Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: Synthesis, structure-activity relationship, and evaluation of benzofuran derivatives

Journal of Medicinal Chemistry

Volumn 48, Issue 16, 2005, Pages 5279-5294

  Ohno, Michihiro ^a   Miyamoto, Mitsuko ^a   Hoshi, Kazuhiro ^a   Takeda, Takahiro ^a   Yamada, Naohiro ^a   Ohtake, Atsushi ^a  

^a TORAY INDUSTRIES INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (1,1 DIPHENYLETHYLSULFANYL)ETHYL] 2 HYDROXYMETHYLBENZOFURAN 7 YLOXY]ACETIC ACID DIETHANOLAMINE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; BENZOFURAN 7 YLOXYACETIC ACID DERIVATIVE; BENZOFURAN DERIVATIVE; PROSTACYCLIN; PROSTACYCLIN RECEPTOR; PROSTACYCLIN RECEPTOR AGONIST; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; EX VIVO STUDY; HOMEOSTASIS; HUMAN; HYPOTENSION; IN VITRO STUDY; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS PREVENTION; VASOCONSTRICTION;

ANIMALS; BENZOFURANS; BINDING SITES; BLOOD PRESSURE; FIBRINOLYTIC AGENTS; HEART RATE; HUMANS; MACACA FASCICULARIS; MALE; PLATELET AGGREGATION; RADIOLIGAND ASSAY; RECEPTORS, EPOPROSTENOL; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 23444442092     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050194z     Document Type: Article

References (21)

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