A novel explanation for acantholysis in pemphigus vulgaris: The basal cell shrinkage hypothesis

Journal of the American Academy of Dermatology

Volumn 54, Issue 3, 2006, Pages 513-516

  Bystryn, Jean Claude ^a   Grando, Sergei A ^b,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOGLEIN 1; DESMOGLEIN 3;

ACANTHOLYSIS; BASAL CELL; CELL ADHESION; DESMOSOME; HUMAN; PATHOPHYSIOLOGY; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; REVIEW;

EID: 32644452893     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2005.12.003     Document Type: Article

References (45)

1. S.M. Burge, C.L. Wilson, D. Dean, and F. Wojnarowska An immunohistological study of desmosomal components in pemphigus Br J Dermatol 128 1993 363 370
2. M. Amagai Adhesion molecules, I: keratinocyte-keratinocyte interactions; cadherins and pemphigus J Invest Dermatol 104 1995 146 152
3. J.R. Stanley Defective cell-cell adhesion in the epidermis Ciba Found Symp 189 1995 107 120
4. M.G. Mahoney, Z. Wang, K. Rothenberger, P.J. Koch, M. Amagai, and J.R. Stanley Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris J Clin Invest 103 1999 461 468
5. M.C. Udey, and J.R. Stanley Pemphigus-diseases of antidesmosomal autoimmunity JAMA 282 1999 572 576
6. K. Hashimoto, and W.F. Lever An electron microscopic study on pemphigus vulgaris of the mouth and the skin with special reference to the intercellular cement J Invest Dermatol 48 1967 540 552
7. K. Hashimoto, and W.F. Lever The intercellular cement in pemphigus vulgaris, an electron microscopic study Dermatologica 135 1967 27 34
8. G.F. Wilgram, J.B. Caulfield, and W.F. Lever An electron microscopic study of acantholysis in pemphigus vulgaris J Invest Dermatol 36 1961 373 382
9. W.M. Sams Jr., and W.R. Gammon Mechanism of lesion production in pemphigus and pemphigoid J Am Acad Dermatol 6 1982 431 452
10. Y. Shirakata, M. Amagai, Y. Hanakawa, T. Nishikawa, and K. Hashimoto Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1 J Invest Dermatol 110 1998 76 78
11. X. Ding, V. Aoki, J.M. Mascaro Jr., A. Lopez-Swiderski, L.A. Diaz, and J.A. Fairley Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles J Invest Dermatol 109 1997 592 596
12. J.C. Bystryn, A. Akman, and D. Jiao Limitations in enzyme-linked immunosorbent assays for antibodies against desmogleins 1 and 3 in patients with pemphigus Arch Dermatol 138 2002 1252 1253
13. M. Amagai, K. Tsunoda, D. Zillikens, T. Nagai, and T. Nishikawa The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile J Am Acad Dermatol 40 1999 167 170
14. N. Sami, K.C. Bhol, and R.A. Ahmed Influence of intravenous immunoglobulin therapy on autoantibody titers to desmoglein 3 and desmoglein 1 in pemphigus vulgaris Eur J Dermatol 13 2003 377 381
15. M.J. Jamora, D. Jiao, and J.C. Bystryn Antibodies to desmoglein 1 and 3, and the clinical phenotype of pemphigus vulgaris J Am Acad Dermatol 48 2003 976 977
16. X. Ding, L.A. Diaz, J.A. Fairley, G.J. Guidice, and Z. Liu The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic J Invest Dermatol 112 1999 739 743
17. Y. Kitajima, S. Inoue, and H. Yaoita Effects of pemphigus antibody on the organization of microtubules and keratin-intermediate filaments in cultured human keratinocytes Br J Dermatol 114 1986 171 179
18. Y. Jinbu, Y. Kitajima, S. Koto, Y. Akasaka, and H. Yaoita Different effects of pemphigus antibody and plasmin on the distribution of keratin intermediate filaments and desmoplakins between cultured oral and epidermal keratinocytes J Dermatol Sci 3 1992 6 12
19. A. Baroni, E. Buommino, I. Paoletti, M. Orlando, E. Ruocco, and V. Ruocco Pemphigus serum and captopril induce heat shock protein 70 and inducible nitric oxide synthase overexpression, triggering apoptosis in human keratinocytes Br J Dermatol 150 2004 1070 1080
20. Lever WF. Pemphigus. Medicine (Baltimore) 1953;32:2-123.
21. C.H. Hu, B. Michel, and J.R. Schiltz Epidermal acantholysis induced in vitro by pemphigus autoantibody: an ultrastructural study Am J Pathol 90 1978 345 361
22. Y. Barlow, and D. Wray Ultrastructural alterations associated with in vivo and in vitro bound pemphigus antibodies in cultured oral epithelial cells J Oral Pathol Med 20 1991 241 244
