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Volumn 48, Issue 3, 1998, Pages 231-241

Progesterone receptor variants found in breast cells repress transcription by wild-type receptors

Author keywords

Dominant negative variants; Hormone dependence; Markers; Progesterone receptors; Splice variants

Indexed keywords

CELL NUCLEUS RECEPTOR; MESSENGER RNA; PROGESTERONE RECEPTOR;

EID: 0031947298     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005941117247     Document Type: Article
Times cited : (44)

References (45)
  • 1
    • 0025293539 scopus 로고
    • Progestin regulation of cellular proliferation
    • Clarke CL, Sutherland RL: Progestin regulation of cellular proliferation. Endocr Rev 11: 266-302, 1990
    • (1990) Endocr Rev , vol.11 , pp. 266-302
    • Clarke, C.L.1    Sutherland, R.L.2
  • 2
    • 0026636999 scopus 로고
    • The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer?
    • Horwitz KB: The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev 13: 146-163, 1992
    • (1992) Endocr Rev , vol.13 , pp. 146-163
    • Horwitz, K.B.1
  • 3
    • 0016830681 scopus 로고
    • Predicting response to endocrine therapy in human breast cancer: A hypothesis
    • Horwitz KB, McGuire WL, Pearson OH, Segaloff A: Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science 189: 726-727, 1975
    • (1975) Science , vol.189 , pp. 726-727
    • Horwitz, K.B.1    McGuire, W.L.2    Pearson, O.H.3    Segaloff, A.4
  • 4
    • 0021034680 scopus 로고
    • Progesterone receptors as a prognstic factor in stage II breast cancer
    • Clark GM, McGuire WL, Hubay CA: Progesterone receptors as a prognstic factor in stage II breast cancer. N Engl J Med 309: 1343-1347, 1983
    • (1983) N Engl J Med , vol.309 , pp. 1343-1347
    • Clark, G.M.1    McGuire, W.L.2    Hubay, C.A.3
  • 5
    • 0024119654 scopus 로고
    • Genomic organization of the human oestrogen receptor gene
    • Ponglikitmongkol M, Green S, Chambon P: Genomic organization of the human oestrogen receptor gene. EMBO J 7: 3383-3388, 1988
    • (1988) EMBO J , vol.7 , pp. 3383-3388
    • Ponglikitmongkol, M.1    Green, S.2    Chambon, P.3
  • 10
    • 0029026592 scopus 로고
    • Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells
    • Pfeffer U, Fecarotta E, Vivaldi G: Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res 55: 2158-2165, 1995
    • (1995) Cancer Res , vol.55 , pp. 2158-2165
    • Pfeffer, U.1    Fecarotta, E.2    Vivaldi, G.3
  • 12
    • 0028014597 scopus 로고
    • A and B forms of the androgen receptor are present in human genital skin fibroblasts
    • Wilson CM, McPhaul MJ: A and B forms of the androgen receptor are present in human genital skin fibroblasts. Proc Natl Acad Sci USA 91: 1234-1238, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1234-1238
    • Wilson, C.M.1    McPhaul, M.J.2
  • 13
    • 0342597380 scopus 로고
    • Deletion of the steroid binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: Evidence for further genetic heterogeneity in this syndrome
    • Brown TR, Lubahn DB, Wilson EM, Joseph DR, French FS, Migeon CJ: Deletion of the steroid binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: Evidence for further genetic heterogeneity in this syndrome. Proc Natl Acad Sci USA 85: 8151-8155, 1988
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8151-8155
    • Brown, T.R.1    Lubahn, D.B.2    Wilson, E.M.3    Joseph, D.R.4    French, F.S.5    Migeon, C.J.6
  • 15
    • 0029056558 scopus 로고
    • Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
    • Bamberger CM, Bamberger AM, deCastro M, Chrousos GP: Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 95: 2435-2441, 1995
    • (1995) J Clin Invest , vol.95 , pp. 2435-2441
    • Bamberger, C.M.1    Bamberger, A.M.2    DeCastro, M.3    Chrousos, G.P.4
  • 16
    • 0027232267 scopus 로고
    • Identification of the activation-labile gene: A single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes
    • Ashraf J, Thompson EB: Identification of the activation-labile gene: A single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. Mol Endocrinol 7: 631-642, 1993
    • (1993) Mol Endocrinol , vol.7 , pp. 631-642
    • Ashraf, J.1    Thompson, E.B.2
  • 17
    • 0029584593 scopus 로고
    • Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life?
    • Kastner P, Mark M, Chambon P: Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life? Cell 83: 859-869, 1995
    • (1995) Cell , vol.83 , pp. 859-869
