Detection of chronic sensorimotor impairments in the ladder rung walking task in rats with endothelin-1-induced mild focal ischemia

Journal of Neuroscience Methods

Volumn 137, Issue 2, 2004, Pages 227-233

  Riek Burchardt, Monika ^a   Henrich Noack, Petra ^b   Metz, Gerlinde A ^c   Reymann, Klaus G ^a,b  

^a LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^b Res Inst of Applied Neurosciences   (Germany)

^c UNIVERSITY OF LETHBRIDGE   (Canada)

Author keywords

Endothelin 1; Focal ischemia; Functional recovery; Functional test; Ladder rung walking task; Long term measurement; Sensorimotor deficits

Indexed keywords

ENDOTHELIN 1; HALOTHANE;

ANESTHESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CANNULA; CONTROLLED STUDY; ERROR; EVALUATION; FORELIMB; HINDLIMB; MALE; MOTOR COORDINATION; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PSYCHOLOGIC TEST; RAT; SENSORIMOTOR CORTEX; TASK PERFORMANCE; WAKEFULNESS; WALKING;

ANESTHETICS, INHALATION; ANIMALS; BEHAVIOR, ANIMAL; BRAIN INFARCTION; BRAIN ISCHEMIA; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; HALOTHANE; HINDLIMB; MALE; PHYSICAL CONDITIONING, ANIMAL; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; SOMATOSENSORY CORTEX; STATISTICS, NONPARAMETRIC; TIME FACTORS; WAKEFULNESS; WALKING;

EID: 3242673422     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2004.02.012     Document Type: Article

References (24)

1. Bao W.L., Williams A.J., Faden A.I., Tortella F.C. Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. Brain Res. 922:2001;173-179
2. Barbelivien A., Jolkkonen J., Rutkauskaite E., Sirvio J., Sivenius J. Differentially altered cerebral metabolism in ischemic rats by alpha2-adrenoceptor blockade and its relation to improved limb-placing reactions. Neuropharmacology. 42:2002;117-126
3. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 17:1986;472-476
4. Belayev L., Alonso O.F., Busto R., Zhao W., Ginsberg M.D. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke. 27:1996;1616-1622., discussion 1623
5. Goto K., Hama H., Kasuya Y. Molecular pharmacology and pathophysiological significance of endothelin. Jpn. J. Pharmacol. 72:1996;261-290
6. Hunter A.J., Mackay K.B., Rogers D.C. To what extent have functional studies of ischaemia in animals been useful in the assessment of potential neuroprotective agents? Trends Pharmacol. Sci. 19:1998;59-66
7. Hunter A.J., Hatcher J., Virley D., Nelson P., Irving E., Hadingham S.J., et al. Functional assessments in mice and rats after focal stroke. Neuropharmacology. 39:2000;806-816
8. Kirino T. Ischemic tolerance. J. Cereb. Blood Flow Metab. 22(11):2002;1283-1296
9. Lindvall O., McKay R. Brain repair by cell replacement and regeneration. Proc. Natl. Acad. Sci. U.S.A. 100(13):2003;7430-7431., Epub 16 June 2003
10. Markgraf C.G., Green E.J., Hurwitz B.E., Morikawa E., Dietrich W.D., McCabe P.M., et al. Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats. Brain Res. 575:1992;238-246
11. Marston H.M., Faber E.S., Crawford J.H., Butcher S.P., Sharkey J. Behavioural assessment of endothelin-1 induced middle cerebral artery occlusion in the rat. Neuroreport. 6:1995;1067-1071
12. Metz G.A., Whishaw I.Q. Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination. J. Neurosci. Methods. 115:2002;169-179
13. Moyanova S., Kirov R., Kortenska L. Multi-unit activity suppression and sensorimotor deficits after endothelin-1-induced middle cerebral artery occlusion in conscious rats. J. Neurol. Sci. 212:2003;59-67
14. Nakatomi H., Kuriu T., Okabe S., Yamamoto S., Hatano O., Kawahara N., et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell. 110:2002;429-441
15. Persson L., Hardemark H.G., Bolander H.G., Hillered L., Olsson Y. Neurologic and neuropathologic outcome after middle cerebral artery occlusion in rats. Stroke. 20:1989;641-645
16. Pringle A.K., Schmidt W., Deans J.K., Wulfert E., Reymann K.G., Sundstrom L.E. 7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro. Eur. J. Neurosci. 18:2003;117-124
17. Puurunen K., Jolkkonen J., Sirvio J., Haapalinna A., Sivenius J. An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology. 40:2001;597-606
18. Quartermain D., Li Y., Jonas S. Enoxaparin, a low molecular weight heparin decreases infarct size and improves sensorimotor function in a rat model of focal cerebral ischemia. Neurosci. Lett. 288:2000;155-158
19. Rauca C., Henrich-Noack P., Schäfer K., Höllt V., Reymann K.G. (S)-4C3HPG reduces infarct size after focal cerebral ischemia. Neuropharmacology. 37:1998;1649-1652
20. Sharkey J, Butcher SP. Characterisation of an experimental model of stroke produced by intracerebral microinjection of endothelin-1 adjacent to the rat middle cerebral artery. J Neurosci Methods 1995;60:125-31.
21. van der Staay F.J., Augstein K.H., Horvath E. Sensorimotor impairments in Wistar Kyoto rats with cerebral infarction, induced by unilateral occlusion of the middle cerebral artery: recovery of function. Brain Res. 715:1996;180-188
22. Winner B., Cooper-Kuhn C.M., Aigner R., Winkler J., Kuhn H.G. Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb. Eur. J. Neurosci. 16:2002;1681-1689
23. Wood N.I., Sopesen B.V., Roberts J.C., Pambakian P., Rothaul A.L., Hunter A.J., et al. Motor dysfunction in a photothrombotic focal ischaemia model. Behav. Brain Res. 78:1996;113-120
24. Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 332:1988;411-415