Alcohol effects during acamprosate treatment: A dose-response study in humans

Alcoholism: Clinical and Experimental Research

Volumn 28, Issue 7, 2004, Pages 1074-1083

  Brasser, Susan M ^a   McCaul, Mary E ^a   Houtsmuller, Elisabeth J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acamprosate; Alcohol; Ethanol; Human; Pharmacokinetics

Indexed keywords

ACAMPROSATE; ALCOHOL; PLACEBO;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRINKING BEHAVIOR; DROWSINESS; DRUG MECHANISM; FATIGUE; FEMALE; GASTROINTESTINAL SYMPTOM; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL PERFORMANCE; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; PROVOCATION TEST; SYSTOLIC BLOOD PRESSURE;

ADULT; ALCOHOL DRINKING; ALCOHOLIC INTOXICATION; ANALYSIS OF VARIANCE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ETHANOL; FEMALE; HUMANS; MALE; MIDDLE AGED; PSYCHOMOTOR PERFORMANCE; TAURINE;

ANIMALIA;

EID: 3242735793     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000130802.07692.29     Document Type: Article

References (62)

1. al Qatari M, Bouchenafa O, Littleton J (1998) Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res 22:810-814.
2. al Qatari M, Khan S, Harris B, Littleton J (2001) Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcohol Clin Exp Res 25:1276-1283.
3. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561-571.
4. B receptors in nucleus accumbens neurons. Alcohol Clin Exp Res 22:183-191.
5. Boismare F, Daoust M, Moore N, Saligaut C, Lhuintre JP, Chretien P, Durlach J (1984) A homotaurine derivative reduces the voluntary intake of ethanol by rats: are cerebral GABA receptors involved? Pharmacol Biochem Behav 21:787-789.
6. Chick J, Lehert P, Landron F (2002) Does acamprosate improve control of drinking as well as aiding abstinence (abstract)? Alcohol Clin Exp Res (Suppl) 26:84A.
7. Cole JC, Littleton JM, Little HJ (2000) Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology (Berl) 147:403-411.
8. COMBINE Study Research Group (2003a) Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: rationale and methods. Alcohol Clin Exp Res 27:1107-1122.
9. COMBINE Study Research Group (2003b) Testing combined pharmacotherapies and behavioral interventions for alcohol dependence (the COMBINE study): a pilot feasibility study. Alcohol Clin Exp Res 27:1123-1131.
10. Czachowski CL, Legg BH, Samson HH (2001) Effects of acamprosate on ethanol-seeking and self-administration in the rat. Alcohol Clin Exp Res 25:344-350.
11. Dahchour A, DeWitte P (1999) Acamprosate decreases the hypermotility during repeated ethanol withdrawal. Alcohol 18:77-81.
12. Daoust M, Legrand E, Gewiss M, Heidbreder C, DeWitte P, Tran G, Durbin P (1992) Acamprosate modulates synaptosomal GABA transmission in chronically alcoholised rats. Pharmacol Biochem Behav 41:669-674.
13. Davidson D, Palfai T, Bird C, Swift R (1999) Effects of naltrexone on alcohol self-administration in heavy drinkers. Alcohol Clin Exp Res 23:195-203.
14. Derogatis LR (1983) Administration, Scoring and Procedures Manual II. 2nd ed. Clinical Psychometric Research, Baltimore.
15. Gewiss M, Heidbreder C, Opsomer L, Durbin P, DeWitte P (1991) Acamprosate and diazepam differentially modulate alcohol-induced behavioural and cortical alterations in rats following chronic inhalation of ethanol vapour. Alcohol Alcohol 26:129-137.
16. Griffiths RR, Bigelow GE, Liebson I (1983) Differential effects of diazepam and pentobarbital on mood and behavior. Arch Gen Psychiatry 40:865-873.
17. Heyser CJ, Schulteis G, Durbin P, Koob GF (1998) Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 18:125-133.
