-
5
-
-
0029908558
-
-
E. Georges-Labousse, N. Messaddeq, G. Yehia, L. Cadalbert, A. Dierich, and M. LeMeur Nature Gen. 13 1996 370 373
-
(1996)
Nature Gen.
, vol.13
, pp. 370-373
-
-
Georges-Labousse, E.1
Messaddeq, N.2
Yehia, G.3
Cadalbert, L.4
Dierich, A.5
Lemeur, M.6
-
12
-
-
4544384606
-
-
P.J. Coleman, K.M. Brashear, B.C. Askew, J.H. Hutchinson, C.A. McVean, L.T. Duong, B.P. Feuston, C. Fernandez-Metzler, M.A. Gentile, G.D. Hartman, D.B. Kimmel, C.-T. Leu, L. Lipfert, K. Merkle, B. Pennypacker, T. Prueksaritanont, G.A. Rodan, G.A. Wesolowski, S.B. Rodan, and M.E. Duggan J. Med. Chem. 47 2004 4829 4837
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4829-4837
-
-
Coleman, P.J.1
Brashear, K.M.2
Askew, B.C.3
Hutchinson, J.H.4
McVean, C.A.5
Duong, L.T.6
Feuston, B.P.7
Fernandez-Metzler, C.8
Gentile, M.A.9
Hartman, G.D.10
Kimmel, D.B.11
Leu, C.-T.12
Lipfert, L.13
Merkle, K.14
Pennypacker, B.15
Prueksaritanont, T.16
Rodan, G.A.17
Wesolowski, G.A.18
Rodan, S.B.19
Duggan, M.E.20
more..
-
13
-
-
0032722766
-
-
M.W. Lark, G.B. Stroup, S.M. Hwang, I.E. James, D.J. Rieman, F.H. Drake, J.N. Bradbeer, A. Mathur, K.F. Erhard, K.A. Newlander, S.T. Ross, K.L. Salyers, B.R. Smith, W.H. Miller, W.F. Huffman, and M. Gowen J. Pharmacol. Exp. Ther. 291 1999 612 617
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.291
, pp. 612-617
-
-
Lark, M.W.1
Stroup, G.B.2
Hwang, S.M.3
James, I.E.4
Rieman, D.J.5
Drake, F.H.6
Bradbeer, J.N.7
Mathur, A.8
Erhard, K.F.9
Newlander, K.A.10
Ross, S.T.11
Salyers, K.L.12
Smith, B.R.13
Miller, W.H.14
Huffman, W.F.15
Gowen, M.16
-
14
-
-
0034642586
-
-
W.H. Miller, D.P. Alberts, P.K. Bhatnagar, W.E. Bondinell, J.F. Callahan, R.R. Calvo, R.D. Cousins, K.F. Erhard, D.A. Heerding, R.M. Keenan, C. Kwon, P.J. Manley, K.A. Newlander, S.T. Ross, J.M. Samanen, I.N. Uzinskas, J.W. Venslavsky, C.C.-K. Yuan, R.C. Haltiwanger, M. Gowen, S.-W. Hwang, I.E. James, M.W. Lark, D.J. Rieman, G.B. Stroup, L.M. Azzarano, K.L. Salyers, B.R. Smith, K.W. Ward, K.O. Johanson, and W.F. Huffman J. Med. Chem. 43 2000 22 26
-
(2000)
J. Med. Chem.
, vol.43
, pp. 22-26
-
-
Miller, W.H.1
Alberts, D.P.2
Bhatnagar, P.K.3
Bondinell, W.E.4
Callahan, J.F.5
Calvo, R.R.6
Cousins, R.D.7
Erhard, K.F.8
Heerding, D.A.9
Keenan, R.M.10
Kwon, C.11
Manley, P.J.12
Newlander, K.A.13
Ross, S.T.14
Samanen, J.M.15
Uzinskas, I.N.16
Venslavsky, J.W.17
Yuan, C.C.-K.18
Haltiwanger, R.C.19
Gowen, M.20
Hwang, S.-W.21
James, I.E.22
Lark, M.W.23
Rieman, D.J.24
Stroup, G.B.25
Azzarano, L.M.26
Salyers, K.L.27
Smith, B.R.28
Ward, K.W.29
Johanson, K.O.30
Huffman, W.F.31
more..
-
16
-
-
1542353892
-
-
L. Belvisi, A. Bernardi, A. Checchia, L. Manzoni, D. Potenza, C. Scolastico, M. Castorina, A. Capelli, G. Giannini, P. Carminati, and C. Pisano Org. Lett. 3 2001 1001 1004
-
(2001)
Org. Lett.
