Supercritical fluid chromatography/tandem mass spectrometric method for analysis of pharmaceutical compounds in metabolic stability samples

Journal of Pharmaceutical and Biomedical Analysis

Volumn 40, Issue 3, 2006, Pages 799-804

  Hsieh, Yunsheng ^a   Favreau, Leonard ^a   Schwerdt, John ^a   Cheng, K C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Metabolic stability study; Pharmaceuticals; Supercritical fluid chromatography; Tandem mass spectrometry

Indexed keywords

CLOZAPINE; ONDANSETRON; PRIMIDONE; TOLBUTAMIDE;

ANIMAL CELL; ARTICLE; DRUG METABOLISM; DRUG STABILITY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NEBULIZER; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERCRITICAL FLUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; INDICATORS AND REAGENTS; MASS SPECTROMETRY; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; RATS;

EID: 32444448671     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.06.032     Document Type: Article

References (25)

1. K.A. Cox, R.E. White, and W.A. Korfmacher Comb. Chem. High Throughput Screen. 5 2002 29 37
2. E. Gelpi J. Mass Spectrom. 37 2002 241 253
3. T. Wang, M. Barber, I. Hardt, and D.B. Kassel Rapid Commun. Mass Spectrom. 15 2001 2067 2075
4. Y. Hsieh APPI: a new ionization source for LC-MS/MS assays W. Korfmacher Using Mass Spectrometry for Drug Metabolism Studies 2005 CRC Press Boca Raton, FL (Chapter 9)
5. W.A. Korfmacher, K.A. Cox, M.S. Bryant, J. Veals, K. Ng, R. Watkins, and C. Lin Drug Discov. Today 2 1997 532 537
6. Y. Hsieh, M. Chintala, H. Mei, J. Agans, J. Brisson, K. Ng, and W.A. Korfmacher Rapid Commun. Mass Spectrom. 15 2001 2481 2487
7. Y. Hsieh, G. Wang, J. Brisson, K. Ng, and W. Korfmacher J. Pharm. Biomed. Anal. 33 2003 251 261
8. Y. Hsieh Direct plasma injection systems W. Korfmacher Using Mass Spectrometry for Drug Metabolism Studies 2005 CRC Press Boca Raton, FL (Chapter 5)
9. Y. Hsieh, G. Wang, Y. Wang, S. Chackalamannil, K. Ng, and W.A. Korfmacher Anal. Chem. 75 2003 1812 1818
10. Y. Hsieh, M. Bryant, J. Brisson, K. Ng, and W.A. Korfmacher J. Chromatogr. B 767 2002 353 362
11. Y. Hsieh, K. Ng, and W.A. Korfmacher Am. Pharm. Rev. 5 2002 88 92
12. G. Wang, J. Brisson, and Y. Hsieh Am. Pharm. Rev. 6 2003 14 20
13. Y. Hsieh, G. Wang, Y. Wang, S. Chackalamannil, J. Brisson, K. Ng, and W. Korfmacher Rapid Commun. Mass Spectrom. 16 2002 944 950
14. Y. Hsieh, K. Merkle, and G. Wang Rapid Commun. Mass Spectrom. 17 2003 1775 1780
15. Y. Zhao, G. Woo, S. Thomas, D. Semin, and P. Sandra J. Chromatogr. A 1003 2003 157 166
16. J.B. Crowther, and J.D. Henion Anal. Chem. 57 1985 2711 2716
17. K. Dost, D.C. Jones, R. Auerbach, and G. Davidson Analyst 125 2000 1751 1755
18. K. Dost, and G. Davidson Analyst 128 2003 1037 1042
19. D.C. Jones, K. Dost, G. Davidson, and M.W. George Analyst 124 1999 827 831
20. K. Dost, D.C. Jones, and G. Davidson Analyst 125 2000 1243 1247
21. A. Ceccato, F. Vanderbist, J.-Y. Pabst, and B. Streel J. Chromatogr. B 748 2000 65 76
22. T. Ward, and A.B. Farris J. Chromtogr. A 906 2001 73 89
23. W. Zou, J.G. Dorsey, and T.L. Chester Anal. Chem. 72 2000 3620 3626
24. G. Wang, Y. Hsieh, and W. Korfmacher Anal. Chem. 77 2005 541 548
25. J.P. Rauha, H. Vuorela, and R. Kostiainen J. Mass Spectrom. 36 2001 1269 1280