Transgenic mice over-expressing endothelin-1 in testis transactivated by a Cre/loxP system showed decreased testicular capillary blood flow

Transgenic Research

Volumn 13, Issue 2, 2004, Pages 119-134

  Lo, Amy C Y ^a   Fung, Maggie K L ^a   Au, C L ^b   Chan, Theobald S K ^a   Sauer, Brian ^c   Chung, Stephen S M ^a   Chung, Sookja K ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Conditional; EF1 ; EIIA cre; Transgenic mice; Two tiered

Indexed keywords

BETA GALACTOSIDASE; CRE RECOMBINASE; ELONGATION FACTOR 1; ENDOTHELIN 1; INTEGRASE; MESSENGER RNA; VIRUS PROTEIN;

ANIMAL; ARTICLE; CAPILLARY; GENETICS; MALE; METABOLISM; MOUSE; PHYSIOLOGY; REPORTER GENE; TESTIS; TRANSGENIC MOUSE; ULTRASTRUCTURE; UPREGULATION; VASCULARIZATION;

ANIMALS; BETA-GALACTOSIDASE; CAPILLARIES; ENDOTHELIN-1; GENES, REPORTER; INTEGRASES; MALE; MICE; MICE, TRANSGENIC; PEPTIDE ELONGATION FACTOR 1; RNA, MESSENGER; TESTIS; UP-REGULATION; VIRAL PROTEINS;

ANIMALIA; ESCHERICHIA COLI; EUKARYOTA; MUS MUSCULUS; RODENTIA;

EID: 3242877050     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:TRAG.0000026072.01351.10     Document Type: Article

References (50)

