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Volumn 72, Issue 1, 2006, Pages 8-18

AIDS vaccine: Present status and future challenges

Author keywords

AIDS; Clinical trials; HIV; Obstacles; Vaccine

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; ENVELOPE PROTEIN; GLYCOPROTEIN GP 160; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN; NEUTRALIZING ANTIBODY; RECOMBINANT GLYCOPROTEIN GP 120; T LYMPHOCYTE RECEPTOR; VIRUS VACCINE; VIRUS VECTOR;

EID: 32044438197     PISSN: 03786323     EISSN: None     Source Type: Journal    
DOI: 10.4103/0378-6323.19711     Document Type: Review
Times cited : (2)

References (50)
  • 1
    • 0023890040 scopus 로고
    • Human antibody response to a strain-specific HIV-1 gp120 epitope associated with cell fusion inhibition
    • Goudsmit J, Boucher CA, Meloen RH, Epstein LG, Smit L, van der Hoek L, et al. Human antibody response to a strain-specific HIV-1 gp120 epitope associated with cell fusion inhibition. AIDS 1988;2:157-64.
    • (1988) AIDS , vol.2 , pp. 157-164
    • Goudsmit, J.1    Boucher, C.A.2    Meloen, R.H.3    Epstein, L.G.4    Smit, L.5    Van Der Hoek, L.6
  • 2
    • 0027256814 scopus 로고
    • Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
    • Thali M, Moore JP, Furman C, Charles M, Ho DD, Robinson J, et al. Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding. J Virol 1993;67:3978-88.
    • (1993) J Virol , vol.67 , pp. 3978-3988
    • Thali, M.1    Moore, J.P.2    Furman, C.3    Charles, M.4    Ho, D.D.5    Robinson, J.6
  • 3
    • 0034712874 scopus 로고    scopus 로고
    • Antibody and virus: Binding and neutralization
    • Burton DR, Williamson RA, Parren PW. Antibody and virus: binding and neutralization. Virology 2000;270:1-3.
    • (2000) Virology , vol.270 , pp. 1-3
    • Burton, D.R.1    Williamson, R.A.2    Parren, P.W.3
  • 4
    • 0019731145 scopus 로고
    • An analysis of effector T cell generation and function in mice exposed to influenza A or Sendai viruses
    • Ada G, Leung KN, Erti H. An analysis of effector T cell generation and function in mice exposed to influenza A or Sendai viruses. Immunol Rev 1981;58:5-24.
    • (1981) Immunol Rev , vol.58 , pp. 5-24
    • Ada, G.1    Leung, K.N.2    Erti, H.3
  • 5
    • 0020536915 scopus 로고
    • Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specific and H-2-restricted cytotoxic T lymphocytes
    • Sethi KK, Omata Y, Schneweis KE. Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specific and H-2-restricted cytotoxic T lymphocytes. J Gen Virol 1983;64:443-7.
    • (1983) J Gen Virol , vol.64 , pp. 443-447
    • Sethi, K.K.1    Omata, Y.2    Schneweis, K.E.3
  • 6
    • 0023676066 scopus 로고
    • Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion
    • Siliciano RF, Lawton T, Knall C, Karr RW, Berman P, Gregory T, et al. Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell 1988;54:561-75.
    • (1988) Cell , vol.54 , pp. 561-575
    • Siliciano, R.F.1    Lawton, T.2    Knall, C.3    Karr, R.W.4    Berman, P.5    Gregory, T.6
  • 7
    • 0028210969 scopus 로고
    • Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques
    • Reimann KA, Tenner RK, Racz P, Montefiori DC, Yasutomi Y, Lin W, et al. Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. J Virol 1994;68:2362-70.
    • (1994) J Virol , vol.68 , pp. 2362-2370
    • Reimann, K.A.1    Tenner, R.K.2    Racz, P.3    Montefiori, D.C.4    Yasutomi, Y.5    Lin, W.6
  • 8
    • 0033766645 scopus 로고    scopus 로고
    • Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    • Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Tong-Ming F, Wagner W, et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 2000;290:486-92.
    • (2000) Science , vol.290 , pp. 486-492
    • Barouch, D.H.1    Santra, S.2    Schmitz, J.E.3    Kuroda, M.J.4    Tong-Ming, F.5    Wagner, W.6
  • 10
    • 0027972391 scopus 로고
    • HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood
    • Clerici M, Levin JM, Kessler HA, Harris A, Berzofsky JA, Landay AL, et al. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. JAMA 1994;271:42-6.
