Discrepant recovery course of sympathetic neuronal function and β-adrenoceptors in rat hearts after reperfusion following transient ischemia

Journal of Nuclear Medicine

Volumn 45, Issue 6, 2004, Pages 1074-1080

  Kato, Bun Ichi ^a   Nozawa, Takashi ^a   Igarashi, Norio ^a   Nonomura, Makoto ^a   Fujii, Nozomu ^a   Igawa, Akihiko ^a   Asanoi, Hidetsugu ^a   Yamada, Yoshihisa ^b   Inoue, Minoru ^c   Inoue, Hiroshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c Daiichi Radioisotope Laboratories Ltd   (Japan)

Author keywords

adrenergic receptor; Myocardial ischemia; Radioisotopes; Reperfusion; Sympathetic nervous system

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 131; BETA ADRENERGIC RECEPTOR; CYANOPINDOLOL I 125; NORADRENALIN; THALLIUM 201; (3 IODOBENZYL)GUANIDINE; CYANOIODOPINDOLOL; DIAGNOSTIC AGENT; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG STRUCTURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEMODYNAMICS; LEFT CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ADAPTATION; ANIMAL; AUTONOMIC NEUROPATHY; CONVALESCENCE; HEART; HEART MUSCLE; INNERVATION; METABOLIC CLEARANCE RATE; METABOLISM; NERVE CELL; PHYSIOLOGY; REPERFUSION INJURY; SCINTISCANNING; TISSUE DISTRIBUTION; WISTAR RAT;

3-IODOBENZYLGUANIDINE; ADAPTATION, PHYSIOLOGICAL; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; HEART; IODINE RADIOISOTOPES; IODOCYANOPINDOLOL; MALE; METABOLIC CLEARANCE RATE; MYOCARDIUM; NEURONS; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; RECOVERY OF FUNCTION; REPERFUSION INJURY; TISSUE DISTRIBUTION;