, vol.3
, pp. 1001-1004
-
-
Belvisi, L.1
Bernardi, A.2
Checchia, A.3
Manzoni, L.4
Potenza, D.5
Scolastico, C.6
Castorina, M.7
Capelli, A.8
Giannini, G.9
Carminati, P.10
Pisano, C.11
-
17
-
-
14444269454
-
-
M.J. Fisher, B. Gunn, C.S. Harms, A.D. Kline, J.T. Mullaney, A. Nunes, R.M. Scarborough, A.E. Arfsten, M.A. Skelton, S.L. Um, B.G. Uttenback, and J.A. Jakubowski J. Med. Chem. 40 1997 2085 2101
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2085-2101
-
-
Fisher, M.J.1
Gunn, B.2
Harms, C.S.3
Kline, A.D.4
Mullaney, J.T.5
Nunes, A.6
Scarborough, R.M.7
Arfsten, A.E.8
Skelton, M.A.9
Um, S.L.10
Uttenback, B.G.11
Jakubowski, J.A.12
-
18
-
-
0038702062
-
-
M.J. Breslin, M.E. Duggan, W. Halczenko, C. Fernandez-Metzler, C.A. Hunt, C.-T. Leu, K.M. Merkle, A.M. Naylor-Olsen, T. Prueksaritanont, G. Stump, A. Wallace, S.B. Rodan, and J.H. Hutchinson Bioorg. Med. Chem. Lett. 13 2003 1809 1812
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1809-1812
-
-
Breslin, M.J.1
Duggan, M.E.2
Halczenko, W.3
Fernandez-Metzler, C.4
Hunt, C.A.5
Leu, C.-T.6
Merkle, K.M.7
Naylor-Olsen, A.M.8
Prueksaritanont, T.9
Stump, G.10
Wallace, A.11
Rodan, S.B.12
Hutchinson, J.H.13
-
19
-
-
0037420818
-
-
E. Bourguet, J.-L. Banares, J. Parello, X. Lusinghi, J.-P. Girare, and J.-P. Vidal Bioorg. Med. Chem. Lett. 13 2003 1561 1564
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1561-1564
-
-
Bourguet, E.1
Banares, J.-L.2
Parello, J.3
Lusinghi, X.4
Girare, J.-P.5
Vidal, J.-P.6
-
20
-
-
0344064881
-
-
J.J. Perkins, L.T. Duong, C. Fernandez-Metzler, G.D. Hartman, D.B. Kimmel, C.-T. Leu, J.J. Lynch, T. Prueksaritanont, G.A. Rodan, S.B. Rodan, M.E. Duggan, and R.S. Meissner Bioorg. Med. Chem. Lett. 13 2003 4285 4288
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 4285-4288
-
-
Perkins, J.J.1
Duong, L.T.2
Fernandez-Metzler, C.3
Hartman, G.D.4
Kimmel, D.B.5
Leu, C.-T.6
Lynch, J.J.7
Prueksaritanont, T.8
Rodan, G.A.9
Rodan, S.B.10
Duggan, M.E.11
Meissner, R.S.12
-
21
-
-
4544277795
-
-
S. Biltresse, M. Attolini, G. Dive, A. Cordi, G.C. Tucker, and J. Marchand-Brynaert Bioorg. Med. Chem. 12 2004 5379 5393
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 5379-5393
-
-
Biltresse, S.1
Attolini, M.2
Dive, G.3
Cordi, A.4
Tucker, G.C.5
Marchand-Brynaert, J.6
-
22
-
-
20044370258
-
-
A.E. Zartman, L.T. Duong, C. Fernandez-Metzler, G.D. Hartman, C.-T. Leu, T. Prueksaritanont, G.A. Rodan, S.B. Rodan, M.E. Duggan, and R.S. Meissner Bioorg. Med. Chem. Lett. 15 2005 1647 1650
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 1647-1650
-
-
Zartman, A.E.1
Duong, L.T.2
Fernandez-Metzler, C.3
Hartman, G.D.4
Leu, C.-T.5
Prueksaritanont, T.6
Rodan, G.A.7
Rodan, S.B.8
Duggan, M.E.9
Meissner, R.S.10
-
23
-
-
0031661586
-
-
K.C. Nicolaou, J.I. Trujillo, B. Jandeleit, K. Chibale, M. Rosenfeld, B. Diefenbach, D.A. Cheresh, and S.L. Goodman Bioorg. Med. Chem. 6 1998 1185 1208
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 1185-1208
-
-
Nicolaou, K.C.1
Trujillo, J.I.2
Jandeleit, B.3
Chibale, K.4
Rosenfeld, M.5
Diefenbach, B.6
Cheresh, D.A.7
Goodman, S.L.8
-
24
-
-
0034642555
-
-
W.J. Pitts, J. Wityak, J.M. Smallheer, A.E. Tobin, J.W. Jetter, J.W. Buynitsky, P.P. Harlow, K.A. Solomon, M.A. Corjay, S.A. Mousa, R.R. Wexler, and P.K. Jadhav J. Med. Chem. 43 2000 27 40
-
(2000)
