Kinetic analysis on the skin disposition of cytotoxicity as an index of skin irritation produced by cetylpyridinium chloride: Comparison of in vitro data using a three-dimensional cultured human skin model with in vivo results in hairless mice

Pharmaceutical Research

Volumn 23, Issue 2, 2006, Pages 329-335

  Kano, Satoshi ^a,b   Sugibayashi, Kenji ^a  

^a JOSAI UNIVERSITY   (Japan)

^b Maruho Co   (Japan)

Author keywords

Cetylpyridinium chloride; Kinetics; Living skin equivalent high; MTT assay; Skin irritation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CATIONIC SURFACTANT; CETYLPYRIDINIUM SALT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; CALORIMETRY; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DERMATOLOGY; EVALUATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN CELL; SKIN IRRITATION; STRATUM CORNEUM; THREE DIMENSIONAL IMAGING; TOXICITY TESTING; TOXICOKINETICS;

ALGORITHMS; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CETYLPYRIDINIUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DERMIS; DETERGENTS; EPIDERMIS; HUMANS; IRRITANTS; KINETICS; MALE; MICE; MICE, INBRED HRS; SKIN; SPECTROPHOTOMETRY, ULTRAVIOLET; SUCCINATE DEHYDROGENASE; TETRAZOLIUM SALTS; THIAZOLES;

EID: 32544439874     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-006-9141-z     Document Type: Article

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