammonium lactate emulsion for the treatment of dry skin in atopic and non-atopic subjects
    • Vilaplana J, Coll J, Trullas C, Azan A, Pelejero C. Clinical and non-invasive evalu­ation of 12% ammonium lactate emulsion for the treatment of dry skin in atopic and non-atopic subjects. Acta Derm Venereol 1992; 72:28–33.
    • (1992) Acta Derm Venereol , vol.72 , pp. 28-33
    • Vilaplana, J.1    Coll, J.2    Trullas, C.3    Azan, A.4    Pelejero, C.5
  • 23
    • 0002211291 scopus 로고
    • Actions of alpha hydroxy acids on skin components
    • Van Scott EJ, Yu RJ. Actions of alpha hydroxy acids on skin components. J Geriatr Dermatol 1995; 3:19A–25A.
    • (1995) J Geriatr Dermatol , vol.3
    • Van Scott, E.J.1    Yu, R.J.2
  • 24
    • 0029029131 scopus 로고
    • The use of glycolic acid as a peeling agent
    • Murad H, Shamban AT, Premo PS. The use of glycolic acid as a peeling agent. Dermatol Clin 1995; 13:285–307.
    • (1995) Dermatol Clin , vol.13 , pp. 285-307
    • Murad, H.1    Shamban, A.T.2    Premo, P.S.3
  • 25
    • 0000080326 scopus 로고
    • The influence of hydroxy-acids on the rheological proper­ties of the stratum corneum
    • Takahashi M, Machida Y. The influence of hydroxy-acids on the rheological proper­ties of the stratum corneum. J Soc Cosmet Chem 1985; 36:177–187.
    • (1985) J Soc Cosmet Chem , vol.36 , pp. 177-187
    • Takahashi, M.1    Machida, Y.2
  • 26
    • 0029608642 scopus 로고
    • Functional changes in human stratum corneum induced by topical glycolic acid: Comparison with all-transretinoic acid
    • Effendy I, Kawangsukstith C, Lee JY, Maibach HI. Functional changes in human stratum corneum induced by topical glycolic acid: comparison with all-trans retinoic acid. Acta Dermatol Venereol 1995; 75:455–458.
    • (1995) Acta Dermatol Venereol , vol.75 , pp. 455-458
    • Effendy, I.1    Kawangsukstith, C.2    Lee, J.Y.3    Maibach, H.I.4
  • 28
    • 0000401189 scopus 로고
    • An alpha-hydroxy acid acts as an antioxidant
    • Perricone NV. An alpha-hydroxy acid acts as an antioxidant. J Geriatr Dermatol 1993; 1:101–104.
    • (1993) J Geriatr Dermatol , vol.1 , pp. 101-104
    • Perricone, N.V.1
  • 29
    • 0032449115 scopus 로고    scopus 로고
    • Modulation of stratum corneum properties by salicylic acid and all-trans-retinoic acid
    • Piérard-Franchimont C, Goffin V, Piérard GE. Modulation of stratum corneum properties by salicylic acid and all-trans-retinoic acid. Skin Pharmacol Appl Physiol 1998; 11:266–272.
    • (1998) Skin Pharmacol Appl Physiol , vol.11 , pp. 266-272
    • Piérard-Franchimont, C.1    Goffin, V.2    Piérard, G.E.3
  • 30
    • 0028710236 scopus 로고
    • Therapeutics: Personal practice. The clinical use of alpha hydroxy acids
    • Rubin MG. Therapeutics: personal practice. The clinical use of alpha hydroxy acids. Aust J Dermatol 1994; 35:29–33.
    • (1994) Aust J Dermatol , vol.35 , pp. 29-33
    • Rubin, M.G.1
  • 31
    • 0025898399 scopus 로고
    • Use of pyruvic acid in the treatment of actinic keratoses: A clinical and histopathologic study
    • Griffin TD, Van Scott EJ. Use of pyruvic acid in the treatment of actinic keratoses: a clinical and histopathologic study. Cutis 1991; 47:325–329.
    • (1991) Cutis , vol.47 , pp. 325-329
    • Griffin, T.D.1    Van Scott, E.J.2
  • 32
    • 0031691921 scopus 로고    scopus 로고
    • The new fluor-hydroxy pulse peel
    • Marrero GM, Katz BE. The new fluor-hydroxy pulse peel. Dermatol Surg 1998; 24:973–978.
    • (1998) Dermatol Surg , vol.24 , pp. 973-978
    • Marrero, G.M.1    Katz, B.E.2
  • 33
    • 1842294624 scopus 로고    scopus 로고
    • Glycolic acid peels in the treatment of melasma among Asian women
    • Lim JTE, Tham SN. Glycolic acid peels in the treatment of melasma among Asian women. Dermatol Surg 1997; 23:177–179.
