The heart and circulation in severe sepsis

British Journal of Anaesthesia

Volumn 93, Issue 1, 2004, Pages 114-120

  Young, J Duncan ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Blood, circulation; Blood, pressors; Blood, sepsis; Complications, septic shock; Complications, septicaemia

Indexed keywords

ACTIVATED PROTEIN C; ADRENALIN; ANTIBIOTIC AGENT; DROTRECOGIN; GAMMA INTERFERON; HYPERTENSIVE AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INFUSION FLUID; INOTROPIC AGENT; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; NORADRENALIN; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASOPRESSIN;

BLEEDING; CARDIOVASCULAR FUNCTION; CAUSE OF DEATH; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; CRITICAL ILLNESS; DISEASE CONTROL; DISEASE SEVERITY; DRUG FATALITY; DRUG MECHANISM; HEALTH CARE COST; HEART DISEASE; HEMODYNAMICS; HUMAN; INFLAMMATION; OXYGEN CONSUMPTION; PATIENT MONITORING; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPTIC SHOCK; SURGICAL DRAINAGE; VASODILATATION;

EID: 3242763845     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeh171     Document Type: Article

References (67)

1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864-74
2. Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine. Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Crit Care Med 1999; 00: 639-60
3. Alia I, Esteban A, Gordo F, et al. A randomized and controlled trial of the effect of treatment aimed at maximizing oxygen delivery in patients with severe sepsis or septic shock. Chest 1999; 115: 453-61
4. Arons MM, Wheeler AP, Bernard GR, et al. Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med 1999; 27: 699-707
5. Avontuur JA, Boomsma F, van den Meiracker AH, de Jong FH, Bruining HA. Endothelin-I and blood pressure after inhibition of nitric oxide synthesis in human septic shock. Circulation 1999; 99: 271-5
6. Bakker J, Grover R, McLuckie A, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med 2004; 32: 1-12
7. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709
8. Bone RC. Gram-negative sepsis. Background, clinical features, and intervention. Chest 1991; 100: 802-8
9. Bone RC. Let's agree on terminology: definitions of sepsis. Crit Care Med 1991; 19: 973-6
10. Boveris A, Alvarez S, Navarro A. The role of mitochondrial nitric oxide synthase in inflammation and septic shock. Free Radic Biol Med 2002; 33: 1186-93
11. Brealey D, Brand M, Hargreaves I, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360: 219-23
12. Buga GM, Griscavage JM, Rogers NE, Ignarro LJ. Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res 1993; 73: 808-12
13. Calvin JE, Driedger AA, Sibbald WJ. An assessment of myocardial function in human sepsis utilizing ECG gated cardiac scintigraphy. Chest 1981; 80: 579-86
14. Cunnion RE, Schaer GL, Parker MM, Natanson C, Parrillo JE. The coronary circulation in human septic shock. Circulation 1986; 73: 637-44
15. Ellrodt AG, Riedinger MS, Kimchi A, et al. Left ventricular performance in septic shock: reversible segmental and global abnormalities. Am Heart J 1985; 110: 402-9
16. Evans T, Carpenter A, Kinderman H, Cohen J. Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock 1993; 41: 77-81
17. Gattinoni L, Brazzi L, Pelosi P, et al. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 1995; 333: 1025-32
18. Gomez Jimenez J, Salgado A, Mourelle M, et al. L-arginine: nitric oxide pathway in endotoxemia and human septic shock. Crit Care Med 1995; 23: 253-8
19. Halushka PV, Reines HD, Barrow SE, et al. Elevated plasma 6-keto-prostaglandin F1 alpha in patients in septic shock. Crit Care Med 1985; 13: 451-3
