A comparative study of the hydrolysis pathways of substituted aryl phosphoramidate versus aryl thiophosphoramidate derivatives of stavudine

European Journal of Medicinal Chemistry

Volumn 39, Issue 8, 2004, Pages 665-683

  Venkatachalam, T K ^a   Yu, G ^a   Samuel, P ^a   Qazi, S ^a   Pendergrass, S ^a   Uckun, F M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

31P NMR; Activation energy; HPLC; Phosphoramides; Stavudine; Thiophosphoramides

Indexed keywords

ESTER; ESTERASE; FUNCTIONAL GROUP; METHYL GROUP; OXYGEN DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHORUS 31; STAVUDINE; SULFUR DERIVATIVE;

ARTICLE; COMPARATIVE STUDY; DRUG HYDROLYSIS; DRUG POTENCY; DRUG STRUCTURE; ENERGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION;

AMIDES; ANIMALS; CELLS, CULTURED; HUMANS; HYDROLYSIS; PHOSPHATES; PHOSPHORIC ACIDS; STAVUDINE; SWINE;

EID: 3242771413     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.04.002     Document Type: Article

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