    • (1994) JAMA , vol.271 , pp. 42-46
    • Clerici, M.1    Levin, J.M.2    Kessler, H.A.3    Harris, A.4    Berzofsky, J.A.5    Landay, A.L.6
  • 11
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 1995;332:228-32.
    • (1995) N Engl J Med , vol.332 , pp. 228-232
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Desrosiers, R.C.5
  • 13
    • 0027404328 scopus 로고
    • Augmentation of human immunodeficiency virus type1 neutralizing antibody by priming with gp160 recombinant vaccinia and boosting with rgp160 in vaccinianaive adults. The NIAID AIDS vaccine clinical trials network
    • Graham BS, Matthews TJ, Belshe RB, Clements ML, Dolin R, Wright PF, et al. Augmentation of human immunodeficiency virus type1 neutralizing antibody by priming with gp160 recombinant vaccinia and boosting with rgp160 in vaccinianaive adults. The NIAID AIDS vaccine clinical trials network. J Infect Dis 1993;167:533-7.
    • (1993) J Infect Dis , vol.167 , pp. 533-537
    • Graham, B.S.1    Matthews, T.J.2    Belshe, R.B.3    Clements, M.L.4    Dolin, R.5    Wright, P.F.6
  • 14
    • 0033527905 scopus 로고    scopus 로고
    • Development of bivalent (B/E) vaccines able to neutralize CCR5-dependent viruses from the United States and Thailand
    • Berman PW, Huang W, Riddle L, Gray AM, Wrin T, Vennari J, et al. Development of bivalent (B/E) vaccines able to neutralize CCR5-dependent viruses from the United States and Thailand. Virology 1999;265:1-9.
    • (1999) Virology , vol.265 , pp. 1-9
    • Berman, P.W.1    Huang, W.2    Riddle, L.3    Gray, A.M.4    Wrin, T.5    Vennari, J.6
  • 15
    • 19144365910 scopus 로고    scopus 로고
    • Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1
    • Mascola JR, Snyder SW, Weislow OS, Belay SM, Belshe RB, Schwartz DH, et al. Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. J Infect Dis 1996;173:340-8.
    • (1996) J Infect Dis , vol.173 , pp. 340-348
    • Mascola, J.R.1    Snyder, S.W.2    Weislow, O.S.3    Belay, S.M.4    Belshe, R.B.5    Schwartz, D.H.6
  • 16
    • 0030586434 scopus 로고    scopus 로고
    • Safety and immunogenicity of a candidate HIV-1 vaccine in healthy adults: Recombinant glycoprotein (rgp) 120 - A randomized, double-blind trial
    • Graham BS, Keefer MC, McElrath MJ, Gorse GJ, Schwartz DH, Weinhold K, et al. Safety and immunogenicity of a candidate HIV-1 vaccine in healthy adults: Recombinant glycoprotein (rgp) 120 - a randomized, double-blind trial. Ann Intern Med 1996;125:270-9.
    • (1996) Ann Intern Med , vol.125 , pp. 270-279
    • Graham, B.S.1    Keefer, M.C.2    McElrath, M.J.3    Gorse, G.J.4    Schwartz, D.H.5    Weinhold, K.6
  • 17
    • 0028024901 scopus 로고
    • Neutralizing antibodies to HIV-1 in seronegative volunteers immunized with recombinant gp120 from the MN strain of HIV-1. NIAID AIDS vaccine clinical trials network
    • Belshe RB, Graham BS, Keefer MC, Gorse GJ, Wright P, Dolin R, et al. Neutralizing antibodies to HIV-1 in seronegative volunteers immunized with recombinant gp120 from the MN strain of HIV-1. NIAID AIDS vaccine clinical trials network. JAMA 1994;272:475-80.
    • (1994) JAMA , vol.272 , pp. 475-480
    • Belshe, R.B.1    Graham, B.S.2    Keefer, M.C.3    Gorse, G.J.4    Wright, P.5    Dolin, R.6
  • 18
    • 17344365609 scopus 로고    scopus 로고
    • Cytotoxic T cell and neutralizing antibody responses to HIV-1 envelope with a combination vaccine regimen
    • Corey L, McElrath MJ, Weinhold K, Matthews T, Stablein D, Graham B, et al. Cytotoxic T cell and neutralizing antibody responses to HIV-1 envelope with a combination vaccine regimen. J Infect Dis 1998;177:301-9.
    • (1998) J Infect Dis , vol.177 , pp. 301-309
    • Corey, L.1    McElrath, M.J.2    Weinhold, K.3    Matthews, T.4    Stablein, D.5    Graham, B.6
  • 19
    • 10244263660 scopus 로고    scopus 로고
    • Antibody to native human immunodeficiency virus type 1 envelope glycoproteins induced by IIIB and MN recombinant gp120 vaccines
