The marine toxin dinophysistoxin-2 induces differential apoptotic death of rat cerebellar neurons and astrocytes

Toxicological Sciences

Volumn 80, Issue 1, 2004, Pages 74-82

  Pérez Gómez, Anabel ^a   García Rodríguez, Armando ^a   James, Kevin J ^b   Ferrero Gutierrez, Amaia ^a   Novelli, Antonello ^a   Fernández Sánchez, M Teresa ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b Munster Technological University   (Ireland)

Author keywords

Apoptosis; Cerebellar neurons; Diarrhetic shellfish poisoning; Dinophysistoxins; Glial cells; Neurotoxicity

Indexed keywords

DINOPHYSISTOXIN 2; DNA FRAGMENT; MARINE TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHROMATIN CONDENSATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXPERIMENTAL DESIGN; GLIA CELL; IN VITRO STUDY; IN VIVO STUDY; LONG TERM EXPOSURE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEURITE; NEUROTOXICITY; NONHUMAN; PROTEIN SYNTHESIS; RAT;

ANIMALS; APOPTOSIS; ASTROCYTES; BIVALVIA; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; DNA FRAGMENTATION; ELECTROPHORESIS, AGAR GEL; MARINE TOXINS; NEURITES; NEURONS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; PYRANS; RATS;

ALGAE;

EID: 3242768423     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh139     Document Type: Article

References (39)

1. Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C. E., Frautschy, S., Griffin, W. S., Hampel, H., Hull, M., Landreth, G., Lue, L., Mrak, R., Mackenzie, I. R., McGeer, P. L., O'Banion, M. K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., Van Muiswinkel, F. L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G., and Wyss-Coray, T. (2000). Inflamation and Alzheimer's disease. Neurobiol. Aging 21, 383-421.
2. Behl, C., Davis, J. B., Lesley, R., and Schubert, D. (1994). Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77, 817-827.
3. Bennecib, M., Gong, C.-X., Grundke-Iqbal, I., and Iqbal, K. (2000). Role of protein phosphatase-2A and -1 in the regulation of GSK-3. cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS Lett. 485, 87-93.
4. L. Leukemia 11, 940-944.
5. Bialojan, C., and Takai, A. (1988). Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256, 283-290.
6. Blanco, J., Fernández, M., Marino, J., Reguera, B., Míguez, A., Maneiro, J., Cacho, E., and Martínez, A. (1995 . From Dinophysis spp. toxicity to DSP outbrakes: A preliminary model of toxin accumulation in mussels. In Harmful Marine Algal Blooms (P. Lassus, G. Arzul, E. Erard, P. Gentien, and C. Marcaillou, Eds.), pp. 777-782. Lavoisier Science Publishers, Paris.
7. Carmody, E. P., James, K. J., and Kelli, S. S., (1996). Dinophysistoxin-2: The predominant diarrhetic shellfish toxin in Ireland. Toxicon 34, 351-359.
8. D'Mello, S. R., Galli, C., Ciotti, T., and Calissano, P. (1993). Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. U.S.A. 90, 10989-10993.
9. Ekdahl, C. T., Claasen, J.-H., Bonde, S., and Lindvall, O. (2003). Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. U.S.A. 100, 13632-13637.
10. Fernández, M. L., Míguez, A., Moroño, A., Cacho, E., Martínez, A., and Blanco, J. (1998). Detoxification of low polarity toxins (DTX-3) from mussels Mytilus Galloprovincialis in Spain. In Harmful Algae (B. Reguera, J. Blanco, M. L. Fernández, and T. Wyatt, Eds.), pp. 449-452. Xunta de Galicia and IOC of UNESCO, Vigo, Spain.
11. Fernández, M. T., Zitko, V., Gascón, S., and Novelli, A. (1991). The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons. Life Sci. 49, PL157-PL162.
12. Fernández, M. T., Zitko, V., Gascón, S., Torreblanca, A., and Novelli, A. (1993). Neurotoxic effect of okadaic acid, a seafood-related toxin, on cultured cerebellar neurons. Ann. N.Y. Acad. Sci. 679, 260-269.
13. Fernández-Sánchez, M. T., and Novelli, A. (1993). Basic fibroblast growth factor protects cerebellar neurons in primary culture from NMDA and non-NMDA receptor mediated neurotoxicity. FEBS Lett. 335, 124-131.
14. Fernández-Sánchez, M. T., García-Rodríguez, A., Díaz-Trelles, R., and Novelli, A. (1996). Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis. FEBS Lett. 398, 106-112.
15. Fernández-Sánchez, M. T., Díaz-Trelles, R., Groppetti, A., Manfredi, B., Brini, A. T., Biella, G., Sotgiu, M. L., and Novelli, A. (2001). Novel effect of nefopam preventing cGMP increase, oxygen radical formation and neuronal death induced by veratridine. Neuropharmacology 41, 935-942.
16. García-Rodríguez, A., Fernández-Sánchez, M. T., Reyero, M. I., Franco, J. M., Haya, K., Martín, J., Zitko, V., Salgado, C., Arévalo, F., Bermúdez, M., Fernández, M. L., Míguez, A., and Novelli, A. (1998). Detection of PSP, ASP and DSP toxins by neuronal bioassay: Comparison with HPLC and mouse bioassay. In Harmful Algae (B. Reguera, J. Blanco, M. L. Ferná ndez, and T. Wyatt, Eds.), pp. 554-557. Xunta de Galicia and IOC of UNESCO, Vigo, Spain.
17. Gong, C. -X., Singh, T.J., Grundke-Iqbal, I., and Iqbal, K. (1993). Phosphoprotein phosphatase activities in Alzheimer disease brain. J. Neurochem. 61, 921-927.
18. Gong, C.-X, Shaikh, S., Wang, J.-Z., Zaidi, T., Grundke-Iqbal, I., and Iqbal, K. (1995). Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain. J. Neurochem. 65, 732-738.
19. James, K. J., Bishop, A. G., Brendan, M. H., Roden, C., Sherlock, I. R., Twohig, M., Draisci, R., Giannetti, L., and Lucentini, L. (1999). Efficient isolation of the rare diarrhoeic shellfish toxin, dinophysistoxin-2, from marine phytoplankton. Toxicon 37, 343-357.
20. Lee, J. S., Igarashi, T., Fraga, S., Dahl, E., Hovgaard, P. Y., and Yasumoto, T. (1989). Determination of diarrhetic shellfish toxins in various dinoflagellate species. J. Appl. Phycol. 1, 147-152.
21. Lipsky, R. H., Xu, K., Zhu, D., Kelly, C., Terhakopian, A., Novelli, A., and Marini, A. M. (2001). Nuclear factor kB is a critical determinant in N-methyl-D-aspartate receptor-mediated neuroprotection. J. Neurochem. 78, 254-264.
22. Martin-Romero, F. J., Santiago-Josefat, B., Correa-Bordes, J., Gutierrez-Merino, C., and Fernández-Salguero, P. (2000). Potassium-induced apoptosis in rat cerebellar granule cells involves cell-cycle blockade at the G1/S transition. J. Mol. Neurosci. 15, 155-165.
23. McMahon, T., Silke, J., Nixon, E., Taaffe, B., Nolan, A., McGovern, E., and Doyle, J. (1996). Seasonal variation in diarrhetic shellfish toxins in mussels from the Southwest coast of Ireland in 1994. In Irish Marine Science 95 (B. F. Keegan and R. O'Connor, Eds.), pp. 417-432. Galway University Press, Galway.
24. Novelli, A., Nicoletti, F., Wroblewski, J. T, Alho, H., Costa, E., and Guidotti, A. (1987). Excitatory aminoacid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells. J. Neurosci. 7, 40-47.
25. Novelli, A., Reilly, J. A., Lypsko, P. G., Henneberry, R. C. (1988). Glutamate becomes neurotoxic via the NMDA receptor when intracellular energy levels are reduced. Brain Res. 451, 205-212.
26. Novelli, A., Kispert, J., Fernández-Sánchez, M. T., Torreblanca, A., and Zitko, V. (1992). Domoic acid-containing toxic mussels produce neurotoxicity in neuronal cultures through a synergism between excitatory amino acids. Brain Res. 577, 41-48.
27. Padmanabhan, J., Park, D. S., Greene, L. A., and Shelanski, M. L. (1999). Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J. Neurosci. 19, 8747-8756.
28. Park, D. S., Farinelli, S. E., and Greene, L. A. (1996). Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J. Biol. Chem. 271, 8161-8169.
29. Pavela-Vrancic, M., Mestrovic, V. V., Marasovic, I. I., Gillman, M., Furey, A., and James K. J. (2002). DSP toxin profile in the coastal waters of the central Adriatic Sea. Toxicon 40, 1601-1607.
30. Quilliam, M. A., Gilgan, M. W., Pleasance, S., deFreitas, A. S. W., Douglas, D., Fritz, L., Hu, T., Marr, J. C., Smyth, C., and Wright, J. L. C. (1993). Confirmation of an incident of diarrhetic shellfish poisoning in eastern Canada. In Toxic Phytoplancton Blooms in the Sea (T. J. Smayda and Y. Shimizu, Eds.), pp. 547-552. Elsevier, Amsterdam.
31. Raff, M. C. (1992). Social controls on cell survival and cell death. Nature 356, 397-400.
32. Sheikh, M. S., García, M., Zhan, Q., Liu, Y., and Fornace, A. J. (1996). Cell-cycle independent regulation of p21Wafl/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells. Cell Growth Differ. 7, 1599-1607.
33. Suárez-Fernández, M. B., Soldado, A. B., Sanz-Medel, A., Vega, J. A., Novelli, A., and Fernández-Sánchez, M. T. (1999). Aluminium-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death. Brain Res. 835, 125-136.
34. Vale, P., and Sampayo, M. A. (1996). DTX-2 in Portuguese shellfish. In Harmful and Toxic Algal Blooms (T. Yasumoto, Y. Oshima, and Y. Fukuyo, Eds.), pp. 539-542. International Commission of UNESCO, Sendai.
35. Vale, P., and Sampayo, M. A. (2000). Dinophysistoxin-2: A rare diarrhoeic toxin associated with Dinophysis acuta. Toxicon 38, 1599-1606.
36. Wyllie, A. H. (1980). Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555-556.
37. Yan, Y., Shay, J. W., Wright, W. E., and Mumby, M. C. (1997) Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J. Biol. Chem. 272, 15220-15226.
38. Yasumoto, T., Murata, M., Oshima, Y., Matsumoto, G. K., and Clardy, J. (1984). Diarrhetic shellfish poisoning. In Seafood Toxins (E. P. Ragelis, Ed.), pp. 214-217. AOAC International, Washington, DC.
39. Yasumoto, T., Oshima, Y., and Yamaguchi, M. (1979). Occurrence of a new type shellfish poisoning in Japan and chemical properties of the toxin. In Toxic Dinoflagellates Blooms (D. L. Taylor and H. H. Seliger, Eds.), pp. 495-502. Elsevier, Amsterdam.