    • (1997) Dermatol Surg , vol.23 , pp. 177-179
    • Lim, J.T.E.1    Tham, S.N.2
  • 34
    • 0030004467 scopus 로고    scopus 로고
    • The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions
    • Garcia A, Fulton JE. The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions. Dermatol Surg 1996; 22:443–447.
    • (1996) Dermatol Surg , vol.22 , pp. 443-447
    • Garcia, A.1    Fulton, J.E.2
  • 35
    • 0242551880 scopus 로고    scopus 로고
    • Skin-lightening products: Revisited
    • Petit L, Piérard GE. Skin-lightening products: revisited. Int J Cosmet Sci 2003; 25:169–181.
    • (2003) Int J Cosmet Sci , vol.25 , pp. 169-181
    • Petit, L.1    Piérard, G.E.2
  • 36
    • 0022971858 scopus 로고
    • Rational therapy for acne vulgaris: An update on topical treat­ment
    • Leyden JJ, Shalita AR. Rational therapy for acne vulgaris: an update on topical treat­ment. J Am Acad Dermatol 1986; 15:907–914.
    • (1986) J am Acad Dermatol , vol.15 , pp. 907-914
    • Leyden, J.J.1    Shalita, A.R.2
  • 37
    • 0030018554 scopus 로고    scopus 로고
    • The benefit of 2% salicylic acid lotion in acne—a placebo-controlled study
    • Eady EA, Burke BM, Pulling K, Cunliffe WJ. The benefit of 2% salicylic acid lotion in acne—a placebo-controlled study. J Dermatol Treat 1996; 7:93–96.
    • (1996) J Dermatol Treat , vol.7 , pp. 93-96
    • Eady, E.A.1    Burke, B.M.2    Pulling, K.3    Cunliffe, W.J.4
  • 38
    • 0002062958 scopus 로고
    • Alpha hydroxyacids: Therapeutic potentials
    • Van Scott EJ, Yu RJ. Alpha hydroxyacids: therapeutic potentials. Can J Dermatol 1989; 1:108–112.
    • (1989) Can J Dermatol , vol.1 , pp. 108-112
    • Van Scott, E.J.1    Yu, R.J.2
  • 39
    • 0030940462 scopus 로고    scopus 로고
    • The effect of glycolic acid on the treatment of acne in asian skin
    • Wang CM, Huang CL, Hu CTS et al. The effect of glycolic acid on the treatment of acne in asian skin. Dermatol Surg 1997; 23:23–29.
    • (1997) Dermatol Surg , vol.23 , pp. 23-29
    • Wang, C.M.1    Huang, C.L.2    Hu, C.T.S.3
  • 40
    • 0036653654 scopus 로고    scopus 로고
    • Nudging acne by topical beta-lipohydroxy acid (LHA), a new comedolytic agent
    • Piérard GE, Rougier A. Nudging acne by topical beta-lipohydroxy acid (LHA), a new comedolytic agent. Eur J Dermatol 2002; 12:S47–S48.
    • (2002) Eur J Dermatol , vol.12
    • Piérard, G.E.1    Rougier, A.2
  • 41
    • 0037280461 scopus 로고    scopus 로고
    • Comedolysis by a lipohydroxyacid formulation in acne-prone subjects
    • Uhoda E, Piérard-Franchimont C, Pierard GE. Comedolysis by a lipohydroxyacid formulation in acne-prone subjects. Eur J Dermatol 2003; 13:65–68.
    • (2003) Eur J Dermatol , vol.13 , pp. 65-68
    • Uhoda, E.1    Piérard-Franchimont, C.2    Pierard, G.E.3
  • 42
    • 0036654572 scopus 로고    scopus 로고
    • Efficacy and safety of a new salicylic acid derivative as a complement of vitamin A acid in acne treatment
    • Rougier A, Richard A. Efficacy and safety of a new salicylic acid derivative as a complement of vitamin A acid in acne treatment. Eur J Dermatol 2002; 12:S49–S50.
    • (2002) Eur J Dermatol , vol.12
    • Rougier, A.1    Richard, A.2
  • 43
    • 0027374624 scopus 로고
    • Treatment of pseudofolliculitis barbae with topical glycolic acid: A report of two studies
    • Perricone NV. Treatment of pseudofolliculitis barbae with topical glycolic acid: a report of two studies. Cutis 1993; 52:232–235.
    • (1993) Cutis , vol.52 , pp. 232-235
    • Perricone, N.V.1
  • 44
    • 0001802754 scopus 로고
    • Hydroxy acids and skin aging
    • Smith WP. Hydroxy acids and skin aging. Cosmet Toilet 1994; 109:41–44.
