Catalytic-enantioselective methoxycarbonylation of 1,3-dichloroarenetricarbonyl-chromium(0) complexes: A desymmetrization approach to planar chirality

Synlett

Volumn , Issue 11, 2003, Pages 1595-1598

  Böttcher, Andreas ^a   Schmalz, Hans Günther ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Arene complexes; Asymmetric catalysis; Chromium; Kinetic resolution; Palladium

Indexed keywords

1,3 DICHLOROARENE; CHROMIUM DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC CATALYSIS; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CHEMICAL REACTION; CHIRALITY; DESYMMETRIZATION; ENANTIOMER; ENANTIOSELECTIVITY; KINETICS; METHOXYCARBONYLATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 3242814888     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-41417     Document Type: Article

References (26)

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19. 2 (16.2 mg, 0.025 mmol) were placed under argon in a flame-dried Schlenk flask equipped with a reflux condenser. Deoxygenated anhydrous methanol (3.3 mL) and triethylamine (1,7 mL) were added via a syringe and the reaction mixture was degassed and flushed with argon four times and finally flushed with CO. After stirring at 40 °C for 1 h the reaction mixture was cooled in an ice-bath, diluted with MTBE and filtered through a pad of silica. Upon concentration of the filtrate the received orange oil was subjected to column chromatography (silica, CyHex/MTBE = 8/1): 1b (10.3 mg, 7%), 2b (101.9 mg, 64%, orange oil) and 3b (39.2 mg, 23%, orange crystals).
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