Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1

Biochemical Journal

Volumn 381, Issue 2, 2004, Pages 405-412

  Denton, Helen ^a   McGregor, Joanne C ^a   Coombs, Graham H ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Antimonial; Chemotherapy; Glutathione S transferase; Leishmania; Parasite; Thiol dependent reductase

Indexed keywords

CHEMOTHERAPY; DRUG DOSAGE; ENZYMES; MONOMERS;

PARASITES; TRIMERS;

BIOCHEMISTRY;

ANTILEISHMANIAL AGENT; ANTIMONY; ARSENATE SODIUM; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ISOENZYME; MEGLUMINE ANTIMONATE; MONOMER; MONOMETHYLARSENATE; STIBOGLUCONATE SODIUM; THIOL DEPENDENT REDUCTASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ANALYSIS; LEISHMANIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DOMAIN; REDUCTION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIMONY; ANTIMONY SODIUM GLUCONATE; ANTIPROTOZOAL AGENTS; ARSENIC; CLONING, MOLECULAR; GLUTATHIONE TRANSFERASE; HUMANS; LEISHMANIA MAJOR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

ANIMALIA; MAMMALIA; PROTOZOA;

EID: 3242748862     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040283     Document Type: Article

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