Ex vivo expansion of hematopoietic progenitor cells and mature cells

Experimental Hematology

Volumn 29, Issue 1, 2001, Pages 3-11

  McNiece, Ian ^a   Briddell, Robert ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b AMGEN INC   (United States)

Author keywords

Cord blood; Expansion; Progenitors; Stem cells; Transplantation

Indexed keywords

ERYTHROPOIETIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; HEMOPOIETIC GROWTH FACTOR; INTERLEUKIN 3; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR;

BABOON; CELL MATURATION; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL; TARGET CELL; TISSUE EXPANSION; UMBILICAL CORD BLOOD;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL AGING; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL DIVISION; CLINICAL TRIALS; COHORT STUDIES; FETAL BLOOD; GRAFT SURVIVAL; HEMATOPOIESIS; HEMATOPOIETIC CELL GROWTH FACTORS; HEMATOPOIETIC STEM CELLS; HUMANS; PAPIO;

EID: 0035182777     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(00)00610-X     Document Type: Review

References (39)

1. How many cell-generations?
2. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers
3. Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay
4. Colony-forming cells with high proliferative potential (HPP-CFC)
5. Haematopoietic stem cells are organized for use on the basis of their generation-age
6. Nature of the hematopoietic stem cell compartment and its proliferative potential
7. The relationship between the spleen colony-forming cell and the hematopoietic stem cell
8. A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium
9. Subpopulations of mouse bone marrow high-proliferative-potential colony-forming cells
10. Generation of murine hematopoietic precursor cells from macrophage high-proliferative-potential colony-forming cells
11. Synergistic interactions of human growth factors in in vitro cultures of human bone marrow cells
12. - cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor
13. + cells into the myeloid lineage
14. + hematopoietic progenitor cells for transplantation
15. + cells is essential for optimal ex vivo expansion of umbilical cord blood cells
16. High purity of blast cells in CD34 selected populations are essential for optimal ex vivo expansion of human GM-CFC
17. Clinical scale ex vivo expansion of myeloid progenitor cells and megakaryocytes under GMP conditions
18. Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential
19. + peripheral blood cells (PBC) for 10 days in G-CSF, MGDF and SCF prior to transplantation decreased post-transplant neutropenia in baboons
20. Enhanced marrow recovery by short preincubation of marrow allografts with human recombinant interleukin-3 and granulocyte-macrophage colony-stimulating factor
21. Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo
22. + cells in autologous stem cell transplantation for breast cancer
23. + cells isolated from cryopreserved peripheral-blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity
24. + cells
25. Placental and/or umbilical cord blood; an alternative source of hematopoietic stem cells for transplantation
26. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from an HLA-identical sibling
27. Newborn blood can engraft adult mice without inducing graft versus host disease across non H-2 antigens
28. Outcome of cord-blood transplantation from related and unrelated donors
29. Placenta blood as a source of hematopoietic stem cells for transplantation into unrelated recipients
30. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors; analysis of engraftment and acute graft-versus-host disease
31. + cells is essential for optimal ex vivo expansion of umbilical cord blood cells
32. Transplantation of cancer patients receiving high dose chemotherapy with ex vivo expanded cord blood cells
33. A phase I trial of augmentation of unrelated umbilical cord blood transplantation with ex-vivo expanded cells
34. Umbilical cord blood transplants in adults using a combination of unexpanded and ex vivo expanded cells; preliminary clinical observations
35. Transplantation of ex vivo perfusion culture expanded bone marrow cells produces durable hematopoietic reconstitution after myeloablative chemotherapy