ARTICLE;
CATALYSIS;
CATALYST;
CHEMICAL REACTION;
CRYSTAL STRUCTURE;
DRUG POTENCY;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
ENZYME BINDING;
HUMAN IMMUNODEFICIENCY VIRUS 1;
NONHUMAN;
X RAY CRYSTALLOGRAPHY;
CHEMISTRY;
CONFORMATION;
DRUG DESIGN;
ENZYMOLOGY;
SYNTHESIS;
HUMAN IMMUNODEFICIENCY VIRUS;
HUMAN IMMUNODEFICIENCY VIRUS 1;
ANTI-HIV AGENTS;
CATALYTIC DOMAIN;
DRUG DESIGN;
HIV INTEGRASE INHIBITORS;
HIV-1;
MOLECULAR CONFORMATION;
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
Hazuda D.J., Felock P., Witmer M., Wolfe A., Stillmock K., Grobler J.A., Espeseth A., Gabryelski L., Schleif W., Blau C., Miller M.D. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science. 287:2000;646-650
In vitro activity of a new HIV-1 integrase inhibitor in clinical development
Seattle
Yoshinaga, T.; Sato, A.; Fujishita, T.; Fujiwara, T. In vitro activity of a new HIV-1 integrase inhibitor in clinical development. 9th Conference on Retroviruses and Opportunistic Infections; Seattle, 2002
Neamati N., Turpin J.A., Winslow H.E., Christensen J.L., Williamson K., Orr A., Rice W.G., Pommier Y., Garofalo A., Brizzi A., Campiani G., Fiorini I., Nacci V. Thiazolothiazepine inhibitors of HIV-1 integrase. J. Med. Chem. 42:1999;3334-3341
Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators
Bergeron R.J., Wiegand J., Wollenweber M., McManis J.S., Algee S.E., Ratliff-Thompson K. Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators. J. Med. Chem. 39:1996;1575-1581
Conversion of amino hydroxyacids to oxazolidine-4-carboxylic acids, oxazolidine-5-carboxylic acids and tetrahydrooxazine-4-carboxylic acids
Wolfe S., Militello G., Ferrari C., Hasan S.K., Lee S.L. Conversion of amino hydroxyacids to oxazolidine-4-carboxylic acids, oxazolidine-5-carboxylic acids and tetrahydrooxazine-4-carboxylic acids. Tetrahedron Lett. 20:1979;3913-3916
Optically active 4-oxaproline derivatives: New useful chiral synthons derived from serine and threonine
Falorni M., Conti S., Giacomelli G., Cossu S., Soccolini F. Optically active 4-oxaproline derivatives: new useful chiral synthons derived from serine and threonine. Tetrahedron: Asymmetry. 6:1995;287-294
Synthesis of benzofuranones related to diazonamide via an intramolecular Pummerer reaction
Magnus P., Kreisberg J.D. Synthesis of benzofuranones related to diazonamide via an intramolecular Pummerer reaction. Tetrahedron Lett. 40:1999;451-454
The facile synthesis of macrocyclic lactones by the use of 2-chloro-3-methoxymethyl-1-methylpyridinium iodide
Narasaka K., Masui T., Mukaiyama T. The facile synthesis of macrocyclic lactones by the use of 2-chloro-3-methoxymethyl-1-methylpyridinium iodide. Chem. Lett. 1977;763-766
Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: Implication for binding to two metal ions on the active site of integrase
Long Y.Q., Jiang X.H., Dayam R., Sanchez T., Shoemaker R., Sei S., Neamati N. Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase. J. Med. Chem. 47:2004;2561-2573
Development and validation of a genetic algorithm for flexible docking
Jones G., Willett P., Glen R.C., Leach A.R., Taylor R. Development and validation of a genetic algorithm for flexible docking. J. Mol. Biol. 267:1997;727-748
A new test set for validating predictions of protein-ligand interaction
Nissink J.W., Murray C., Hartshorn M., Verdonk M.L., Cole J.C., Taylor R. A new test set for validating predictions of protein-ligand interaction. Proteins. 49:2002;457-471