18. Holter SM, Landgraf R, Zieglgansberger W, Spanagel R (1997) Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation. Alcohol Clin Exp Res 21:862-868.
19. Johansson B (1992) A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr Scand Suppl 369:15-26.
20. Johnson BA, O'Malley SS, Ciraulo DA, Roache JD, Chambers RA, Sarid-Segal O, Couper D (2003) Dose-ranging kinetics and behavioral pharmacology of naltrexone and acamprosate, both alone and combined, in alcohol-dependent subjects. J Clin Psychopharmacol 23:281-293.
21. Kiefer F, Jahn H, Tarnaske T, Helwig H, Briken P, Holzbach R, Kampf P, Stracke R, Baehr M, Naber D, Wiedemann K (2003) Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch Gen Psychiatry 60:92-99.
22. King AC, Volpicelli JR, Frazer A, O'Brien CP (1997) Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence. Psychopharmacology (Berl) 129:15-22.
23. Kirk T, Roache JD, Griffiths RR (1990) Dose-response evaluation of the amnestic effects of triazolam and pentobarbital in normal subjects. J Clin Psychopharmacol 10:160-167.
24. Koob GF, Mason BJ, DeWitte P, Littleton J, Siggins GR (2002) Potential neuroprotective effects of acamprosate. Alcohol Clin Exp Res 26:586-592.
25. LeMagnen J, Tran G, Durlach J (1987a) Lack of effects of Ca-acetyl homotaurinate on chronic and acute toxicities of ethanol in rats. Alcohol 4:103-108.
26. LeMagnen J, Tran G, Durlach J, Martin C (1987b) Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate. Alcohol 4:97-102.
27. Lhuintre JP, Daoust M, Moore ND, Chretien P, Saligaut C, Tran G, Boismare F, Hillemand B (1985) Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics. Lancet 1:1014-1016.
28. Lhuintre JP, Moore N, Tran G, Steru L, Langrenon S, Daoust M, et al. (1990) Acamprosate appears to decrease alcohol intake in weaned alcoholics. Alcohol Alcohol 25:613-622.
29. Littleton J (1995) Acamprosate in alcohol dependence: how does it work? Addiction 90:1179-1188.
30. Madamba SG, Schweitzer P, Zieglgansberger W, Siggins GR (1996) Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro. Alcohol Clin Exp Res 20:651-658.
31. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993) Development and validation of the Biphasic Alcohol Effects Scale. Alcohol Clin Exp Res 17:140-146.
32. Martin WR, Sloan JW, Sapira JD, Jasinski DR (1971) Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Ther 12:245-258.
33. Mason BJ (2001) Treatment of alcohol-dependent outpatients with acamprosate: a clinical review. J Clin Psychiatry (Suppl 20) 62:42-48.
34. Mason BJ, Goodman AM, Dixon RM, Hameed MH, Hulot T, Wesnes K, Hunter JA, Boyeson MG (2002) A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexone. Neuropsychopharmacology 27:596-606.
35. McCaul ME, Turkkan JS, Svikis DS, Bigelow GE (1991) Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects. Alcohol Clin Exp Res 15:94-101.
36. McCaul ME, Wand GS, Eissenberg T, Rohde CA, Cheskin LJ (2000) Naltrexone alters subjective and psychomotor responses to alcohol in heavy drinking subjects. Neuropsychopharmacology 22:480-492.
37. McLeod DR, Griffiths RR, Bigelow GE, Yingling J (1982) An automated version of the digit symbol substitution test (DSST). Behav Res Methods Instrum 14:463-466.
38. McNair DM, Lorr M, Droppleman LF (1971) EITS Manualfor the Profile of Mood States. Educational and Industrial Testing Services, San Diego.
39. Naassila M, Hammoumi S, Legrand E, Durbin P, Daoust M (1998) Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 22:802-809.
40. Olive MF, Nannini MA, Ou CJ, Koenig HN, Hodge CW (2002) Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release. Eur J Pharmacol 437:55-61.
