Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 2005-2021

  Ohno, Michihiro ^a   Tanaka, Yoichiro ^a   Miyamoto, Mitsuko ^a   Takeda, Takahiro ^a   Hoshi, Kazuhiro ^a   Yamada, Naohiro ^a   Ohtake, Atsushi ^a  

^a TORAY INDUSTRIES INC   (Japan)

Author keywords

Anti thrombosis; Dual prostanoids; Prostacyclin; Thromboxane A2 antagonist

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3,4 DIHYDRO 2H BENZ[1,4]OXAZIN 8 YLOXYACETIC ACID DERIVATIVE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; 7,8 DIHYDRO 5 [2 [[ALPHA (3 PYRIDYL)BENZYLIDENE]AMINOOXY]ETHYL] 1 NAPHTHYLOXYACETIC ACID; [1 [2 (1,1 DIPHENYLETHYLSULFANYL)ETHYL] 2,3 DIHYDRO 1H INDOL 4 YLOXY]ACETIC ACID; [1 [2 (1,1 DIPHENYLETHYLTHIO)ETHYL] 1,2,3,4 TETRAHYDROQUINOLIN 5 YLOXY]ACETIC ACID; [1 [2 (1,1 DIPHENYLETHYLTHIO)ETHYL] 2,3,4,5 TETRAHYDRO 1H BENZAZEPIN 6 YLOXY]ACETIC ACID; [4 (4,4 DIPHENYLPENTYL) 8 HYDROXY 3 OXO 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1 METHYL 1 PHENYLETHYLTHIO)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1,1 BIS (3 THIENYL)ETHYLTHIO]ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1,1 DIPHENYL 2,2,2 TRIFLUOROETHYLTHIO)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1,1 DIPHENYLETHOXY)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1,1 DIPHENYLETHYLSULFINYL)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1,1 DIPHENYLETHYLTHIO)ETHYL] 3 OXODIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1,1 DIPHENYLETHYLTHIO)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (1,1 DIPHENYLETHYLTHIO)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID N METHYL D GLUCAMINE SALT; [4 [2 (2,2 DIPHENYLPROPYLTHIO)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (BENZYLTHIO)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 (DIPHENYLMETHYLTHIO)ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; [4 [2 [1,1 BIS (4 FLUOROPHENYL)ETHYLTHIO]ETHYL] 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 8 YLOXY]ACETIC ACID; ADENOSINE DIPHOSPHATE; BENZOXAZINE DERIVATIVE; BERAPROST; PROSTACYCLIN RECEPTOR; PROSTANOID RECEPTOR; SCAFFOLD PROTEIN; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART RATE; HUMAN; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; MONKEY; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

ANIMALS; BENZOXAZINES; BLOOD PLATELETS; CELL MEMBRANE; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; FIBRINOLYTIC AGENTS; HUMANS; MACACA FASCICULARIS; MALE; MOLECULAR STRUCTURE; RECEPTORS, EPOPROSTENOL; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32044440712     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.050     Document Type: Article

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