20. Haupt MT, Jastremski MS, Clemmer TP, Metz CA, Goris GB. Effect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group. Crit Care Med 1991; 19: 1339-47
21. Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994; 330: 1717-22
22. Horvath I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, Barnes PJ. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-I in airway macrophages in asthma: a new marker of oxidative stress. Thorax 1998; 53: 668-72
23. Hussein Z, Beerahee M, Grover R, et al. Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Clin Pharmacol Ther 1999; 65: 1-9
24. Jha P, Jacobs H, Bose D, et al. Effects of E. coli sepsis and myocardial depressant factor on interval-force relations in dog ventricle. Am J Physiol 1993; 264: H1402-10
25. Kumar A, Thota V, Dee L, Olson J, Uretz E, Parrillo JE. Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med 1996; 183: 949-58
26. Landry DW, Levin HR, Gallant EM, et al. Vasopressin pressor hypersensitivity in vasodilatory septic shock. Crit Care Med 1997; 25: 1279-82
27. Laubach VE, Shesely EG, Smithies O, Sherman PA. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharicle-induced death. Proc Natl Acad Sci USA 1995; 92: 10 688-92
28. Leclerc F, Walter-Nicolet E, Leteurtre S, et al. Admission plasma vasopressin levels in children with meningococcal septic shock. Intensive Care Med 2003; 29: 1339-44
29. MacLean MD, Mulligan WG, McLean APH, Duff JH. Patterns of septic shock in man - a detailed study of 56 patients. Ann Surg 1967; 166: 543-62
30. MacMicking JD, Nathan C, Hom G, et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995; 81: 641-50
31. Martich GD, Parker MM, Cunnion RE, Suffredini AF. Effects of ibuprofen and pentoxifylline on the cardiovascular response of normal humans to endotoxin. J Appl Physiol 1992; 73: 925-31
32. Meyer J, Lentz CW, Stothert JC, Jr, Traber LD, Herndon DN, Traber DL. Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia. Crit Care Med 1994; 22: 306-12
33. Michalek SM, Moore RN, McGhee JR, Rosenstreich DL, Mergenhagen SE. The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin. J Infect Dis 1980; 141: 55-63
34. Mitaka C, Hirata Y, Makita K, Nagura T, Tsunoda Y, Amaha K. Endothelin-1 and atrial natriuretic peptide in septic shock. Am Heart J 1993; 126: 466-8
35. Nakae H, Endo S, Inada K, Takakuwa. T, Kasai T, Yoshida M. Relationship between thromboxane B2 and 6-keto-prostaglandin F1 alpha in sepsis. Res Commun Chem Pathol Pharmacol 1994; 83: 297-302
36. Nakae H, Endo S, Inada K, Watanabe M, Baba N, Yoshida M. Relationship between leukotriene B4 and prostaglandin 12 in patients with sepsis. Res Commun Mol Pathol Pharmacol 1994; 86: 37-42
37. Ochoa J, Udekwu A, Billiar T, et al. Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991; 214: 621-6
38. Oettinger W, Berger D, Beger HG. The clinical significance of prostaglandins and thromboxane as mediators of septic shock. Klin Wochensch 1987; 65: 61-8
39. Oettinger WK, Walter GO, Jensen UM, Beyer A, Peskar A. Endogenous prostaglandin F2 alpha in the hyperdynamic state of severe sepsis in man. Br J Surg 1983; 70: 237-9
40. Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003; 31: 2332-8
41. Parker MM, Shelhamer JH, Bacharach SL, et al. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984; 100: 483-90
42. Pathan N, Sandiford C, Harding SE, Levin M. Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med 2002; 30: 2191-8
43. Pittet JF, Morel DR, Hemsen A, et al. Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann Surg 1991; 213: 261-4