    • (1994) Cosmet Toilet , vol.109 , pp. 41-44
    • Smith, W.P.1
  • 45
    • 0042813799 scopus 로고
    • Connective tissue alterations in photoaged skin and the effects of alpha-hydroxy acids
    • Bernstein EF, Uitto J. Connective tissue alterations in photoaged skin and the effects of alpha-hydroxy acids. J Geriatr Dermatol 1995; 3:7A–18A.
    • (1995) J Geriatr Dermatol , vol.3
    • Bernstein, E.F.1    Uitto, J.2
  • 47
    • 0029972868 scopus 로고    scopus 로고
    • Clinical and histological effects of glycolic acid at different concentrations and pH levels
    • Dinardo JC, Grove GL, Moy LS. Clinical and histological effects of glycolic acid at different concentrations and pH levels. Dermatol Surg 1996; 22:421–424.
    • (1996) Dermatol Surg , vol.22 , pp. 421-424
    • Dinardo, J.C.1    Grove, G.L.2    Moy, L.S.3
  • 49
    • 0030063454 scopus 로고    scopus 로고
    • Increased factor XIIIa transglutaminase expression in dermal dendrocytes after treatment with α-hydroxyacids: Potential physiologic significance
    • Griffin TD, Murphy GF, Sueki H, Telegan B, Johnson WC, Ditre CM, Yu RJ, Van Scott EJ. Increased factor XIIIa transglutaminase expression in dermal dendrocytes after treatment with α-hydroxyacids: potential physiologic significance. J Am Acad Dermatol 1996; 34:196–203.
    • (1996) J am Acad Dermatol , vol.34 , pp. 196-203
    • Griffin, T.D.1    Murphy, G.F.2    Sueki, H.3    Telegan, B.4    Johnson, W.C.5    Ditre, C.M.6    Yu, R.J.7    Van Scott, E.J.8
  • 50
    • 0029930918 scopus 로고    scopus 로고
    • Glycolic acid modulation of collagen production in human skin fibroblast cultures in vitro
    • Moy LS, Howe K, Moy RL. Glycolic acid modulation of collagen production in human skin fibroblast cultures in vitro. Dermatol Surg 1996; 22:439–441.
    • (1996) Dermatol Surg , vol.22 , pp. 439-441
    • Moy, L.S.1    Howe, K.2    Moy, R.L.3
  • 51
    • 0029737749 scopus 로고    scopus 로고
    • Epidermal and dermal effects of topical lactic acid
    • Smith WP. Epidermal and dermal effects of topical lactic acid. J Am Acad Dermatol 1996; 35:388–391.
    • (1996) J am Acad Dermatol , vol.35 , pp. 388-391
    • Smith, W.P.1
  • 52
    • 0029994729 scopus 로고    scopus 로고
    • Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photoaged skin
    • Stiller NJ, Bartolone J, Stern R et al. Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photoaged skin. Arch Dermatol 1996; 132:631–635.
    • (1996) Arch Dermatol , vol.132 , pp. 631-635
    • Stiller, N.J.1    Bartolone, J.2    Stern, R.3
  • 53
    • 0030955702 scopus 로고    scopus 로고
    • Improving the appearance of phtoaged skin with glycolic acid
    • Bergfeld W, Tung R, Vidimos A et al. Improving the appearance of phtoaged skin with glycolic acid. J Am Acad Dermatol 1997; 36:1011–1013.
    • (1997) J am Acad Dermatol , vol.36 , pp. 1011-1013
    • Bergfeld, W.1    Tung, R.2    Vidimos, A.3
  • 54
    • 0031759121 scopus 로고    scopus 로고
    • Increased in vivocollagen synthesis and in vitrocell collagen synthesis and in vitrocell proliferative effect ofglycolic acid
    • Kim SJ, Park JH, Kim DH et al. Increased in vivo collagen synthesis and in vitro cell collagen synthesis and in vitro cell proliferative effect ofglycolic acid. Dermatol Surg 1998; 24:1054–1058.
    • (1998) Dermatol Surg , vol.24 , pp. 1054-1058
    • Kim, S.J.1    Park, J.H.2    Kim, D.H.3
  • 55
    • 0026507774 scopus 로고
    • Effects of topical ammonium lactate on cutaneous atrophy from a potent topical corticosteroid
    • Lavker RM, Kaidbey K, Leyden JJ. Effects of topical ammonium lactate on cutaneous atrophy from a potent topical corticosteroid. J Am Acad Dermatol 1992; 26:535–544.
    • (1992) J am Acad Dermatol , vol.26 , pp. 535-544
    • Lavker, R.M.1    Kaidbey, K.2    Leyden, J.J.3
  • 57
    • 0003814435 scopus 로고
    • The utilization of glycolic acid in photoaging
    • Elson ML. The utilization of glycolic acid in photoaging. Cosmet Dermatol 1992; 5:12–15.
