Activators of PPARγ antagonize protection of cardiac myocytes by endothelin-1

Biochemical and Biophysical Research Communications

Volumn 321, Issue 2, 2004, Pages 345-349

  Ehara, Natsuhiko ^a   Hasegawa, Koji ^b   Ono, Koh ^b   Kawamura, Teruhisa ^b   Iwai Kanai, Eri ^a   Morimoto, Tatsuya ^a   Akao, Masaharu ^a   Adachi, Souichi ^a   Kita, Toru ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION KYOTO MEDICAL CENTER   (Japan)

Author keywords

Apoptosis; Bcl 2; Cardiac myocyte; ET 1; NFATc; PPAR

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; APOPTOSIS INHIBITOR; ENDOTHELIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PROTEIN BCL 2; TRANSCRIPTION FACTOR NFAT; TROGLITAZONE; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CARDIOTONIC AGENT; CELL RECEPTOR; CHROMAN DERIVATIVE; DNA; DNA BINDING PROTEIN; DRUG DERIVATIVE; NUCLEAR PROTEIN; PROSTAGLANDIN D2; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; ANIMAL; APOPTOSIS; CELL CULTURE; CYTOLOGY; DRUG POTENTIATION; GENETICS; METABOLISM;

ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CELLS, CULTURED; CHROMANS; DNA; DNA-BINDING PROTEINS; ENDOTHELIN-1; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROSTAGLANDIN D2; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS;

EID: 3242765294     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.06.147     Document Type: Article

References (21)

1. M. Packer The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure J. Am. Coll. Cardiol. 20 1992 248 254
2. J.R. Wu-Wong, W.J. Chiou, R. Dickinson and T.J. Opgenorth Endothelin attenuates apoptosis in human smooth muscle cells Biochem. J. 328 Pt. 3 1997 733 737
3. M. Shichiri, J.M. Sedivy, F. Marumo and Y. Hirata Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis Mol. Endocrinol. 12 1998 172 180
4. M. Araki, K. Hasegawa, E. Iwai-Kanai, M. Fujita, T. Sawamura, T. Kakita, H. Wada, T. Morimoto and S. Sasayama Endothelin-1 as a protective factor against β-adrenergic agonist-induced apoptosis in cardiac myocytes J. Am. Coll. Cardiol. 36 2000 1411 1418
5. R.M. Touyz, J. Fareh, G. Thibault, B. Tolloczko, R. Lariviere and E.L. Schiffrin Modulation of Ca2+ transients in neonatal and adult rat cardiomyocytes by angiotensin II and endothelin-1 Am. J. Physiol. 270 1996 H857 868
6. A. Rao, C. Luo and P.G. Hogan Transcription factors of the NFAT family: regulation and function Annu. Rev. Immunol. 15 1997 707 747
7. T. Kakita, K. Hasegawa, E. Iwai-Kanai, S. Adachi, T. Morimoto, H. Wada, T. Kawamura, T. Yanazume and S. Sasayama Calcineurin pathway is required for endothelin-1-mediated protection against oxidant stress-induced apoptosis in cardiac myocytes Circ. Res. 88 2001 1239 1246
8. D. Bishop-Bailey Peroxisome proliferator-activated receptors in the cardiovascular system Br. J. Pharmacol. 129 2000 823 834
9. E.D. Rosen and B.M. Spiegelman PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth J. Biol. Chem. 276 2001 37731 37734
10. X.Y. Yang, L.H. Wang, T. Chen, D.R. Hodge, J.H. Resau, L. DaSilva and W.L. Farrar Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARIγ) agonists. PPARγ co-association with transcription factor NFAT J. Biol. Chem. 275 2000 4541 4544
11. R.B. Clark, D. Bishop-Bailey, T. Estrada-Hernandez, T. Hla, L. Puddington and S.J. Padula The nuclear receptor PPARγ and immunoregulation: PPARγ mediates inhibition of helper T cell responses J. Immunol. 164 2000 1364 1371
12. E. Iwai-Kanai, K. Hasegawa, M. Araki, T. Kakita, T. Morimoto and S. Sasayama α- and β-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes Circulation 100 1999 305 311
13. T. Kakita, K. Hasegawa, T. Morimoto, S. Kaburagi, H. Wada and S. Sasayama p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene J. Biol. Chem. 274 1999 34096 34102
14. T. Morimoto, K. Hasegawa, S. Kaburagi, T. Kakita, H. Masutani, R.N. Kitsis, A. Matsumori and S. Sasayama GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the β-myosin heavy chain gene in cardiac myocytes J. Biol. Chem. 274 1999 12811 12818
15. T. Morimoto, K. Hasegawa, S. Kaburagi, T. Kakita, H. Wada, T. Yanazume and S. Sasayama Phosphorylation of GATA-4 is involved in α1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes J. Biol. Chem. 275 2000 13721 13726
16. R. Aikawa, I. Komuro, T. Yamazaki, Y. Zou, S. Kudoh, M. Tanaka, I. Shiojima, Y. Hiroi and Y. Yazaki Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats J. Clin. Invest 100 1997 1813 1821
17. D. Kumar and B.I. Jugdutt Apoptosis and oxidants in the heart J. Lab. Clin. Med. 142 2003 288 297
18. T. Kawamura, K. Ono, T. Morimoto, M. Akao, E. Iwai-Kanai, H. Wada, N. Sowa, T. Kita and K. Hasegawa Endothelin-1-dependent NFATc signaling associates with transcriptional coactivator p300 in the activation of the bcl-2 promoter in cardiac myocytes Circ. Res. 94 2004 1492 1499
19. S. Mudaliar and R.R. Henry New oral therapies for type 2 diabetes mellitus: The glitazones or insulin sensitizers Annu. Rev. Med. 52 2001 239 257
20. K. Yamamoto, R. Ohki, R.T. Lee, U. Ikeda and K. Shimada Peroxisome proliferator-activated receptor γ activators inhibit cardiac hypertrophy in cardiac myocytes Circulation 104 2001 1670 1675
21. M. Asakawa, H. Takano, T. Nagai, H. Uozumi, H. Hasegawa, N. Kubota, T. Saito, Y. Masuda, T. Kadowaki and I. Komuro Peroxisome proliferator-activated receptor γ plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo Circulation 105 2002 1240 1246