EID: 3242720689     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Lameris TW, de Zeeuw S, Alberts G, et al. Time course and mechanism of myocardial catecholamine release during transient ischemia in vivo. Circulation. 2000;101:2645-2650.
2. Schömig A. Catecholamines in myocardial ischemia: systemic and cardiac release. Circulation. 1990;82(suppl II):II-13-II-22.
3. Akiyama T, Yamazaki T. Myocardial interstitial norepinephrine and dihydroxyphenylglycol levels during ischemia and reperfusion. Cardiovasc Res. 2000;49:78-85.
4. Stanton MS, Tuli MM, Radtke NL, et al. Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123-metaiodobenzylguanidine. J Am Coll Cardiol. 1989;14:1519-1526.
5. Dae MW, Herre JM, O'Connell JW, Botvinick EH, Newman D, Munoz L. Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction. J Am Coll Cardiol. 1991;17:1416-1423.
6. Nishimura T, Oka H, Sago M, et al. Serial assessment of denervated but viable myocardium following acute myocardial infarction in dogs using iodine-123 metaiodobenzylguanidine and thallium-201 chloride myocardial single photon emission tomography. Eur J Nucl Med. 1992;19:25-29.
7. Igawa A, Nozawa T, Yoshida N, et al. Heterogeneous cardiac sympathetic innervation in heart failure after myocardial infarction of rats. Am J Physiol. 2000;278:H1134-H1141.
8. Dae MW, O'Connell JW, Botvinick EH, Chin MC. Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content. Cardiovasc Res. 1995;30:270-280.
9. Watanabe K, Takahashi T, Miyajima S, et al. Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic angina. J Nucl Med. 2002;43:1476-1481.
10. Böhm M, La Rosee K, Schwinger RHG, Erdmann E. Evidence for reduction of norepinephrine uptake sites in the failing human heart. J Am Coll Cardiol. 1995;25:146-153.
11. Nozawa T, Igawa A, Yoshida N, et al. Dual-tracer assessment of coupling between cardiac sympathetic neuronal function and downregulation of β-receptors during development of hypertensive heart failure of rats. Circulation. 1998;97:2359-2367.
12. Maisel AS, Motulsky HJ, Insel PA. Externalization of β-adrenergic receptors promoted by myocardial ischemia. Science. 1985;230:183-186.
13. Mukherjee A, Bush LR, McCoy KE, et al. Relationship between β-adrenergic receptor numbers and physiological responses during experimental canine myocardial ischemia. Circ Res. 1982;50:735-741.
14. Karliner JS, Stevens MB, Honbo N, Hoffman JIE. Effects of acute ischemia in the dog on myocardial blood flow, beta receptors, and adenylate cyclase activity with and without chronic beta blockade. J Clin Invest. 1989;83:474-481.
15. Kiuchi K, Shen Y-T, Vatner SF, Vatner DE. Mechanisms mediating responsiveness to β-adrenergic stimulation after coronary reperfusion in conscious dogs. Am J Physiol. 1994;267:H1578-H1588.
16. Persad S, Takeda S, Panagia V, Dhalla NS. β-Adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals. J Mol Cell Cardiol. 1997;29:545-558.
17. Sato S, Naoki S, Kudej RK, et al. β-Adrenergic receptor signalling in stunned myocardium of conscious pigs. J Mol Cell Cardiol. 1997;29:1387-1400.
18. Allman KC, Wieland DM, Muzik O, Degrado TR, Wolfe ER Jr, Schwaiger M. Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans. J Am Coll Cardiol. 1993;22:368-375.
19. Eisenhofer G, Friberg P, Rundqvist B, et al. Cardiac sympathetic nerve function in congestive heart failure. Circulation. 1996;93:1667-1676.
20. Merlet P, Valette H, Dubois-Randé J-L, et al. Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure. J Nucl Med. 1992;33:471-477.
21. Schofer J, Spielmann R, Schuchert A, Weber K, Schlüter M. Iodine-123 metaiodobenzylguanidine scintigraphy: a noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 1988;12:1252-1258.
22. Delehanty JM, Himura Y, Elam H, Hood WB Jr, Liang CS. β-Adrenoceptor downregulation in pacing-induced heart failure is associated with increased interstitial NE content. Am J Physiol. 1994;266:H930-H935.
23. 123I]iodocyanopindolol. Appl Radiat Isot. 1991;42:309-311.
24. Nakajo M, Shimabukuro K, Yoshimura H, et al. Iodine-131 metaiodobenzylguanidine intra- and extravesicular accumulation in the rat heart. J Nucl Med. 1986;27:84-89.
25. Weiland DM, Brown LE, Rogers WL, et al. Myocardial imaging with a radioiodinated norepinephrine storage analog. J Nucl Med. 1981;22:22-31.
26. Sisson JC, Wieland DM, Sherman P, Mangner TJ, Tobes MC, Jacques S Jr. Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function. J Nucl Med. 1987;28:1620-1624.
27. Dae MW, O'Connell JW, Botvinick EH, et al. Scintigraphic assessment of regional cardiac adrenergic innervation. Circulation. 1989;79:634-644.
28. Somsen GA, Dubois EA, Brandsma K, et al. Cardiac sympathetic neuronal function in left ventricular volume and pressure overload. Cardiovasc Res. 1996;31:132-138.
29. Inobe Y, Kugiyama K, Miyagi H, et al. Long-lasting abnormalities in cardiac sympathetic nervous system in patients with coronary spastic angina: quantitative analysis with iodine 123 metaiodobenzylguanidine myocardial scintigraphy. Am Heart J. 1997;134:112-118.
30. Iwasaki T, Suzuki T, Tateno M, Sasaki Y, Oshima S, Imai S. Dual-tracer autoradiography with thallium-201 and iodine-125-metaiodobenzylguanidine in experimental myocardial infarction of rat. J Nucl Med. 1996;37:680-684.
31. Obata T, Hosokawa H, Yamanaka Y. In vivo monitoring of norepinephrine and OH generation on myocardial ischemic injury by dialysis technique. Am J Physiol. 1994;266:H903-H908.
32. Liang CS, Rounds NK, Dong E, Stevens SY, Shite J, Qin F. Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial β-adrenergic receptor sensitivity in the ferret: normalization by antioxidant vitamins. Circulation. 2000;102:96-103.
33. Teixeira AA, Azevedo I, Branco D, Rodrigues-Pereira E, Osswald W. Sympathetic denervation caused by long-term noradrenaline infusions: prevention by desipramine and superoxide dismutase. Br J Pharmacol. 1989;97:95-102.
34. Hughes B, Marshall DR, Sobel BE, Bergmann SR. Characterization of betaadrenoreceptors in vivo with iodine-131 pindolol and gamma scintigraphy. J Nucl Med. 1986;27:660-667.
35. Sisson JC, Wieland DM, Koeppe RA, et al. Scintigraphic portrayal of β-receptors in the heart. J Nucl Med. 1991;32:1399-1407.
36. Bartels LA, Clifton GD, Szabo TS. Influence of myocardial ischemia and reperfusion on β-adrenoceptor subtype expression. J Cardiovasc Pharmacol. 1998;31:484-487.
37. Iwase T, Murakami T, Tomita T, Miki S, Nagai K, Sasayama S. Ischemic preconditioning is associated with a delay in ischemia-induced reduction of β-adrenergic signal transduction in rabbit hearts. Circulation. 1993;88:2827-2837.
38. Persad S, Rupp H, Jindal R, Arneja J, Dhalla NS. Modification of cardiac β-adrenoceptor mechanisms by H2O2. Am J Physiol. 1998;274:H416-H423.
39. Holmgren S, Abrahamsson T, Almgren O, Eriksson B-M. Effect of ischemia on the adrenergic neurons of the rat heart: a fluorescence histochemical and biochemical study. Cardiovasc Res. 1981;15:680-689.
40. 131I]metaiodobenzylguanidine after ischemia and reperfusion in anesthetized dogs. J Nucl Cardiol. 1997;4:33-41.