Thieno[2,3-b]pyridinones as antagonists on the glycine site of the N- methyl-D-aspartate receptor - Binding studies, molecular modeling and structure-activity-relationships

Scientia Pharmaceutica

Volumn 68, Issue 1, 2000, Pages 3-14

  Buchstaller, H P ^a,b   Siebert, C D ^b   Lyssy, R H ^b   Ecker, G ^c   Krug, M ^a   Berger, M L ^c   Gottschlich, R ^a   Noe, C R ^b,c  

^a MERCK KGAA   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Glycine binding site; NMDA receptor; QSAR; Thieno 2,3 b pyridinone

Indexed keywords

4 HYDROXY 5 PHENYLTHIENO[2,3 B]PYRIDINE 6(7H) ONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; THIENO[2,3 B]PYRIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

EID: 0034732233     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.aut-00-01     Document Type: Article

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