23. W.F. Lever Pemphigus and pemphigoid 1965 Charles C. Thomas Springfield, Ill
24. S.T. Boyce, and R.G. Ham Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture J Invest Dermatol 81 Suppl 1983 33s-40s
25. P.M. Steiner, and I.M. Freedberg Molecular and cellular biology of keratins L.A. Goldsmith Physiology, biochemistry, and molecular biology of the skin 2nd ed. 1991 Oxford University Press New York 113 147
26. A. Ndoye, R. Buchli, B. Greenberg, V.T. Nguyen, S. Zia, and J.G. Rodriguez Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis J Invest Dermatol 111 1998 410 416
27. Y. Aoyama, M.K. Owada, and Y. Kitajima A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes Eur J Immunol 29 1999 2233 2240
28. V.T. Nguyen, J. Arredondo, A.I. Chernyavsky, Y. Kitajima, M. Pittelkow, and S.A. Grando Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes J Biol Chem 279 2004 2135 2146
29. V.T. Nguyen, J. Arredondo, A.I. Chernyavsky, M.R. Pittelkow, Y. Kitajima, and S.A. Grando Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists Arch Dermatol 140 2004 327 334
30. P. Berkowitz, P. Hu, Z. Liu, L.A. Diaz, J.J. Enghild, and M.P. Chua Desmosome signaling: inhibition of p38MAPK prevents pemphigus vulgaris IgG induced cytoskeleton reorganization J Biol Chem 280 2005 23778 23784
31. C. Esaki, M. Seishima, T. Yamada, K. Osada, and Y. Kitajima Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line J Invest Dermatol 105 1995 329 333
32. M. Seishima, C. Esaki, K. Osada, S. Mori, T. Hashimoto, and Y. Kitajima Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-triphosphate in DJM-1 cells, a squamous cell carcinoma line J Invest Dermatol 104 1995 33 37
33. M. Seishima, Y. Iwasaki-Bessho, Y. Itoh, Y. Nozawa, M. Amagai, and Y. Kitajima Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction Arch Dermatol Res 291 1999 606 613
34. S.A. Grando, B.T. Glukhenky, A.B. Romanenko, and S.V. Demidov Pemphigus antibody-induced intercellular separation of cultivated murine epidermocytes is accompanied by change in ratio of intraepidermocytic cAMP/cGMP 1988 The IV International Congress of Cell Biology Ottawa p. 69
35. M. Seishima, S. Satoh, M. Nojiri, K. Osada, and Y. Kitajima Pemphigus IgG induces expression of urokinase plasminogen activator receptor on the cell surface of cultured keratinocytes J Invest Dermatol 109 1997 650 655
36. Y. Milner, P. Metezeau, H. Kiefer, M. Finemesser, F. Bregegere, and M. Zlotkin Pemphigus an autoimmune disease of the skin: cell-cell separation versus membrane signaling and apoptosis in acantholysis Y. Shoenfeld The decade of autoimmunity 4th ed. 1999 Elsevier Philadelphia 606 615
37. M. Puviani, A. Marconi, E. Cozzani, and C. Pincelli Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8 J Invest Dermatol 120 2003 164 167
38. B. Pelacho, C. Natal, A. Espana, I. Sanchez-Carpintero, M.J. Iraburu, and M.J. Lopez-Zabalza Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes FEBS Lett 566 2004 6 10
39. J. Arredondo, A.I. Chernyavsky, A. Karaouni, and S.A. Grando Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in pemphigus Am J Pathol 167 2005 1531 1544
40. F. Buttgereit, G.R. Burmester, and M.D. Brand Bioenergetics of immune functions: fundamental and therapeutic aspects Immunol Today 21 2000 192 199
41. M.D. Mignogna, L. Lo Muzio, E. Ruoppo, S. Fedele, L. Lo Russo, and E. Bucci High-dose intravenous 'pulse' methylprednisone in the treatment of severe oropharyngeal pemphigus: a pilot study J Oral Pathol Med 31 2002 339 344
42. V.P. Werth Treatment of pemphigus vulgaris with brief, high-dose intravenous glucocorticoids Arch Dermatol 132 1996 1435 1439
43. C. Gooptu, and R.C. Staughton Use of topical cyclosporin in oral pemphigus J Am Acad Dermatol 38 1998 860 861
44. W.A. Orlowski, E. Bressman, J.L. Doyle, and A.I. Chasens Chronic pemphigus vulgaris of the gingiva: a case report with a 6-year follow-up J Periodontol 54 1983 685 689
45. V. Dumas, J.C. Roujeau, P. Wolkenstein, J. Revuz, and A. Cosnes The treatment of mild pemphigus vulgaris and pemphigus foliaceus with a topical corticosteroid Br J Dermatol 140 1999 1127 1129