1. Amann RP and Lambiase Jr JT (1969) The male rabbit. 3. Determination of daily sperm production by means of testicular homogenates. J Anim Sci 28: 369-374.
2. Au CL (1989) Measurement of rat testicular blood flow using a hydrogen gas clearance method. Proc Aust Soc Reprod Biol 21: 2.
3. 2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells. FASEB J 16: 697-705.
4. Bergh A, Collin O and Lissbrant E (2001) Effects of acute graded reductions in testicular blood flow on testicular morphology in the adult rat. Biol Reprod 64: 13-20.
5. Chan TS, Lin CX, Chan WY, Chung SS and Chung SK (1995) Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic development. Eur J Biochem 234: 819-826.
6. Collin O, Damber JE and Bergh A (1996) Effects of endothelin-1 on the rat testicular vasculature. J Androl 17: 360-366.
7. Conte D, Questino P, Fillo S, Nordio M, Isidori A and Romanelli F (1993) Endothelin stimulates testosterone secretion by rat Leydig cells. J Endocrinol 136: R1-R4.
8. Ergul A, Glassberg MK, Majercik MH and Puett D (1993) Endothelin-1 promotes steroidogenesis and stimulates protooncogene expression in transformed murine Leydig cells. Endocrinology 132: 598-603.
9. Ergun S, Harneit S, Paust HJ, Mukhopadhyay AK and Holstein AF (1998) Endothelin and endothelin receptors A and B in the human testis. Anat Embryol (Berl) 199: 207-214.
10. Fantoni G, Morris PL, Forti G, Vannelli GB, Orlando C, Barni T, Sestini R, Danza G and Maggi M (1993) Endothelin-1: a new autocrine/paracrine factor in rat testis. Am J Physiol 265: E267-E274.
11. Furuchi T, Masuko K, Nishimune Y, Obinata M and Matsui Y (1996) Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia. Development 122: 1703-1709.
12. Hammami MM, Haq A and AlSedairy S (1994) The level of endothelin-like immunoreactivity in seminal fluid correlates positively with semen volume and negatively with plasma gonadotrophin levels. Clin Endocrinol (Oxf) 40: 361-366.
13. Hanaoka K, Hayasaka M, Uetsuki T, Fujisawa-Sehara A and Nabeshima Y (1991) A stable cellular marker for the analysis of mouse chimeras: the bacterial chloramphenicol acetyltransferase gene driven by the human elongation factor 1 alpha promoter. Differentiation 48: 183-189.
14. Harneit S, Paust HJ, Mukhopadhyay AK and Ergun S (1997) Localization of endothelin-1 and endothelin-receptors A and B in human epididymis. Mol Hum Reprod 3: 579-584.
15. Hedger MP, Khatab S, Gonzales G and de Kretser DM (1995) Acute and short-term actions of serotonin administration on the pituitary-testicular axis in the adult rat. Reprod Fertil Dev 7: 1101-1109.
16. Hocher B, Thone-Reineke C, Rohmeiss P, Schmager F, Slowinski T, Burst V, Siegmund F, Quertermous T, Bauer C, Neumayer HH, Schleuning WD and Theuring F (1997) Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest 99: 1380-1389.
17. Hocher B, Schwarz A, Fagan KA, Thone-Reineke C, El-Hag K, Kusserow H, Elitok S, Bauer C, Neumayer HH, Rodman DM and Theuring F (2000) Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. Am J Respir Cell Mol Biol 23: 19-26.
18. Koopman P, Gubbay J, Vivian N, Goodfellow P and Lovell-Badge R (1991) Male development of chromosomally female mice transgenic for Sry. Nature 351: 117-121.
19. Korpelainen EI, Karkkainen MJ, Tenhunen A, Lakso M, Rauvala H, Vierula M, Parvinen M and Alitalo K (1998) Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF. J Cell Biol 143: 1705-1712.
20. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T, Cao WH, Kamada N, Jishage K, Ouchi Y, Azuma S, Toyoda Y, Ishikawa T, Kumada M and Yazaki Y (1994) Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 368: 703-710.
21. Lakso M, Sauer B, Mosinger Jr B, Lee EJ, Manning RW, Yu SH, Mulder KL and Westphal H (1992) Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci USA 89: 6232-6236.
22. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW and Westphal H (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci USA 93: 5860-5865.
23. Langford KG, Shai SY, Howard TE, Kovac MJ, Overbeek PA and Bernstein KE (1991) Transgenic mice demonstrate a testis specific promoter for angiotensin-converting enzyme. J Biol Chem 266: 15559-15562.
24. Langenstroer P, Tang R, Shapiro E, Divish B, Opgenorth T and Lepor H (1993) Endothelin-1 in the human prostate: tissue levels, source of production and isometric tension studies. J Urol 150: 495-499.
25. Maggi M, Barni T, Orlando C, Fantoni G, Finetti G, Vannelli GB, Mancina R, Gloria L, Bonaccorsi L, Yanagisawa M and Forti G (1995) Endothelin-1 and its receptors in human testis. J Androl 16: 213-224.
26. Melaine N, Ruffault A, Dejucq-Rainsford N and Jegou B (2003) Experimental inoculation of the adult rat testis with Sendai virus: effect on testicular morphology and leukocyte population. Hum Reprod 18: 1574-1579.
27. Nussdorfer GG, Rossi GP, Malendowicz LK and Mazzocchi G (1999) Autocrine-paracrine endothelin system in the physiology and pathology of steroid-secreting tissues. Pharmacol Rev 51: 403-438.
28. Orban PC, Chui D and Marth JD (1992) Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA 89: 6861-6865.
29. Peri A, Fantoni G, Granchi S, Vannelli GB, Barni T, Amerini S, Pupilli C, Barbagli G, Serio M, Maggi M and Forti G (1998) Endothelin-1 is synthesized and biologically active in human epididymis via a paracrine mode of action. Steroids 63: 294-298.
30. Romanelli F, Fillo S, Isidori A and Conte D (1997) Stimulatory action of endothelin-1 on rat Leydig cells: involvement of endothelin-A subtype receptor and phospholipase A2-arachidonate metabolism system. Life Sci 61: 557-566.
31. Sakaguchi H, Kozuka M, Hirose S, Ito T and Hagiwara H (1992) Properties and localization of endothelin-1-specific receptors in rat testicles. Am J Physiol 263: R15-R18.
32. Sakai K and Miyazaki J (1997) A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the ere transgene transmission. Biochem Biophys Res Commun 237: 318-324.
33. Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K and Sugishita Y (1996) Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart. Circulation 93: 1214-1222.
34. Sauer B (1993) Manipulation of transgenes by site-specific recombination: use of Cre recombinase. Methods Enzymol 225: 890-900.
35. Sauer B (1998) Inducible gene targeting in mice using the Cre/lox system. Methods 14: 381-392.
36. Sauer B and Henderson N (1988) The cyclization of linear DNA in Escherichia coli by site-specific recombination. Gene 70: 331-341.
37. Schwenk F, Baron U and Rajewsky K (1995) A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucl Acids Res 23: 5080-5081.
38. Shaper NL, Harduin-Lepers A and Shaper JH (1994) Male germ cell expression of murine beta 4-galactosyltransferase. A 796-base pair genomic region, containing two cAMP-responsive element (CRE)-like elements, mediates male germ cell-specific expression in transgenic mice. J Biol Chem 269: 25165-25171.
39. Shichiri M, Marumo F and Hirata Y (1998) Endothelin-B receptor-mediated suppression of endothelial apoptosis. J Cardiovasc Pharmacol 31: S138-S141.
40. Shindo T, Kurihara H, Maemura K, Kurihara Y, Ueda O, Suzuki H, Kuwaki T, Ju KH, Wang Y Ebihara A, Nishimatsu H, Moriyama N, Fukuda M, Akimoto Y, Hirano H, Morita H, Kumada M, Yazaki Y, Nagai R and Kimura K (2002) Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1. J Mol Med 80: 105-116.
41. Siegal ML and Hartl DL (2000) Application of Cre/loxP in Drosophila. Site-specific recombination and transgene coplacement. Meth Mol Biol 136: 487-495.
42. Stern JA, Lui RC, LaRegina MC, Herbold DR, Tolman KC and Johnson FE (1990) Long-term outcome following testicular ischemia in the rat. J Androl 11: 390-395.
43. Sternberg N and Hamilton D (1981) Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J Mol Biol 150: 467-486.
44. Tan SS, Williams EA and Tam PP (1993) X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo. Nat Genet 3: 170-174.
45. Tripiciano A, Filippini A, Giustiniani Q and Palombi F (1996) Direct visualization of rat peritubular myoid cell contraction in response to endothelin. Biol Reprod 55: 25-31.
46. Tripiciano A, Palombi F, Ziparo E and Filippini A (1997) Dual control of seminiferous tubule contractility mediated by ETA and ETB endothelin receptor subtypes. FASEB J 11: 276-286.
47. Tripiciano A, Peluso C, Morena AR, Palombi F, Stefanini M, Ziparo E, Yanagisawa M and Filippini A (1999) Cyclic expression of endothelin-converting enzyme-1 mediates the functional regulation of seminiferous tubule contraction. J Cell Biol 145: 1027-1038.
48. Wu-Wong JR, Chiou WJ, Dickinson R and Opgenorth TJ (1997) Endothelin attenuates apoptosis in human smooth muscle cells. Biochem J 328: 733-737.
49. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y Yazaki Y, Goto K and Masaki T (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415.
50. Zouki C, Baron C, Fournier A and Filep JG (1999) Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor. Br J Pharmacol 127: 969-979.