Erythropoietin production can be enhanced by normobaric oxygen breathing in healthy humans

Undersea and Hyperbaric Medicine

Volumn 31, Issue 1, 2004, Pages 53-57

  Balestra, C ^a,b,d   Germonpre P ^a,c   Poortmans, J ^a,b   Marroni, A ^a   Schiettecatte, J ^e   Collard, J F ^a,c   Snoeck, T ^a,b,d  

^a DAN Europe Research Division   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c QUEEN ASTRID MILITARY HOSPITAL   (Belgium)

^d Haute Ecole Bruxelles Brabant   (Belgium)

^e UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; OXYGEN;

ADULT; ANALYSIS OF VARIANCE; ANOXIA; ARTICLE; BIOSYNTHESIS; BLOOD; BREATHING; CIRCADIAN RHYTHM; FEMALE; HEMATOCRIT; HUMAN; MALE; MIDDLE AGED; TIME;

ADULT; ANALYSIS OF VARIANCE; ANOXIA; CIRCADIAN RHYTHM; ERYTHROPOIETIN; FEMALE; HEMATOCRIT; HUMANS; MALE; MIDDLE AGED; OXYGEN; RESPIRATION; TIME FACTORS;

EID: 3242741326     PISSN: 10662936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (24)

1. Jacobson L, et al. Role of the kidneys in erythropoiesis. Nature Lond., 1957. 179: p. 633-634.
2. Clause T, et al. Erythropoietin response to hypobaric hypoxia, normobaric hypoxia, and hypocapnic normoxia in normal human. Eur J Appl Physiol 1996; 74:475-480.
3. Bernaudin M, et al. Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 2000; 30(3):271-278.
4. Zhu H, Jackson T, and Bunn HF. Detecting and responding to hypoxia. Nephrol Dial Transplant 2002; 17 Suppl 1:3-7.
5. Gonzalez C, et al. Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir Physiolo Neurobiol 2002; 132(1):17-41.
6. Koury ST, et al. Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. Blood 1989; 74(2):645-651.
7. Ratcliffe PJ, et al. Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection. J Exp Med 1990; 172(2):657-660.
8. Knaupp W, et al. Erythropoietin response to acute normobaric hypoxia in humans. J Appl Physiol 1992; 73(3):837-840.
9. Eckardt KU, Kurtz A, and Bauer C. Regulation of erythropoietin production is related to proximal tubular function. Am J Physiol 1989; 256(5 Pt 2):F942-F947.
10. Roberts D, et al. Plasma-volume contraction and exercise-induced hypoxaemia modulate erythropoietin production in healthy humans. Clin Sci (Lond) 2000; 98(1):39-45.
11. Roberts D and Smith DJ. Erythropoietin does not demonstrate circadian rhythm in healthy men. J Appl Physiol 1996; 80(3):847-851.
12. Klausen T, et al. Diurnal variations of serum erythropoietin at sea level and altitude. Eur J Appl Physiol Occup Physiol 1996; 72(4):297-302.
13. Rodriguez FA, et al. Intermittent hypobaric hypoxia stimulates erythropoiesis and improves aerobic capacity. Med Sci Sports Exerc 1999; 31(2):264-268.
14. Hankins TC, et al. Test and evaluation of exercise-enhanced preoxygenation in U-2 operations. Aviat Space Environ Med 2000; 71(8):822-826.
15. Webb JT and Pilmanis AA. Preoxygenation time versus decompression sickness incidence. Safe J 1999; 29(2):75-78.
16. Allen TH, Maio DA, and Bancroft RW. Body fat, denitrogenation and decompression sickness in men exercising after abrupt exposure to altitude. Aerosp Med 1971; 42(5):518-524.
17. Schuster SJ, et al. Physiologic regulation and tissue localization of renal erythropoietin messenger RNA. Blood 1987; 70(1):316-318.
18. Celik M, et al. Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci USA 2002; 99(4):2258-2263.
19. Cerami A, et al. Neuroprotective properties of epoetin alfa. Nephrol Dial Transplant 2002; 17:8-12.
20. Dawson TM. Preconditioning-mediated neuroprotection through erythropoietin? Lancet 2002; 359(9301):96-97.
21. Junk AK, et al. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci USA 2002.
22. Wen TC, et al. Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression. J Neurosci Res 2002; 67(6):795-803.
23. Linman JW and Pierre RV. Studies on the erythropoietic effects of hyperbaric hyperoxia. Ann N Y Acad Sci 1968; 149(1):25-33.
24. Necas E and Neuwirt J. Lack of erythropoietin in plasma of anemic rats exposed to hyperbaric oxygen. Life Sci 1969; 8(22):1221-1228.