    • Kastner, P.1    Mark, M.2    Chambon, P.3
  • 20
    • 0021070493 scopus 로고
    • In situ photolinked nuclear progesterone receptors of human breast cancer cells: Subunit molecular weights after transformation and translocation
    • Horwitz KB, Alexander PS: In situ photolinked nuclear progesterone receptors of human breast cancer cells: Subunit molecular weights after transformation and translocation. Endocrinology 113: 2195-2201, 1983
    • (1983) Endocrinology , vol.113 , pp. 2195-2201
    • Horwitz, K.B.1    Alexander, P.S.2
  • 21
    • 0025606850 scopus 로고
    • 5′-heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated 'C'-receptor and unique A-receptor messages
    • Wei LL, Gonzalez-Aller C, Wood WM, Horwitz KB: 5′-heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated 'C'-receptor and unique A-receptor messages. Mol Endocrinol 4: 1833-1840, 1990
    • (1990) Mol Endocrinol , vol.4 , pp. 1833-1840
    • Wei, L.L.1    Gonzalez-Aller, C.2    Wood, W.M.3    Horwitz, K.B.4
  • 22
    • 0025239785 scopus 로고
    • Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
    • Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P: Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9: 1603-1614, 1990
    • (1990) EMBO J , vol.9 , pp. 1603-1614
    • Kastner, P.1    Krust, A.2    Turcotte, B.3    Stropp, U.4    Tora, L.5    Gronemeyer, H.6    Chambon, P.7
  • 23
    • 0018926559 scopus 로고
    • Circannual rhythms in steroid concentration and nuclear binding in the chick oviduct
    • Spelsberg TC, Halberg F: Circannual rhythms in steroid concentration and nuclear binding in the chick oviduct. Endocrinology 107: 1234-1244, 1980
    • (1980) Endocrinology , vol.107 , pp. 1234-1244
    • Spelsberg, T.C.1    Halberg, F.2
  • 24
    • 0020160816 scopus 로고
    • Nonfunctioning progesterone receptors in the developed oviducts from estrogen-withdrawn immature chicks and in aged nonlaying hens
    • Boyd-Leinen FA, Fournier D, Thomas CS: Nonfunctioning progesterone receptors in the developed oviducts from estrogen-withdrawn immature chicks and in aged nonlaying hens. Endocrinology 111: 30-36, 1982
    • (1982) Endocrinology , vol.111 , pp. 30-36
    • Boyd-Leinen, F.A.1    Fournier, D.2    Thomas, C.S.3
  • 25
    • 0027722025 scopus 로고
    • The ontogeny of gene expression of progestin receptors in the female rat brain
    • Kalo J, Hirata S, Nozawa A, Mouri N: The ontogeny of gene expression of progestin receptors in the female rat brain. J Steroid Biochem Mol Biol 47: 173-182, 1993
    • (1993) J Steroid Biochem Mol Biol , vol.47 , pp. 173-182
    • Kalo, J.1    Hirata, S.2    Nozawa, A.3    Mouri, N.4
  • 26
    • 0028026693 scopus 로고
    • New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: Only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP
    • Sartorius CA, Groshong SD, Miller LA, Powell RP, Tung L, Takimoto GS, Horwitz KB: New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: Only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer Res 54: 3868-3877, 1994
    • (1994) Cancer Res , vol.54 , pp. 3868-3877
    • Sartorius, C.A.1    Groshong, S.D.2    Miller, L.A.3    Powell, R.P.4    Tung, L.5    Takimoto, G.S.6    Horwitz, K.B.7
  • 27
    • 0028073682 scopus 로고
    • A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform
    • Sartorius CA, Melville MY, Hovland AR, Tung L, Takimoto GS, Horwitz KB: A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. Mol Endocrinol 8: 1347-1360, 1994
    • (1994) Mol Endocrinol , vol.8 , pp. 1347-1360
    • Sartorius, C.A.1    Melville, M.Y.2    Hovland, A.R.3    Tung, L.4    Takimoto, G.S.5    Horwitz, K.B.6
  • 28
    • 0027427216 scopus 로고
    • Human progesterone receptor a form is a cell and promoter specific repressor of human progesterone receptor B function
    • Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP: Human progesterone receptor A form is a cell and promoter specific repressor of human progesterone receptor B function. Mol Endocrinol 7: 1244-1255, 1993
    • (1993) Mol Endocrinol , vol.7 , pp. 1244-1255
    • Vegeto, E.1    Shahbaz, M.M.2    Wen, D.X.3    Goldman, M.E.4    O'Malley, B.W.5    McDonnell, D.P.6
  • 29
    • 0027156480 scopus 로고
    • Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP
    • Sartorius CA, Tung L, Takimoto GS, Horwitz KB: Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem 5: 9262-9266, 1993
    • (1993) J Biol Chem , vol.5 , pp. 9262-9266