41. O'Malley SS, Krishnan-Sarin S, Farren C, Sinha R, Kreek MJ (2002) Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary- adrenocortical axis. Psychopharmacology (Berl) 160:19-29.
42. Paille FM, Guelfi JD, Perkins AC, Royer RJ, Steru L, Parot P (1995) Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol. Alcohol Alcohol 30:239-247.
43. Palfai T, Davidson D, Swift R (1999) Influence of naltrexone on cue-elicited craving among hazardous drinkers: the moderational role of positive outcome expectancies. Exp Clin Psychopharmacol 7:266-273.
44. Pelc I, Verbanck P, LeBon O, Gavrilovic M, Lion K, Lehert P (1997) Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients: a 90-day placebo-controlled dose-finding study. Br J Psychiatry 171:73-77.
45. Petersen EN (1992) The pharmacology and toxicology of disulfiram and its metabolites. Acta Psychiatr Scand Suppl 369:7-13.
46. Popp RL, Lovinger DM (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur J Pharmacol 394:221-231.
47. Putzke J, Spanagel R, Tolle TR, Zieglgansberger W (1996) The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal. Eur J Pharmacol 317:39-48.
48. Quertemont E, Brabant C, De Witte P (2002) Acamprosate reduces context-dependent ethanol effects. Psychopharmacology (Berl) 164:10-18.
49. Saivin S, Hulot T, Chabac S, Potgieter A, Durbin P, Houin G (1998) Clinical pharmacokinetics of acamprosate. Clin Pharmacokinet 35:331-345.
50. Sass H, Soyka M, Mann K, Zieglgansberger W (1996) Relapse prevention by acamprosate: results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry 53:673-680.
51. Schneider U, Wohlfahrt K, Schulze-Bonhage A, Haacker T, Caspary A, Zedler M, Emrich HM (1998) Lack of psychotomimetic or impairing effects on psychomotor performance of acamprosate. Pharmacopsychiatry 31:110-113.
52. Schuckit MA (1980) Self-rating of alcohol intoxication by young men with and without family histories of alcoholism. J Stud Alcohol 41:242-249.
53. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry (Suppl 20) 59:22-33.
54. Soyka M, Aichmuller C, Preuss U, Moller HJ (1998) Effects of acamprosate on psychomotor performance and driving ability in abstinent alcoholics. Pharmacopsychiatry 31:232-235.
55. Spanagel R, Holter SM, Allingham K, Landgraf R, Zieglgansberger W (1996a) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305:39-44.
56. Spanagel R, Putzke J, Stefferl A, Schobitz B, Zieglgansberger W (1996b) Acamprosate and alcohol: II. Effects on alcohol withdrawal in the rat. Eur J Pharmacol 305:45-50.
57. Spanagel R, Zieglgansberger W, Hundt W (1996c) Acamprosate and alcohol: III. Effects on alcohol discrimination in the rat. Eur J Pharmacol 305:51-56.
58. Swift RM, Whelihan W, Kuznetsov O, Buongiorno G, Hsuing H (1994) Naltrexone-induced alterations in human ethanol intoxication. Am J Psychiatry 151:1463-1467.
59. Weinstein A, Feldtkeller B, Feeney A, Lingford-Hughes A, Nutt D (2003) A pilot study on the effects of treatment with acamprosate on craving for alcohol in alcohol-dependent patients. Addict Biol 8:229-232.
60. Whitworth AB, Fischer F, Lesch OM, Nimmerrichter A, Oberbauer H, Platz T, Potgieter A, Walter H, Fleischhacker WW (1996) Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. Lancet 347:1438-1442.
61. Wilde MI, Wagstaff AJ (1997) Acamprosate: a review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification. Drugs 53:1038-1053.
62. Zeise ML, Kasparov S, Capogna M, Zieglgansberger W (1993) Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors. Eur J Pharmacol 231:47-52.