Genetic assocaition between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene

Genes and Immunity

Volumn 5, Issue 4, 2004, Pages 310-312

  Smerdel, A ^a   Dai, K Z ^b   Lorentzen, A R ^a   Flato B ^a   Maslinski, S ^c   Thorsby, E ^a   Forre O ^a   Spurkland, Ana ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c INSTITUTE OF RHEUMATOLOGY   (Poland)

Author keywords

Juvenile rheumatoid arthritis; SH2D2A gene; T cell specific adapter protein

Indexed keywords

ADENOSINE; GUANINE; HLA DR ANTIGEN; PROTEIN SH2; PROTEIN SH2D2A; UNCLASSIFIED DRUG; SH2D2A PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALLELE; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOPATHOGENESIS; JUVENILE RHEUMATOID ARTHRITIS; MAJOR CLINICAL STUDY; NORWAY; PRIORITY JOURNAL; PROMOTER REGION; SRC HOMOLOGY DOMAIN; STATISTICAL SIGNIFICANCE; GENETIC PREDISPOSITION; GENETICS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ARTHRITIS, JUVENILE RHEUMATOID; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 3242682494     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6364093     Document Type: Article

References (16)

1. Spurkland A, Brinchmann JE, Markussen G et al. Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. J Biol Chem 1998; 273: 4539-4546.
2. Sundvold V, Torgersen KM, Post NH et al. T cell-specific adapter protein inhibits T cell activation by modulating Lck activity. J Immunol 2000; 165: 2927-2931.
3. Marti F, Post NH, Chan E et al. A transcription function for the T cell-specific adapter (TSAd) protein in T cells: critical role of the TSAd Src homology 2 domain. J Exp Med 2001; 193: 1425-1430.
4. Drappa J, Kamen LA, Chan E et al. Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice. J Exp Med 2003; 198: 809-821.
5. Dai KZ, Vergnaud G, Ando A et al. The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human chromosome 1. Immunogenetics 2000; 51: 179-185.
6. Dai KZ, Johansen FE, Melkevik-Kolltveit K et al. Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5′ monophosphate responsive element in the proximal SH2D2A promoter. J Immunol 2004; 172.
7. Dai KZ, Harbo HF, Celius EG et al. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis. Genes Immun 2001; 2: 263-268.
8. Moore TL. Immunopathogenesis of juvenile rheumatoid arthritis. Curr Opin Rheumatol 1999; 11: 377-383.
9. Murray K, Thompson SD, Glass DN. Pathogenesis of juvenile chronic arthritis: genetic and environmental factors. Arch Dis Child 1997; 77: 530-534.
10. Glass DN, Giannini EH. Juvenile rheumatoid arthritis as a complex genetic trait. Arthritis Rheum 1999; 42: 2261-2268.
11. Forre O, Smerdel A. Genetic epidemiology of juvenile idiopathic arthritis. Scand J Rheumatol 2002; 31: 123-128.
12. Albert E, Ansell BM. Immunogenetics of juvenile chronic arthritis. Scand J Rheumatol Suppl 1987; 66: 85-91.
13. Smerdel A, Ploski R, Flato B et al. Juvenile idiopathic arthritis (JIA) is primarily associated with HLA-DR8 but not DQ4 on the DR8-DQ4 haplotype. Ann Rheum Dis 2002; 61: 354-357.
14. Sundvall M, Jirholt J, Yang HT et al. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat Genet 1995; 10: 313-317.
15. Jirholt J, Cook A, Emahazion T et al. Genetic linkage analysis of collagen-induced arthritis in the mouse. Eur J Immunol 1998; 28: 3321-3328.
16. Flato B, Smerdel A, Johnston V et al. The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. Arthritis Rheum 2002; 46: 986-994.