    • Sartorius, C.A.1    Tung, L.2    Takimoto, G.S.3    Horwitz, K.B.4
  • 30
    • 0028153752 scopus 로고
    • Evidence for the existence of a third progesterone receptor protein in human breast cancer cell line T47D
    • Wei LL, Miner R: Evidence for the existence of a third progesterone receptor protein in human breast cancer cell line T47D. Cancer Res 54: 340-343, 1994
    • (1994) Cancer Res , vol.54 , pp. 340-343
    • Wei, L.L.1    Miner, R.2
  • 33
    • 0022261138 scopus 로고
    • Evolution of the functional human β-actin gene and its multi-pseudogene family: Conservation of noncoding regions and chromosomal dispersion of pseudogenes
    • Sun-Yu N, Gunning P, Eddy R, Ponte P, Leavitt J, Shows T, Kedes L: Evolution of the functional human β-actin gene and its multi-pseudogene family: Conservation of noncoding regions and chromosomal dispersion of pseudogenes. Mol Cell Biol 5: 2720-2732, 1985
    • (1985) Mol Cell Biol , vol.5 , pp. 2720-2732
    • Sun-Yu, N.1    Gunning, P.2    Eddy, R.3    Ponte, P.4    Leavitt, J.5    Shows, T.6    Kedes, L.7
  • 34
    • 0016700864 scopus 로고
    • Detection of specific sequences among DNA fragments separated by gel electrophoresis
    • Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503-517, 1975
    • (1975) J Mol Biol , vol.98 , pp. 503-517
    • Southern, E.M.1
  • 35
    • 0025323132 scopus 로고
    • Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms
    • Kastner P, Bocquel MT, Turcotte B, Gamier JM, Horwitz KB, Chambon P, Gronemeyer H: Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms. J Biol Chem 265: 12163-12167, 1990
    • (1990) J Biol Chem , vol.265 , pp. 12163-12167
    • Kastner, P.1    Bocquel, M.T.2    Turcotte, B.3    Gamier, J.M.4    Horwitz, K.B.5    Chambon, P.6    Gronemeyer, H.7
  • 37
    • 0024440781 scopus 로고
    • The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
    • Tora L, Mullick A, Metzger D, Ponglikitmongkol M, Park I, Chambon P: The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J 8: 1981-1986, 1989
    • (1989) EMBO J , vol.8 , pp. 1981-1986
    • Tora, L.1    Mullick, A.2    Metzger, D.3    Ponglikitmongkol, M.4    Park, I.5    Chambon, P.6
  • 38
    • 0028961127 scopus 로고
    • Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line. MCF-7/ TAMR-1 compared to the parental MCF-7 cell line
    • Madsen MW, Reiter BE, Lykkesfeldt AE: Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line. MCF-7/ TAMR-1 compared to the parental MCF-7 cell line. Mol Cell Endocrinol 109: 197-207, 1995
    • (1995) Mol Cell Endocrinol , vol.109 , pp. 197-207
    • Madsen, M.W.1    Reiter, B.E.2    Lykkesfeldt, A.E.3
  • 39
    • 0027249002 scopus 로고
    • Steroid hormone receptors: Interaction with deoxyribonucleic acid and transcription factors
    • Truss M, Beato M: Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endoer Rev 14: 459-479, 1995
    • (1995) Endoer Rev , vol.14 , pp. 459-479
    • Truss, M.1    Beato, M.2
  • 41
    • 0030297246 scopus 로고    scopus 로고
    • Identification of novel exon-deleted progesterone receptor variant mRNAs in human breast tissue
    • Leygue E, Dotzlaw H, Watson PH, Murphy LC: Identification of novel exon-deleted progesterone receptor variant mRNAs in human breast tissue. Biochem Biophys Res Commun 228: 63-68, 1996
    • (1996) Biochem Biophys Res Commun , vol.228 , pp. 63-68
    • Leygue, E.1    Dotzlaw, H.2    Watson, P.H.3    Murphy, L.C.4
  • 42
    • 0022970314 scopus 로고
    • Role of steroid hormone receptors as prognostic factors in primary breast cancer
    • McGuire WL, Clark GM, Dressier LG, Owens MA: Role of steroid hormone receptors as prognostic factors in primary breast cancer. NCI Monogr 1: 19-23, 1986
    • (1986) NCI Monogr , vol.1 , pp. 19-23
    • McGuire, W.L.1    Clark, G.M.2    Dressier, L.G.3    Owens, M.A.4
  • 43
    • 0021692744 scopus 로고
    • The role of progestins and progesterone receptors in the treatment of breast cancer
    • Sedlacek SM, Horwitz KB: The role of progestins and progesterone receptors in the treatment of breast cancer. Steroids 44: 467-484, 1984
    • (1984) Steroids , vol.44 , pp. 467-484
    • Sedlacek, S.M.1    Horwitz, K.B.2
  • 45
    • 0028840057 scopus 로고
    • Editorial: When tamoxifen turns bad
    • Horwitz KB: Editorial: When tamoxifen turns bad. Endocrinology 136: 821-823, 1995
    • (1995) Endocrinology , vol.136 , pp. 821-823
    • Horwitz, K.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.