Microglia phagocytose alloreactive CTL-damaged 9L gliosarcoma cells

Journal of Neuroimmunology

Volumn 153, Issue 1-2, 2004, Pages 76-82

  Kulprathipanja, Nisha V ^a   Kruse, Carol A ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b LA JOLLA INSTITUTE FOR MOLECULAR MEDICINE   (United States)

Author keywords

Antigen presentation; Apoptosis; CTL; Glioma; Microglia; Phagocytosis

Indexed keywords

CYTOKINE;

ADOPTIVE IMMUNOTHERAPY; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN; CELL ACTIVITY; CELL INTERACTION; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; GLIOMA CELL; GLIOSARCOMA; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE CULTURE; MICROGLIA; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SARCOMA CELL; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL;

ANIMALS; ANIMALS, NEWBORN; ANNEXIN A5; ANTIGENS, CD11B; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHALASIN D; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; GLIOSARCOMA; IMMUNOTHERAPY, ADOPTIVE; MICROGLIA; NUCLEIC ACID SYNTHESIS INHIBITORS; PHAGOCYTOSIS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 3242658002     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2004.04.011     Document Type: Article

References (45)

1. Badie B., Schartner J.M. Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery. 46:2000;957-961
2. Badie B., Schartner J. Role of microglia in glioma biology. Microsc. Res. Tech. 54:2001;106-113
3. Becher B., Antel J.P. Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia. 18:1996;1-10
4. Carson M.J., Reilly C.R., Sutcliffe J.G., Lo D. Mature microglia resemble immature antigen-presenting cells. Glia. 22:1998;72-85
5. Carson M.J., Sutcliffe J.G., Campbell I.L. Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation. J. Neurosci. Res. 55:1999;127-134
6. Chang G.H.F., Barbaro N.M., Pieper R.O. Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells. Neuro-Oncology. 2:2000;174-183
7. Darzynkiewicz Z., Juan G., Li X., Gorczyca W., Murakami T., Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry. 27:1997;1-20
8. Fadok V.A., Bratton D.L., Guthrie L., Henson P.M. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J. Immunol. 166:2001;6847-6854
9. Fakhrai H., Dorigo O., Shawler D.L., Lin H., Mercola D., Black K.L., Royston I., Sobol R.E. Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. Proc. Natl. Acad. Sci. U. S. A. 93:1996;2909-2914
10. Finkel E. Biomedicine - does cancer therapy trigger cell suicide? Science. 286:1999;2256-2258
11. Fleshner M., Watkins L.R., Redd J.M., Kruse C.A., Bellgrau D. A 9L gliosarcoma transplantation model for studying adoptive immunotherapy into the brains of conscious rats. Cell Transplant. 1:1992;307-312
12. Flugel A., Labeur M.S., Grasbon-Frodl E.M., Kreutzberg G.W., Graeber M.B. Microglia only weakly present glioma antigen to cytotoxic T cells. Int. J. Dev. Neurosci. 17:1999;547-556
13. Ford A.L., Goodsall A.L., Hickey W.F., Sedgwick J.D. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J. Immunol. 154:1995;4309-4321
14. Gillespie G.Y. Cytokines as modulators of malignant glioma progression. Ransohoff R.M., Benveniste E.N. Cytokines and the CNS. 1996;269-286 CRC Press, Boca Raton
15. Gomez G.G., Read S.B., Gerschenson L.E., Santoli D., Zweifach A., Kruse C.A. Interactions of the allogeneic effector leukemic T cell line, TALL-104, with human malignant brain tumors. Neuro-Oncology. 6:2004;83-95. Available at: http://neuro-oncology.mc.duke.edu
16. Graeber M.B., Scheithauer B.W., Kreutzberg G.W. Microglia in brain tumors. Glia. 40:2002;252-259
17. Grau V., Herbst B., VanderMeide P.H., Steiniger B. Activation of microglial and endothelial cells in the rat brain after treatment with interferon-gamma in vivo. Glia. 19:1997;181-189
18. Hao C.H., Parney I.F., Roa W.H., Turner J., Petruk K.C., Ramsay D.A. Cytokine and cytokine receptor mRNA expression in human glioblastomas: evidence of Th1, Th2 and Th3 cytokine dysregulation. Acta Neuropathol. 103:2002;171-178
19. Henkart P.A., Williams M.S., Zacharchuk C.M., Sarin A. Do CTL kill target cells by inducing apoptosis? Semin. Immunol. 9:1997;135-144
20. Hirt U.A., Leist M. Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells. Cell Death Differ. 10:2003;1156-1164
21. Jerome K.R., Sloan D.D., Aubert M. Measurement of CTL-induced cytotoxicity: the caspase 3 assay. Apoptosis. 8:2003;563-571
22. Jersmann H.P.A., Ross K.A., Vivers S., Brown S.B., Haslett C., Dransfield I. Phagocytosis of apoptotic cells by human macrophages: analysis by multiparameter flow cytometry. Cytometry Part A. 51A:2003;7-15
