Cell cycle kinetic changes induced by interleukin-3 and interleukin-6 during ex vivo expansion of mobilized peripheral blood CD34 cells

Haematologica

Volumn 91, Issue 1, 2006, Pages 121-124

  Sanchez Garcia, Joaquin ^a   Torres, Antonio ^a   Herrera, Concepcion ^a   Alvarez, Miguel A ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Ex vivo expansion; Peripheral blood CD34+ cells; PKH26 Cell tracking; Quiescent cells

Indexed keywords

CD34 ANTIGEN; INTERLEUKIN 3; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; HUMAN; HUMAN CELL; NONHUMAN; PERIPHERAL BLOOD STEM CELL; POPULATION DYNAMICS;

ANTIGENS, CD34; BLOOD CELLS; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL PROLIFERATION; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; INTERLEUKIN-6; KINETICS;

EID: 32544453389     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Brugger W, Scheding S, Ziegler B, Buhring HJ, Kanz L. Ex vivo expansion of hematopoietic stem and progenitor cells. Semin Hematol 2000;37:42-9.
2. Heike T, Nakahata T. Ex vivo expansion of hematopoietic stem cells by cytokines. Biochem Biophys Acta 2002;1592:313-21.
3. McNiece I, Briddell R. Ex vivo expansion of hematopoietic progenitor cells and mature cells. Exp Hematol 2001; 29:3-11.
4. Engelhardt M, Douville J, Behringer D, Jahne A, Smith A, Henschler R, et al. Hematopoietic recovery of ex vivo perfusion culture expanded bone marrow and unexpanded peripheral blood progenitors after myeloablative chemotherapy. Bone Marrow Transplant 2001;27:249-59.
5. Stiff P, Chen B, Franklin W, Oldenberg D, Hsi E, Bayer R, et al. Autologous transplantation of ex vivo expanded bone marrow cells grown from small aliquots after high-dose chemotherapy for breast cancer. Blood 2000;95:2169-74.
6. Pecora AL. Progress in clinical application of use of progenitor cells expanded with hematopoietic growth factors. Curr Opin Hematol 2001;8:141-8.
7. Shih CC, DiGiusto D, Forman SJ. Ex vivo expansion of transplantable human hematopoietic stem cells: where do we stand in the year 2000? J Hematother Stem Cell Res 2000;9:621-8.
8. Herrera C, Sanchez J, Torres A, Bellido C, Rueda A, Alvarez MA. Early acting cytokine-driven ex vivo expansion of mobilized peripheral blood CD34+ cells generates post-mitotic offspring with preserved engraftment ability in non-obese diabetic/severe combined immunodeficient mice. Br J Haematol 2001;114:920-30.
9. Herrera C, Sanchez J, Torres A, Pascual A, Rueda A, Alvarez MA. Pattern of expression of CXCR4 and adhesion molecules by human CD34+ cells from different sources: role in homing efficiency in NOD/SCID mice. Haematologica 2004;89:1037-45.
10. Oostendorp RAJ, Audet J, Miller C, Eaves CJ. Cell division tracking and expansion of hematopoietic long-term repopulating cells. Leukemia 1999;13: 499-501.
11. Srour EF. Proliferative history and hematopoietic function of ex vivo expanded human CD34+ cells. Blood 2000;96:1609-12.
12. Yan F, Collector MI, Tyszko S, Sharkis SJ. Using divisional history to measure hematopoietic stem cell self-renewal and differentiation. Exp Hematol 2003; 31:56-64.
13. Srour EF, Jetmore A, Wolber, FM, Plett PA, Abonour R, Yoder MC, et al. Homing, cell cycle kinetics and fate of transplanted hematopoietic stem cells. Leukemia 2001;15:1681-4.
14. Gothot A, van der Loo JCM, Clapp DW, Srour EF. Cell cycle-related changes in repopulating capacity of human mobilized peripheral blood CD34+ cells in non-obese diabetic/severe combined immune-deficient mice. Blood 1998;92:2641-9.
15. Jetmore A, Plett PA, Tong X, Wolber FM, Breese R, Abonour R, et al. Homing efficiency, cell cycle kinetics and survival of quiescent and cycling human CD34+ cells transplanted into conditioned NOD/SICD recipients. Blood 2002;99:1585-93.
16. Levac K, Karanau F, Bathia M. Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo. Haematologica 2006;90:166-72.
17. Ueda T, Tsuji H, Yoshino Y, Ebihara H, Yagasaki H, Hisakawa H, et al. Expansion of human NOD/SCID-repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL-6 and soluble IL-6 receptor. J Clin Invest 2000;105:1013-21.
18. Yonemura Y, Ku H, Hirayama F, Souza LM, Ogawa M. Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells. Proc Natl Acad Sci USA 1996;93:4040-4.
19. Bryder D, Jacobsen SEW. Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro. Blood 2000;96:1748-55.
20. Robmanith T, Schröder B, Bug G, Muller P, Klenner T, Knaus R, et al. Interleukin 3 improves the ex vivo expansion of primitive human cord blood progenitor cells and maintains the engraftment potential of SCID repopulating cells. Stem Cells 2001;19: 313-20.