J. Med. Chem.
, vol.43
, pp. 27-40
-
-
Pitts, W.J.1
Wityak, J.2
Smallheer, J.M.3
Tobin, A.E.4
Jetter, J.W.5
Buynitsky, J.W.6
Harlow, P.P.7
Solomon, K.A.8
Corjay, M.A.9
Mousa, S.A.10
Wexler, R.R.11
Jadhav, P.K.12
-
25
-
-
0032497431
-
-
B.R. Neustad, E.M. Smith, N. Lindo, T. Nechuta, A. Bronnenkant, A. Wu, L. Armstrong, and C. Kumar Bioorg. Med. Chem. Lett. 8 1998 2395 2398
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 2395-2398
-
-
Neustad, B.R.1
Smith, E.M.2
Lindo, N.3
Nechuta, T.4
Bronnenkant, A.5
Wu, A.6
Armstrong, L.7
Kumar, C.8
-
26
-
-
2442600306
-
-
G. Cardillo, S. Fabbroni, L. Gentilucci, R. Perciaccante, F. Piccinelli, and A. Tolomelli Tetrahedron 60 2004 5031 5040
-
(2004)
Tetrahedron
, vol.60
, pp. 5031-5040
-
-
Cardillo, G.1
Fabbroni, S.2
Gentilucci, L.3
Perciaccante, R.4
Piccinelli, F.5
Tolomelli, A.6
-
27
-
-
32444436081
-
-
note
-
Compound 1 was prepared starting from 2-bromo-3-methyl-2-butenoyl chloride and N-benzyl imine following the procedure reported later for 9a-9b.
-
-
-
-
28
-
-
0032834150
-
-
S. Caltabiano, W.T. Hum, G.J. Attwell, D.N. Gralnick, L.J. Budman, A.M. Cannistraci, and F. Bex J. Biochem. Pharmacol. 58 1999 1567 1578
-
(1999)
J. Biochem. Pharmacol.
, vol.58
, pp. 1567-1578
-
-
Caltabiano, S.1
Hum, W.T.2
Attwell, G.J.3
Gralnick, D.N.4
Budman, L.J.5
Cannistraci, A.M.6
Bex, F.7
-
31
-
-
0001740156
-
-
L.A. Paquette John Wiley New York
-
J.A. Hyatt, and P.W. Raynolds L.A. Paquette Organic Reactions Vol. 45 1994 John Wiley New York 159 646
-
(1994)
Organic Reactions
, vol.45
, pp. 159-646
-
-
Hyatt, J.A.1
Raynolds, P.W.2
-
34
-
-
0029591761
-
-
H. Fujii, H. Komazawa, H. Mori, M. Kojima, I. Itoh, J. Murata, I. Azuma, and I. Saiki Biol. Pharm. Bull. 18 1995 1681 1688
-
(1995)
Biol. Pharm. Bull.
, vol.18
, pp. 1681-1688
-
-
Fujii, H.1
Komazawa, H.2
Mori, H.3
Kojima, M.4
Itoh, I.5
Murata, J.6
Azuma, I.7
Saiki, I.8
-
35
-
-
32444434889
-
-
note
-
The three-dimensional model of compound 9a was generated by HYPERCHEM 7.0 package, using AMBER force field. The model of the inhibitor was manually docked into the active site on the basis of docking studies for the binding of RGD active ligands.
-
-
-
-
36
-
-
0037023363
-
-
J.-P. Xiong, T. Stehle, R. Zhang, A. Joachimiak, M. Frach, S.L. Goodman, and M.A. Arnaout Science 296 2002 151 155 PDB file deposited with code 1L5G
-
(2002)
Science
, vol.296
, pp. 151-155
-
-
Xiong, J.-P.1
Stehle, T.2
Zhang, R.3
Joachimiak, A.4
Frach, M.5
Goodman, S.L.6
Arnaout, M.A.7
-
37
-
-
0141958105
-
-
L. Marinelli, A. Lavecchia, K.-E. Gottschalk, E. Novellino, and H. Kessler J. Med. Chem. 46 2003 4393 4404
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4393-4404
-
-
Marinelli, L.1
Lavecchia, A.2
Gottschalk, K.-E.3
Novellino, E.4
Kessler, H.5
|