Intravenous morphine and topical tetracaine for treatment of pain in preterm neonates undergoing central line placement

JAMA

Volumn 295, Issue 7, 2006, Pages 793-800

  Taddio, Anna ^a,b   Lee, Charlene ^a   Yip, Amelia ^a,b   Parvez, Boriana ^c   McNamara, Patrick J ^a   Shah, Vibhuti ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOCAL ANESTHETIC AGENT; MORPHINE; OPIATE; PLACEBO; TETRACAINE;

ANALGESIA; ANALGESIC ACTIVITY; ARTICLE; ARTIFICIAL VENTILATION; BLISTER; BLOOD PRESSURE MONITORING; BRADYCARDIA; CENTRAL VENOUS CATHETERIZATION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DESQUAMATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FACIAL EXPRESSION; FEMALE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN INTENSIVE CARE; PAIN; PAIN ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SKIN BLANCHING; SKIN MANIFESTATION; SKIN REDNESS; VENTILATOR;

EID: 32644442180     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.295.7.793     Document Type: Article

References (21)

1. Health Canada. Perinatal Health Indicators for Canada: A Resource Manual. Ottawa, Ontario: Minister of Public Works and Government Services Canada; 2000.
2. Anand KJS, Johnston CC, Oberlander TF, Taddio A, Tutag Lehr V, Walco GA. Analgesia and local anesthesia during invasive procedures in the neonate. Clin Ther. 2005;27:844-876.
3. Taddio A, Katz J. The effects of early pain experience in neonates on pain responses in infancy and childhood. Paediatr Drugs. 2005;7:245-257.
4. Giacoia GP, Mattison DR. Newborns and drug studies: the NICHD/FDA newborn drug development initiative. Clin Ther. 2005;27:796-813.
5. Anand KJS; International Evidence-Based Group for Neonatal Pain. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med. 2001;155:173-180.
6. Moustogiannis AN, Raju TNK, Roohey T, McCulloch KM. Intravenous morphine attenuates pain induced changes in skin blood flow in newborn infants. Neurol Res. 1996;18:440-444.
7. Garcia OC, Reichberg S, Brion LP, Schulman M. Topical anesthesia for line insertion in very low birth weight infants. J Perinatol. 1997;17:477-480.
8. Ballantyne M, McNair C, Ung E, Gibbins S, Stevens B. A randomized controlled trial evaluating the efficacy of tetracaine gel for pain relief from peripherally inserted central catheters in infants. Adv Neonatal Care. 2003;3:297-307.
9. Craig KD, Grunau RVE. Neonatal pain perception and behavioral measurement. In: Anand KJS, McGrath PJ, eds. Pain in Neonates. London, England: Elsevier; 1993:67-105.
10. Duhn LJ, Medves JM. A systematic integrative review of infant pain assessment tools. Adv Neonatal Care. 2004;4:126-140.
11. Johnston CC, Stevens B, Yang F, Horton L. Differential response to pain by very premature neonates. Pain. 1995;61:471-479.
12. Gibbins S, Stevens B. The influence of gestational age on the efficacy and short-term safety of sucrose for procedural pain relief. Adv Neonatal Care. 2003;3:241-249.
13. Norman GR, Streiner DL. Biostatistics: The Bare Essentials. Toronto, Ontario: Mosby-Year Book Inc; 1994.
14. Brown H. Applied Mixed Models in Medicine. New York, NY: Wiley; 1999.
15. Taddio A, Soin H, Schuh S, Koren G, Scolnik D. A randomized controlled trial of liposomal lidocaine to improve procedural success rates and reduce procedural pain in children. CMAJ. 2005;172:1691-1695.
16. Taddio A, Lee CM, Parvez B, Koren G, Shah V. Contact dermatitis and bradycardia in a preterm infant given tetracaine 4% gel. Ther Drug Monit. In press.
17. Lemyre B, Sherlock RL, Hogan D, Blanchard C, Moher D. Does Ametop 4% gel reduce procedural pain in infants during a peripherally-inserted central catheter: a randomized, double-blind, placebo controlled trial [abstract 130]. J Paediatr Child Health. 2005;19(suppl B):53B.
18. Anand KJS, Hall RW, Desal N, et al. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. Lancet. 2004;363:1673-1682.
19. O'Brien L, Taddio A, Lyszkiewicz DA, Koren G. A critical review of the topical local anesthetic amethocaine (Ametop) for pediatric pain. Paediatr Drugs. 2005;7:41-54.
20. Schulz KF. Subverting randomization in controlled trials. JAMA. 1995;274:1456-1458.
21. Alderson P. Absence of evidence is not evidence of absence. BMJ. 2004;328:476-477.