Intermittent hypobaric hypoxia stimulates erythropoiesis and improves aerobic capacity

Medicine and Science in Sports and Exercise

Volumn 31, Issue 2, 1999, Pages 264-268

  Rodríguez, Ferran A ^a   Casas, Héctor ^b   Casas, Mireia ^b   Pagés, Teresa ^b   Rama, Ramón ^b   Ricart, Antoni ^b   Ventura, Josep L ^b   Ibáñez, Jordi ^b   Viscor, Ginés ^b  

^a National Institute of Physical Education of Catalonia   (Spain)

^b NONE

Author keywords

Acclimation; Altitude; Endurance; Hematopoiesis; Hypobaric chamber

Indexed keywords

ADULT; ALTITUDE ACCLIMATIZATION; ARTICLE; BICYCLE ERGOMETRY; BLOOD RHEOLOGY; ENDURANCE; ERYTHROPOIESIS; EXERCISE TEST; FEMALE; GAS ANALYSIS; HEMATOLOGICAL PARAMETERS; HEMATOPOIESIS; HUMAN; HUMAN EXPERIMENT; HYPOBARISM; HYPOXIA; MALE; NORMAL HUMAN;

EID: 0344959404     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-199902000-00010     Document Type: Article

References (25)

1. BROOKS, G. A., G. E. BUTTERFIELD, R. R. WOLFE, et al. Decreased reliance on lactate during exercise after acclimatization to 4,300 m. J. Appl. Physiol. 71:333-341, 1991.
2. CASAS, M., H. CASAS, T. PAGÉS, et al. Effect of intermittent exposure to hypobaric hypoxia and exercise on human physical performance. J. Physiol. Biochem. (Rev. Esp. Fisiol.) 53:160, 1997.
3. CYMERMAN, A., J. T. REEVES, J. R. SUTTON., et al. Operation Everest II: maximal oxygen uptake at extreme altitude. J. Appl. Physiol. 66:2446-2453, 1989.
4. DRABKIN, D. L., and J. H. AUSTIN. Spectrophotometric studies: V. A technique for the analysis of undiluted blood and concentrated Hb solution. J. Biol. Chem. 112:105-115, 1935.
5. ECKARDT, K. U., U. BOUTELIER, A. KURTZ, M. SCHOPEN, E. A. KOLLER, and C. BAUER. Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J. Appl. Physiol. 66:1785-1788, 1989.
6. FERRETTI, G., V. BOUTELLIER, D. R. PENDERGAST, et al. Oxygen transport system before and after exposure to chronic hypoxia. Int. J. Sports Med. 11(Suppl. 1):S15-S20, 1990.
7. JONES, R. H., and B. A. MOLITORIS. A statistical method for determining the breakpoint of two lines. Anal. Biochem. 141:287-290, 1984.
8. KNAUPP, W., S. KHILNANI, J. SHERWOOD, S. SCHARF, and H. STEINBERG. Erythropoietin response to acute normobaric hypoxia in humans. J. Appl. Physiol. 73:837-840, 1992.
9. KOISTINEN, P., T. TAKALA, V. MARTIKKALA, and J. LEPPALUOTO. Aerobic fitness influences the response of maximal oxygen uptake and lactate threshold in acute hypobaric hypoxia. Int. J. Sports Med. 16:78-81, 1995.
10. LEVINE, B. D., and J. STRAY-GUNDERSEN. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J. Appl. Physiol. 83:102-112, 1997.
11. MADER, A., and H. HECK. A theory of the metabolic origin of the "anaerobic threshold." Int. J. Sports Med. 7:45-65, 1986.
12. REEVES, J. T., E. E. WOLFEL, H. J. GREEN, et al. Oxygen transport during exercise at altitude and the lactate paradox: lessons from operation Everest II and Pikes Peak. Exerc. Sport. Sci. Rev. 20: 275-296, 1992.
13. RICHALET, J. P., J. BITTEL, J. P. HERRY, et al. Use of a hypobaric chamber for pre-acclimatization before climbing Mount Everest. Int. J. Sports Med. 13(Suppl. 1):S216-S220, 1992.
14. SAVOUREY, G., N. GARCÍA, Y. BERNARD, A. GUINET, A. M. HANNIQUET, and J. BITTEL. Pre-adaptation, adaptation and de-adaptation to high altitude in humans: cardio-ventilatory and haematological changes. Eur. J. Appl. Physiol. 73:529-535, 1995.
15. SCHMIDT, W., K. U. ECKARDT, S. STRAUCH, and C. BAUER. Effects of maximal and submaximal exercise under normoxic and hypoxic conditions on serum erythropoietin level. Int. J. Sports Med. 12:457-461, 1991.
16. SULTAN, C., G. PRIOLET, Y. BEUZARD, R. ROSA, and F. JOSSO. Técnicas en Hematología. Barcelona: Toray, 1979, pp. 18-19.
17. SUTTON, J. R., J. T. REEVES, P. D. WAGNER, et al. Operation Everest II: oxygen transport during exercise at extreme simulated altitude. J. Appl. Physiol. 64:1039-1321, 1988.
18. TERRADOS, N., J. MELICHNA, CH. SYLVEN, E. JANSSON, and L. KAIJSER. Effects of training at simulated altitude on performance and muscle metabolic capacity in competitive road cyclists. Eur. J. Appl. Physiol 57:203-209, 1988.
19. TERRADOS, N. Altitude training and muscular metabolism. Int. J. Sports Med. 13(Suppl. 1):S206-S209, 1992.
20. VALLIER, J. M., P. CHATEAU, and C. Y. GUEZENNEC. Effects of physical training in a hypobaric chamber in the physical performance of competitive triathletes. Eur. J. Appl. Physiol. 73:471-478, 1996.
21. VAN BEAUMONT, W. Red cell volume with changes in plasma osmolarity during maximal exercise. J. Appl. Physiol. 35:47-50, 1973.
22. WAGNER, P. D., J. R. SUTON, J. T. REEVES, A. CYMERMAN, B. M. GROVES, and M. K. MALCONIAN. Operation Everest II: pulmonary gas exchange during simulated ascent of Mt. Everest. J. Appl. Physiol. 63:2348-2359, 1987.
23. WARD, M. P., J. S. MILLEDGE, and J. B. WEST. High Altitude Medicine and Physiology, 2nd Ed. London: Chapman & Hall Medical, 1995, p. 168.
24. WEST, J. B., S. LAHIRI, K. H. MARET, R. M. PETERS, and P. J. PIZZO. Barometric pressures at extreme altitudes on Mt. Everest; physiological significance. J. Appl. Physiol. 54:1188-1194, 1983.
25. ZEBALLOS, J., B. GALDÓS, and A. QUINTANILLA. Plasma osmolality in subjects acclimatised at high altitude. Lancet 3:230-231, 1973.