    • (1992) Cosmet Dermatol , vol.5 , pp. 12-15
    • Elson, M.L.1
  • 58
    • 0002815102 scopus 로고
    • Aged skin, retinoids, and alpha-hydroxy acids
    • Hermitte R. Aged skin, retinoids, and alpha-hydroxy acids. Cosmet Toilet 1992; 107:63–67.
    • (1992) Cosmet Toilet , vol.107 , pp. 63-67
    • Hermitte, R.1
  • 59
    • 10244248623 scopus 로고
    • Glycolic acid therapy: Evaluation of efficacy and tech­niques in treatment of photodamage lesions
    • Moy LS, Murad H, Moy RL. Glycolic acid therapy: evaluation of efficacy and tech­niques in treatment of photodamage lesions. Am J Cosmet Surg 1993; 10:9–13.
    • (1993) Am J Cosmet Surg , vol.10 , pp. 9-13
    • Moy, L.S.1    Murad, H.2    Moy, R.L.3
  • 61
    • 0030012202 scopus 로고    scopus 로고
    • Clinical improvement of photoaged skin with 50% glycolic acid
    • Newman N, Newman A, Moy LS et al. Clinical improvement of photoaged skin with 50% glycolic acid. Dermatol Surg 1996; 22:455–460.
    • (1996) Dermatol Surg , vol.22 , pp. 455-460
    • Newman, N.1    Newman, A.2    Moy, L.S.3
  • 62
    • 16744368282 scopus 로고    scopus 로고
    • Comparativeeffect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women
    • Piérard GE, Henry F, Piérard-Franchimont C. Comparative effect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women. Maturitas 1996; 23:273–277.
    • (1996) Maturitas , vol.23 , pp. 273-277
    • Piérard, G.E.1    Henry, F.2    Piérard-Franchimont, C.3
  • 65
    • 18844463744 scopus 로고    scopus 로고
    • Comparative effects of reti­noic acid, glycolic acid and a lipophilic derivative of salicylic acid on photodamaged epidermis
    • Piérard GE, Kligman AM, Stoudemayer T, Lévêque JL. Comparative effects of reti­noic acid, glycolic acid and a lipophilic derivative of salicylic acid on photodamaged epidermis. Dermatology 1999; 199:50–53.
    • (1999) Dermatology , vol.199 , pp. 50-53
    • Piérard, G.E.1    Kligman, A.M.2    Stoudemayer, T.3    Lévêque, J.L.4
  • 66
    • 0345195773 scopus 로고
    • The compatibility ofcombinations of glycolic acid and tretinoin in acne and in photodamaged facial skin
    • Kligman AM. The compatibility ofcombinations of glycolic acid and tretinoin in acne and in photodamaged facial skin. J Geriatr Dermatol 1995; 3:25A–28A.
    • (1995) J Geriatr Dermatol , vol.3
    • Kligman, A.M.1
  • 67
    • 0345616397 scopus 로고
    • El lipohidroxiacido y el envejecimiento cutaneo
    • Arrese, JE, Piérard GE. El lipohidroxiacido y el envejecimiento cutaneo. Arch Argent Dermatol 1995; 45:147–150.
    • (1995) Archargent Dermatol , vol.45 , pp. 147-150
    • Arrese, J.E.1    Piérard, G.E.2
  • 68
    • 1842377990 scopus 로고    scopus 로고
    • Dermo-epidermal stimulation elicited by a β-lipohydroxyacid: A comparison with salicylic acid and all-trans-retinoic acid
    • Piérard GE, Nikkels-Tassoudji N, Arrese JE, Piérard-Franchimont C, Lévêque JL. Dermo-epidermal stimulation elicited by a β-lipohydroxyacid: a comparison with salicylic acid and all-trans-retinoic acid. Dermatology 1997; 194:398–401.
    • (1997) Dermatology , vol.194 , pp. 398-401
    • Piérard, G.E.1    Nikkels-Tassoudji, N.2    Arrese, J.E.3    Piérard-Franchimont, C.4    Lévêque, J.L.5
  • 69
    • 0031802339 scopus 로고    scopus 로고
    • Histometric assessment of the age- related skin response to 2-hydroxy-5-octanoyl benzoic acid
    • Avila Camacho M, Montastier C, Piérard GE. Histometric assessment of the age- related skin response to 2-hydroxy-5-octanoyl benzoic acid. Skin Pharmacol Appl Skin Physiol 1998; 11:52–56.
    • (1998) Skin Pharmacol Appl Skin Physiol , vol.11 , pp. 52-56
    • Avila Camacho, M.1    Montastier, C.2    Piérard, G.E.3


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