23. Kiefer R., Supler M.L., Toyka K.V., Streit W.J. In-situ detection of transforming growth-factor-beta messenger-RNA in experimental rat glioma and reactive glial-cells. Neurosci. Lett. 166:1994;161-164
24. Kielian T., van Rooijen N., Hickey W.F. MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo. J. Neuro-Oncol. 56:2002;1-12
25. Kruse C.A., Rubinstein D. Cytotoxic T-lymphocytes reactive to patient major histocompatibility complex proteins for therapy of brain tumors. Liau L.M., Becker D.P., Cloughesy T.F., Bigner D.D. Brain Tumor Immunotherapy. 2001;149-170 Humana Press, Totowa, NJ
26. Kruse C.A., Lillehei K.O., Mitchell D.H., Kleinschmidt-DeMasters B., Bellgrau D. Analysis of Interleukin-2 and various effector cell-populations in adoptive immunotherapy of 9L rat gliosarcoma-allogeneic cytotoxic T-lymphocytes prevent tumor take. Proc. Natl. Acad. Sci. U. S. A. 87:1990;9577-9581
27. Kruse C.A., Kong Q.Z., Schiltz P.M., Kleinschmidt-DeMasters B.K. Migration of activated lymphocytes when adoptively transferred into cannulated rat-brain. J. Neuroimmunol. 55:1994;11-21
28. Kruse C.A., Schiltz P.M., Bellgrau D., Kong Q.Z., Kleinschmidt-DeMasters B.K. Intracranial administrations of single or multiple source allogeneic cytotoxic T-lymphocytes. Chronic therapy for primary brain-tumors. J. Neuro-Oncol. 19:1994;161-168
29. Kruse C.A., Molleston M.C., Parks E.P., Schiltz P.M., Kleinschmidt-DeMasters B.K., Hickey W.F. A rat glioma model, CNS-1 with invasive characteristics similar to those of human gliomas - a comparison to 9L gliosarcoma. J. Neuro-Oncol. 22:1994;191-200
30. Kruse C.A., Cepeda L., Owens B., Johnson S.D., Stears J., Lillehei K.O. Treatment of recurrent glioma with intracavitary alloreactive cytotoxic T lymphocytes and interleukin-2. Cancer Immunol. Immunother. 45:1997;77-87
31. Lorusso L., Rossi M.L. The phagocyte in human gliomas. Ann. N. Y. Acad. Sci. 832:1997;405-425
32. Magnus T., Chan A., Grauer O., Toyka K.V., Gold R. Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation. J. Immunol. 167:2001;5004-5010
33. Magnus T., Chan A., Savill J., Tokya K.V., Gold R. Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications. J. Neuroimmunol. 130:2002;1-9
34. Morioka T., Baba T., Black K.L., Streit W.J. Immunophenotypic analysis of infiltrating leukocytes and microglia in an experimental rat glioma. Acta Neuropathol. 83:1992;590-597
35. Parney I.F., Hao C.H., Petruk K.C. Glioma immunology and immunotherapy. Neurosurgery. 46:2000;778-791
36. Paul D.B., Read S.B., Kulprathipanja N.V., Gomez G.G., Kleinschmidt-DeMasters B.K., Schiltz P.M., Kruse C.A. Gamma interferon transduced 9L gliosarcoma. Cytokine gene therapy and its relevance to cellular therapy with alloreactive cytotoxic T lymphocytes. J. Neuro-Oncol. 64:2003;89-99
37. Raza S.M., Lang F.F., Aggarwal B.B., Fuller G.N., Wildrick D.M., Sawaya R. Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis. Neurosurgery. 51:2002;2-12
38. Read S.B., Kulprathipanja N.V., Gomez G.G., Paul D.B., Winston K.R., Robbins J.M., Kruse C.A. Human alloreactive CTL interactions with gliomas and with those having upregulated HLA expression from exogenous IFN-gamma or IFN-gamma gene modification. J. Interferon Cytokine Res. 23:2003;379-393
39. Sawada M., Suzumura A., Hosoya H., Marunouchi T., Nagatsu T. Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia. J. Neurochem. 72:1999;1466-1471
40. Seguin R., Biernacki K., Prat A., Wosik K., Kim H.J., Blain M., McCrea E., Bar-Or A., Antel J.P. Differential effects of Th1 and Th2 lymphocyte supernatants on human microglia. Glia. 42:2003;36-45
41. Smith M.E. Phagocytic properties of microglia in vitro: implications for a role in multiple sclerosis and EAE. Microsc. Res. Tech. 54:2001;81-94
42. Streit W.J., Walter S.A., Pennell N.A. Reactive microgliosis. Prog. Neurobiol. 57:1999;563-581
43. Taniguchi Y., Ono K., Yoshida S., Tanaka R. Antigen-presenting capability of glial cells under glioma-harboring conditions and the effect of glioma-derived factors on antigen presentation. J. Neuroimmunol. 111:2000;177-185
44. Virasch N., Kruse C.A. Strategies using the immune system for therapy of brain tumors. Hematol. Oncol. Clin. North Am. 15:2001;1053-1071
45. Witting A., Muller P., Herrmann A., Kettenmann H., Nolte C. Phagocytic clearance of apoptotic neurons by microglia/brain macrophages in vitro: involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition. J. Neurochem. 75:2000;1060-1070