44. Reade MC, Young JD. Of mice and men (and rats): implications of species and stimulus differences for the interpretation of studies of nitric oxide in sepsis. Br J Anaesth 2003; 90: 115-18
45. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368-77
46. Romberg E, Pässler H, Bruhns C, Müller W. Untersuchungen über die allgemeine Pathologie and Therapie der Kreislaufstörung bie acuten Infectionskrankheiten. Arch Klin Med 1899; 64: 652-714
47. Scharte M, Bone HG, Van Aken H, Meyer J. Increased carbon monoxide in exhaled air of critically ill patients. Biochem Biophys Res Comm 2000; 267: 423-6
48. Schoedon G, Schneemann M, Walter R, Blau N, Hofer S, Schaffner A. Nitric oxide and infection: another view. Clin Infect Dis 1995; 21 (Suppl. 2): S152-7
49. Sharshar T, Blanchard A, Paillard M, Raphael JC, Gajdos P, Annane D. Circulating vasopressin levels in septic shock. Crit Care Med 2003; 31: 1752-8
50. Sharshar T, Carlier R, Blanchard A, et al. Depletion of neurohypophyseal content of vasopressin in septic shock. Crit Care Med 2002; 30: 497-500
51. Short BL, Gardiner M, Walker RI, Jones SR, Fletcher JR. Indomethacin improves survival in gram-negative sepsis. Adv Shock Res 1981; 6: 27-36
52. Slebos DJ, Ryter SW, Choi AM. Herne oxygenase-1 and carbon monoxide in pulmonary medicine. Respir Res 2003; 4: 7
53. Takakuwa T, Endo S, Nakae H, et al. Plasma levels of TNF-alpha, endothelin-1 and thrombomodulin in patients with sepsis. Res Commun Chem Pathol Pharmacol 1994; 84: 261-9
54. Tschaikowsky K, Sagner S, Lehnert N, Kaul M, Ritter J. Endothelin in septic patients: effects on cardiovascular and renal function and its relationship to proinflammatory cytokines. Crit Care Med 2000; 28: 1854-60
55. Tsuneyoshi I, Kanmura Y, Yoshimura N. Nitric oxide as a mediator of reduced arterial responsiveness in septic patients. Crit Care Med 1996; 24: 1083-6
56. Tsuneyoshi I, Yamada H, Kakihana Y, Nakamura M, Nakano Y, Boyle WA, 3rd. Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Crit Care Med 2001; 29: 487-93
57. Tuchschmidt J, Fried J, Astiz M, Rackow E. Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest 1992; 102: 216-20
58. vanHaren FM, Rozendaal FW, van der Hoeven JG. The effect of vasopressin on gastric perfusion in catecholamine-dependent patients in septic shock. Chest 2003; 124: 2256-60
59. Voerman HJ, Stehouwer CD, van Kamp GJ, Strack van Schijndel RJ, Groeneveld AB, Thijs LG. Plasma endothelin levels are increased during septic shock. Crit Care Med 1992; 20: 1097-101
60. Waisbren BA. Bacteremia due to Gram negative bacilli other than salmonella. Arch Intern Med 1951; 88: 467-88
61. Watson D, Grover R, Anzueto A, et al. Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med 2004; 32: 13-20
62. Weisel RD, Vito L, Dennis RC, Valeri CR, Hechtman HB. Myocardial depression during sepsis. Am J Surg 1977; 133: 512-21
63. Weitzberg E, Lundberg JM, Rudehill A. Elevated plasma levels of endothelin in patients with sepsis syndrome. Circ Shock 1991; 33: 222-7
64. Wilson MF, Brackett DJ, Hinshaw LB, Tompkins P, Archer LT, Benjamin BA. Vasopressin release during sepsis and septic shock in baboons and dogs. Surg Gynecol Obstet 1981; 153: 869-72
65. Yasuda H, Yamaya M, Yanai M, Ohrui T, Sasaki H. Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases. Thorax 2002; 57: 779-83
66. Young JD, Cameron EM. Dynamics of skin blood flow in human sepsis. Intensive Care Med 1995; 21: 669-74
67. Zegdi R, Caid R, Van De Louw A, et al. Exhaled carbon monoxide in mechanically ventilated critically ill patients: influence of inspired oxygen fraction. Intensive Care Med 2000; 26: 1228-31