The induction of NOS2 expression by the hybrid cecropin A-melittin antibiotic peptide CA(1-8)M(1-18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1763, Issue 1, 2006, Pages 110-119

  Arias, Cristina ^a   Guizy, Miriam ^a   Luque Ortega, Juan R ^b   Guerrero, Esther ^b   De La Torre, Beatriz G ^c   Andreu, David ^c   Rivas, Luis ^b   Valenzuela, Carmen ^a  

^a Instituto Nacional de Toxicologia   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Antimicrobial peptide; Cecropin A melittin; Electrophysiology; Macrophage

Indexed keywords

CECROPIN A; DYE; FLUORESCEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LYSYLTRYPTOPHANYLLYSYLLEUCYLPHENYLALANYLLYSYLLYSYLISOLEUCYLGLYCYLISOLEUCYL GLYCYLALANYLVALYLLEUCYLLYSYLVALYLLEUCYLTHREONYLTHREONYLGLYCYL LEUCYLPROLYLALANYLLEUCYLISOLEUCYLSERINAMIDE; MELITTIN; NITRIC OXIDE; POLYPEPTIDE ANTIBIOTIC AGENT; TRITON X 100; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CELL LINE; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; ELECTROPHYSIOLOGY; GENE EXPRESSION; MACROPHAGE; MACROPHAGE ACTIVATION; MEMBRANE TRANSPORT; METABOLITE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; TOXICITY; VITAL STAIN;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; ELECTROPHYSIOLOGY; ENZYME INDUCTION; FLUORESCENT DYES; MELITTEN; MICE; MONOCYTES; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING;

ANIMALIA;

EID: 32144440641     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2005.11.003     Document Type: Article

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