Extracellular DNA in breast cancer: Cell-surface-bomnd, tumor-derived extracellular DNA in blood of patients with breast cancer and nonmalignant tumors

Annals of the New York Academy of Sciences

Volumn 1022, Issue , 2004, Pages 217-220

  Rykova, Elena Yu ^a   Laktionov, Pavel P ^a   Skvortsova, Tatyana E ^a   Starikov, Andrey V ^b   Kuznetsova, Nina P ^b   Vlassov, Valentin V ^a  

^a INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^b National Novosibirsk Regional Oncologic Dispensary   (Russian Federation)

Author keywords

Blood; Breast cancer; Extracellular DNA (exDNA); Methylation specific polymerase chain reaction; Plasma

Indexed keywords

DNA; HIC 1 PROTEIN; PROTEIN; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; UNCLASSIFIED DRUG;

BREAST CANCER; BREAST FIBROADENOMA; CANCER DIAGNOSIS; CANCER EPIDEMIOLOGY; CELL SURFACE; CONFERENCE PAPER; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DNA DETERMINATION; ERYTHROCYTE; FIBROADENOMA; HUMAN; LEUKOCYTE; METHYLATION; POLYMERASE CHAIN REACTION;

EID: 3242685870     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1318.033     Document Type: Conference Paper

References (10)

1. Tsou, J.A. et al. 2002. DNA methylation analysis: a powerful new tool for lung cancer diagnostics. Oncogene 21: 5450-5461.
2. ANKER, P. et al. 1999. Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev. 18: 65-73.
3. CHAN, A.K. et al. 2003. Cell-free nucleic acids in plasma, serum and urine: a new tool in molecular diagnosis. Ann. Clin. Biochem. 40: 122-130.
4. LAKTIONOV, P.P. et al. 2004. Free and cell surface bound nucleic acids in blood of healthy donors and breast cancer patients. Ann. N.Y. Acad. Sci. In press.
5. LAKTIONOV, P. et al., inventors; Laktionov, P. & V. Vlassov, assignees. 2002. Russian patent 2002126328. Date of application: October 2.
6. HERMAN, J.G. et al. 1996. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93: 9821-9826.
7. LAKTIONOV, P. et al., inventors; Laktionov, P. & V. Vlassov, assignees. 2002. Russian-patent 20022134341. Date of application: December 19.
8. DONG, S.M. et al. 2001. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin. Cancer Res. 7: 1982-1986.
9. BURBEE, D.G. et al. 2001. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J. Natl. Cancer Inst. 93: 691-699.
10. NICOLL, G. et al. 2001. Expression of the hypermethylated in cancer gene HIC-1 is associated with good outcome in human breast cancer. Br. J. Cancer 85: 1878-1882.