Effects of oxidized-low density lipoprotein on expression of urotensin II receptor GPR14 in rat aortic smooth muscle cells

National Medical Journal of China

Volumn 86, Issue 4, 2006, Pages 242-246

  Wang, Zhi Jian ^a   Ding, Wen Hui ^b   Shi, Li Bin ^b   Bu, Ding Fang ^b   Ren, Zi Wen ^b   Tang, Chao Shu ^b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b NONE

Author keywords

Lipoprotein, LDL; Myocyte, smooth muscle; Urotensin II

Indexed keywords

IODINE 125; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; RADIOLIGAND; UROTENSIN II;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA MEDIA; ARTERY INTIMA PROLIFERATION; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG POTENTIATION; INCUBATION TIME; LIGAND BINDING; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; UPREGULATION;

ANIMALS; AORTA, THORACIC; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; IODINE RADIOISOTOPES; LIPOPROTEINS, LDL; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UROTENSINS;

EID: 32244433861     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Coulouam Y, Lihrmann I, Jegou S, et al. Cloning of the cDNA encoding the urotensin II precurser in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc Natl Acad Sci USA, 1998, 95: 15803-15808.
2. Ames RS, Saran HM, Chambers JK, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature, 1999, 401: 282-286.
3. Douglas SA, Tayara L, Ohlstein EH. Congestive heart failure and expression of myocardial urotensin II. Lancet, 2002, 359: 1990-1997.
4. Chinese source. 2001, 17:155-157.
5. Watanabe T, Pakala R, Katagiri T, et al. Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells. Circulation, 2001, 104: 16-18.
6. Chen YH, Zhao MW, Yao WZ, et. al. The signal transduction pathway in the proliferation of airway smooth muscle cells induced by urotensin II. Chin Med J,2004,117:37-41.
7. Zhang Y, Li J, Chen J, et al. Effect of chronic hypoxia on contents of urotensin II and its functional receptors in rat myocardium. Heart Vessels, 2002, 16: 64-68.
8. Birker-Robaczewska M, Boukhadra C, Studer R, et al. The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma. J Recept Signal Transduct Res, 2003, 23: 289-305.
9. Chatterjee S. Role of oxidized human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation. Mol Cell Biochem, 1992, 111: 143-147.
10. i and DNA synthesis in rat aortic smooth muscle cells. Hypertension, 1997, 29: 326-333.
11. Koba S, Pakala R, Watanabe T, et al. Vascular smooth muscle proliferation: synergistic interaction between serotonin and low density lipoproteins. J Am Coll Cardiol, 1999, 34: 1644-1651.
12. Nickenig G, Sachinidis A, Michaelsen F, et al. Upregulation of vascular angiotensin II receptor gene expression by low-density lipoprotein in vascular smooth muscle cells. Circulation, 1997, 95: 473-478.
13. Steinberg D. Oxidized low density lipoprotein an extreme example of lipoprotein heterogeneity. Isr J Med Sci, 1996, 32:469-472.
14. Nickenig G, Sachinidis A, Seewald S, et al. Influence of oxidized low-density lipoprotein on vascular angiotensin II receptor expression. J Hypertens, 1997, 15: S27-S30.
15. Kathrin J, Scheidegger, Richard W, et al. Differential effects of low density lipoproteins on insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expression in vascular smooth muscle cells. J Biol Chem, 2000, 275: 26864-26869.