The Brucella abortus xthA-1 gene product participates in base excision repair and resistance to oxidative killing but is not required for wild-type virulence in the mouse model

Journal of Bacteriology

Volumn 188, Issue 4, 2006, Pages 1295-1300

  Hornback, Michael L ^a   Roop II, R Martin ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; CROSS LINKING REAGENT; EXODEOXYRIBONUCLEASE III; GENE PRODUCT; LINSIDOMINE; MESYLIC ACID METHYL ESTER; MITOMYCIN C; PROTEIN XTHA 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BRUCELLA ABORTUS; CELL SURVIVAL; DNA REPAIR; ESCHERICHIA COLI; EXCISION REPAIR; FEMALE; MACROPHAGE; MOUSE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHENOTYPE; PLASMID; PRIORITY JOURNAL; SPLEEN; WILD TYPE; XTHA 1 GENE;

ANIMALS; BACTERIAL PROTEINS; BRUCELLA ABORTUS; BRUCELLOSIS; DNA DAMAGE; DNA REPAIR; DNA, BACTERIAL; ENZYME INHIBITORS; EXODEOXYRIBONUCLEASES; FEMALE; HYDROGEN PEROXIDE; METHYL METHANESULFONATE; MICE; MICE, INBRED BALB C; MOLSIDOMINE; MUTAGENS; OXIDANTS; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); BRUCELLA MELITENSIS BIOVAR ABORTUS; ESCHERICHIA COLI; MURINAE;

EID: 32444438285     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.188.4.1295-1300.2006     Document Type: Article

References (33)

