A synthetic peptide derived from the human eosinophil-derived neurotoxin induces apoptosis in Kaposi's sarcoma cells

Anticancer Research

Volumn 24, Issue 3 A, 2004, Pages 1427-1432

  Dricu, Anica ^a   Sergiu Bogdan, Catrina ^a   Brismar, Kerstin ^a   Biberfeld, Peter ^a   Andersson, Leif C ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

AIDS; Apoptosis; hCG; Human eosinophil derived neurotoxin; Kaposi's sarcoma

Indexed keywords

CHORIONIC GONADOTROPIN; EOSINOPHIL PROTEIN X; RIBONUCLEASE; SYNTHETIC PEPTIDE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CELL LINE; CELL SPECIFICITY; CELL STRAIN KSIMM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; HUMAN; HUMAN CELL; KAPOSI SARCOMA; MELANOMA CELL; MOLECULAR RECOGNITION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

APOPTOSIS; CELL LINE, TUMOR; CHORIONIC GONADOTROPIN; EOSINOPHIL-DERIVED NEUROTOXIN; FIBROBLASTS; HUMANS; OLIGOPEPTIDES; RIBONUCLEASES; SARCOMA, KAPOSI;

EID: 3242715135     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Jacobson LP, Yamashita TE, Detels R, Margolick JB, Chmiel JS, Kingsley LA, Melnick S and Munoz A: Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1-infected individuals. Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 21 Suppl 1: S34-S41, 1999.
2. Antman K and Chang Y: Kaposi's sarcoma. N Engl J Med 342: 1027-1038, 2000.
3. Lunardi-Iskandar Y, Bryant JL, Zeman RA, Lam VH, Samaniego F, Besnier JM, Hermans P, Thierry AR, Gill P and Gallo RC: Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Nature 375: 64-68, 1995.
4. Gill PS, Lunardi-Ishkandar Y, Louie S, Tulpule A, Zheng T, Espina BM, Besnier JM, Hermans P, Levine AM, Bryant JL and Gallo RC: The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi's sarcoma. N Engl J Med 335: 1261-1269, 1996.
5. Simonart T, Van Vooren JP and Meuris S: Treatment of Kaposi's sarcoma with human chorionic gonadotropin. Dermatology 204: 330-333, 2002.
6. Lang ME, Lottersberger C, Roth B, Bock G, Recheis H, Sgonc R, Sturzl M, Albini A, Tschachler E, Zangerle R, Donini S, Feichtinger H and Schwarz S: Induction of apoptosis in Kaposi's sarcoma spindle cell cultures by the subunits of human chorionic gonadotropin. AIDS 11: 1333-1340, 1997.
7. Samaniego F, Bryant JL, Liu N, Karp JE, Sabichi AL, Thierry A, Lunardi-Iskandar Y and Gallo RC: Induction of programmed cell death in Kaposi's sarcoma cells by preparations of human chorionic gonadotropin. J Natl Cancer Inst 91: 135-143, 1999.
8. Bisacchi D, Noonan DM, Carlone S, Albini A and Pfeffer U: Kaposi's sarcoma and human chorionic gonadotropin: mechanisms, moieties and mysteries. Biol Chem 383: 1315-1320, 2002.
9. Griffiths SJ, Adams DJ and Talbot SJ: Ribonuclease inhibits Kaposi's sarcoma. Nature 390: 568, 1997.
10. Griffiths SJ, Bramley TA, Menzies GS and Adams DJ: Co-purification of a ribonuclease and human chorionic gonadotrophin beta-core protein from human urine and displacement of 125I-human luteinizing hormone from Candida albicans binding sites by ribonucleases. Mol Cell Endocrinol 134: 69-76, 1997.
11. Sakakibara R, Hashida K, Tominaga N, Sakai K, Ishiguro M, Imamura S, Ohmatsu F and Sato E: A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease. Chem Pharm Bull (Tokyo) 39: 146-149, 1991.
12. Newton DL, Nicholls PJ, Rybak SM and Youle RJ: Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophil-derived neurotoxin-anti-transferrin receptor sFv. J Biol Chem 269: 26739-26745, 1994.
13. Chang C, Newton DL, Rybak SM and Wlodawer A: Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities. J Mol Biol 317: 119-130, 2002.
14. Catrina SB, Catrina AI, Sirzen F, Griffiths W, Bergman T, Biberfeld P, Coculescu M and Mutt V: A cytotoxic, apoptotic, low-molecular weight factor from pineal gland. Life Sci 65: 1047-1057, 1999.
15. Manjunath P and Sairam MR: Biochemical, biological, and immunological properties of chemically deglycosylated human choriogonadotropin. J Biol Chem 257: 7109-7115, 1982.
16. Hermans P, Clumeck N, Picard O, Van Vooren JP, Duriez P, Zucman D, Bryant JL, Gill P, Lunardi-Iskandar Y and Gallo RC: AIDS-related Kaposi's sarcoma patients with visceral manifestations. Response to human chorionic gonadotropin preparations. J Hum Virol 1: 82-89, 1998.
17. Simonart T, Hermans P, Van Vooren JP and Meuris S: Paradoxical pro-Kaposi's sarcoma activity of preparations of human chorionic gonadotropin. Blood 94: 376-377, 1999.
18. Saxena SK, Rybak SM, Winkler G, Meade HM, McGray P, Youle RJ and Ackerman EJ: Comparison of RNases and toxins upon injection into Xenopus oocytes. J Biol Chem 266: 21208-21214, 1991.
19. Newton DL, Boque L, Wlodawer A, Huang CY and Rybak SM: Single amino acid substitutions at the N-terminus of a recombinant cytotoxic ribonuclease markedly influence biochemical and biological properties. Biochemistry 37: 5173-5183, 1998.
20. Newton DL and Rybak SM: Unique recombinant human ribonuclease and inhibition of Kaposi's sarcoma cell growth. J Natl Cancer Inst 90: 1787-1791, 1998.
21. Coffey RJ Jr, Leof EB, Shipley GD and Moses HL: Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells. J Cell Physiol 132: 143-148, 1987.