1. Buchmeier, N. A., S. J. Libby, Y. Xu, P. C. Loewen, J. Switala, D. G. Guiney, and F. C. Fang. 1995. DNA repair is more important than catalase for Salmonella virulence in mice. J. Clin. Investig. 95:1047-1053.
2. Burger, R. M., K. Drlica, and B. Birdsall. 1994. The DNA cleavage pathway of iron bleomycin. Strand scission precedes deoxyribose 3-phosphate bond cleavage. J. Biol. Chem. 269:25978-25985.
3. Cunningham, R. P., S. M. Saporito, S. G. Spitzer, and B. Weiss. 1986. Endonuclease IV (nfo) mutant of Escherichia coli. J. Bacteriol. 168:1120-1127.
4. Davies, K. J., and S. W. Lin. 1988. Degradation of oxidatively denatured proteins in Escherichia coli. Free Radic. Biol. Med. 5:215-223.
5. DelVecchio, V. G., V. Kapatral, R. J. Redkar, G. Patra, C. Mujer, T. Los, N. Ivanova, I. Anderson, A. Bhattacharyya, A. Lykidis, G. Reznik, L. Jablonski, N. Larsen, M. D'Souza, A. Bernal, M. Mazur, E. Goltsman, E. Selkov, P. H. Elzer, S. Hagius, D. O'Callaghan, J. J. Letesson, R. Haselkorn, N. Kyrpides, and R. Overbeek. 2002. The genome sequence of the facultative intracellular pathogen Brucella melitensis. Proc. Natl. Acad. Sci. USA 99:443-448.
6. Demple, B., J. Halbrook, and S. Linn. 1983. Escherichia coli xth mutants are hypersensitive to hydrogen peroxide. J. Bacteriol. 153:1079-1082.
7. Demple, B., Y. Daikh, J. Greenberg, and A. Johnson. 1985. Alkylation and oxidative damages to DNA: constitutive and inducible repair systems, p. 205-218. In D. M. Schenkel, P. E. Hartman, T. Kada, and A. Hollaender (ed.), Antimutagenesis and anticarcinogenesis: mechanisms. Plenum Press, New York, N.Y.
8. Edwards, K. M., M. H. Cynamon, R. K. R. Voladri, C. C. Hager, M. S. DeStefano, K. T. Tham, D. L. Lakey, M. R. Bochan, and D. S. Kernodle. 2001. Iron-cofactored superoxide dismutase inhibits host responses to Mycobacterium tuberculosis. Am. J. Respir. Crit. Care Med. 164:2213-2219.
9. Elzer, P. H., R. W. Phillips, M. E. Kovach, K. M. Peterson, and R. M. Roop II. 1994. Characterization and genetic complementation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant. Infect. Immun. 62:4135-4139.
10. Epe, B., D. Ballmaier, I. Roussyn, K. Briviba, and H. Sies, 1996. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res. 24:4105-4110.
11. Fair, S. B., and T. Kogoma. 1991. Oxidative stress responses in Escherichia coli and Salmonella typhimurium. Microbiol. Rev. 55:561-585.
12. Gee, J. M., M. W. Valderas, M. E. Kovach, V. K. Grippe, G. T. Robertson, W.-L. Ng, J. M. Richardson, M. E. Winkler, and R. M. Roop II. 2005. The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice. Infect. Immun. 73:2873-2880.
13. Gerhardt, P. 1958. The nutrition of brucellae. Bacteriol. Rev. 22:81-98.
14. Halling, S. M., B. D. Peterson-Burch, B. J. Bricker, R. L. Zuerner, Z. Qing, L. L. Li, V. Kapur, D. P. Alt, and S. C. Olsen. 2005. Completion of the genome sequence of Brucella abortus and comparison of the highly similar genomes of Brucella melitensis and Brucella suis. J. Bacteriol. 187:2715-2726.
15. Haring, M., H. Rudiger, B. Demple, S. Boiteux, and B. Epe. 1994. Recognition of oxidized abasic sites by repair endonucleases. Nucleic Acids Res. 22:2010-2015.
16. -) by various mutagens. Mutat. Res. 27:27-44.
17. Jiang, X., B. Leonard, R. Benson, and C. L. Baldwin. 1993. Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide. Cell. Immunol. 151:309-319.
18. Kirtikar, D. M., G. R. Cathcart, J. G. White, I. Ukstins, and D. A. Goldthwait. 1977. Mutations in Escherichia coli altering an apurinic endonuclease, endonuclease II, and exonuclease III and their effect on in vivo sensitivity to methylmethanesulfonate. Biochemistry 16:5625-5631.
19. Levin, J. D., and B. Demple. 1996. In vitro detection of endonuclease IV-specific DNA damage formed by bleomycin in vivo. Nucleic Acids Res. 24:885-889.
20. Ljungquist, S., T. Lindahl, and P. Howard-Flanders. 1976. Methyl methane sulfonate-sensitive mutant of Escherichia coli deficient in an endonuclease specific for apurinic sites in deoxyribonucleic acid. J. Bacteriol. 126:646-653.
21. Ma, M., and J. W. Eaton. 1992. Multicellular oxidant defense in unicellular organisms. Proc. Natl. Acad. Sci. USA 89:7924-7928.
22. Matsuyama, S., T. Tajima, and H. Tokuda. 1995. A novel periplasmic carrier protein involved in the sorting and transport of Escherichia coli lipoproteins destined for the outer membrane. EMBO J. 14:3365-3372.
23. Metcalf, H. E., D. W. Luchsinger, and W. C. Ray. 1994. Brucellosis, p. 9-39. In G. W. Beran and J. H. Steele (ed.), Handbook of zoonoses, 2nd ed., section A. CRC Press, Boca Raton, Fla.
24. Mol, C. D., C. F. Kuo, M. M. Thayer, R. P. Cunningham, and J. A. Tainer. 1995. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Nature 374:381-386.
25. Paulsen, I. T., R. Seshadri, K. E. Nelson, J. A. Eisen, J. F. Heidelberg, T. D. Read, R. J. Dodson, L. Umajani, L. M. Brinkac, M. J. Beanan, S. C. Daugherty, R. T. Deboy, A. S. Durkin, J. F. Kolonay, R. Madupu, W. C. Nelson, B. Ayodeji, M. Kraul, J. Shetty, J. Malek, S. E. Van Aken, S. Riedmuller, H. Tettelin, S. R. Gill, O. White, S. L. Salzberg, D. L. Hoover, L. E. Lindler, S. M. Halling, S. M. Boyle, and C. M. Fraser. 2002. The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Proc. Natl. Acad. Sci. USA 99:13148-13153.
26. Roop, R. M., II, B. H. Bellaire, M. W. Valderas, and J. A. Cardelli. 2005. Adaptation of the brucellae to their intracellular niche. Mol. Microbiol. 52:621-630.
27. Rosner, B. 2000. Fundamentals of biostatistics, 5th ed. Duxbury, Pacific Grove, Calif.
28. Sathiyaseelan, J., X. Jiang, and C. L. Baldwin. 2000. Growth of Brucella abortus in macrophages from resistant and susceptible mouse strains. Clin. Exp. Immunol. 121:289-294.
29. Shida, T., M. Noda, and J. Sekiguchi. 1996. Cleavage of single- and double-stranded DNAs containing an abasic residue by Escherichia coli exonuclease III (AP endonuclease IV). Nucleic Acids Res. 24:4572-4576.
30. Singh, R. J., N. Hogg, J. Joseph, E. Konorev, and B. Kalyanaraman. 1999. The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. Arch. Biochem. Biophys. 361:331-339.
31. Suvarnapunya, A. E., H A. Lagasse, and M. A. Stein. 2003. The role of DNA base excision repair in the pathogenesis of Salmonella enterica serovar Typhimurium. Mol. Microbiol. 48:549-559.
32. Tomasz, M., R. Lipman, D. Chowdary, J. Pawlak, G. L. Verdine, and K. Nakanishi. 1987. Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA. Science 235:1204-1208.
33. Vasquez-Torres, A., J. Jones-Carson, P. Mastroeni, H. Ischiropoulos, and F. C. Fang. 2000. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro. J. Exp. Med. 192:227-236.