    • Gorse GJ, Patel GB, Newman FK. Antibody to native human immunodeficiency virus type 1 envelope glycoproteins induced by IIIB and MN recombinant gp120 vaccines. Clin Diag Lab Immunol 1996;3:378-86.
    • (1996) Clin Diag Lab Immunol , vol.3 , pp. 378-386
    • Gorse, G.J.1    Patel, G.B.2    Newman, F.K.3
  • 20
    • 7144259087 scopus 로고    scopus 로고
    • HIV-1 immune responses induced by canarypox (ALVAC)-gp160 MN, SF-2 rgp120, or both vaccines in seronegative adults
    • Clements-Mann ML, Matthews TJ, Weinhold K. HIV-1 immune responses induced by canarypox (ALVAC)-gp160 MN, SF-2 rgp120, or both vaccines in seronegative adults. J Infect Dis 1998;177:1230-46.
    • (1998) J Infect Dis , vol.177 , pp. 1230-1246
    • Clements-Mann, M.L.1    Matthews, T.J.2    Weinhold, K.3
  • 21
    • 0033496071 scopus 로고    scopus 로고
    • A canarypox vaccine expressing multiple HIV-1 genes given alone or with rgp120 elicits broad and durable CD8+ CTL responses in seronegative volunteers
    • Evans TG, Keefer MC, Weinhold KJ, Wolff M, Montefiori DM, Corse GJ, et al. A canarypox vaccine expressing multiple HIV-1 genes given alone or with rgp120 elicits broad and durable CD8+ CTL responses in seronegative volunteers. J Infect Dis 1999;180:290-98.
    • (1999) J Infect Dis , vol.180 , pp. 290-298
    • Evans, T.G.1    Keefer, M.C.2    Weinhold, K.J.3    Wolff, M.4    Montefiori, D.M.5    Corse, G.J.6
  • 22
    • 0027240086 scopus 로고
    • Persisting human immunodeficiency virus type 1 gp160-specific human T lymphocyte responses including CD8+ cytotoxic activity after receipt of envelope vaccines
    • El-Daher N, Keefer MC, Reichman RC, Dolin R, Roberts NJ. Persisting human immunodeficiency virus type 1 gp160-specific human T lymphocyte responses including CD8+ cytotoxic activity after receipt of envelope vaccines. J Infect Dis 1993;168:306-13.
    • (1993) J Infect Dis , vol.168 , pp. 306-313
    • El-Daher, N.1    Keefer, M.C.2    Reichman, R.C.3    Dolin, R.4    Roberts, N.J.5
  • 23
    • 0031037693 scopus 로고    scopus 로고
    • Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers
    • USA
    • Ferrari G, Humphrey W, McElrath MJ. Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers. Proc Natl Acad Sci USA 1997;94:1396-401.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 1396-1401
    • Ferrari, G.1    Humphrey, W.2    McElrath, M.J.3
  • 24
    • 0034073361 scopus 로고    scopus 로고
    • Resistance to human immunodeficiency virus type 1 in vitro as a surrogate of vaccine-induced protective immunity
    • Castillo RC, Arango-Jaramillo S, John R, Weinhold K, Kanki P, Carruth L, et al. Resistance to human immunodeficiency virus type 1 in vitro as a surrogate of vaccine-induced protective immunity. J Infect Dis 2000;181:897-903.
    • (2000) J Infect Dis , vol.181 , pp. 897-903
    • Castillo, R.C.1    Arango-Jaramillo, S.2    John, R.3    Weinhold, K.4    Kanki, P.5    Carruth, L.6
  • 25
    • 0028169641 scopus 로고
    • HIV-1 envelope-elicited neutralizing antibody titers correlate with protection and virus load in chimpanzees
    • Bruck C, Thiriart C, Fabry L, Francotte M, Pala P, Van Opstal O, et al. HIV-1 envelope-elicited neutralizing antibody titers correlate with protection and virus load in chimpanzees. Vaccine 1994;12:1141-8.
    • (1994) Vaccine , vol.12 , pp. 1141-1148
    • Bruck, C.1    Thiriart, C.2    Fabry, L.3    Francotte, M.4    Pala, P.5    Van Opstal, O.6
  • 26
    • 0037303113 scopus 로고    scopus 로고
    • Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus
    • Schmitz JE, Kuroda MJ, Santra S, Simon MA, Lifton MA, Lin W, et al. Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol 2003;77:2165-73.
    • (2003) J Virol , vol.77 , pp. 2165-2173
    • Schmitz, J.E.1    Kuroda, M.J.2    Santra, S.3    Simon, M.A.4    Lifton, M.A.5    Lin, W.6
  • 27
    • 0037069682 scopus 로고    scopus 로고
    • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
    • Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, et al. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature 2002;420:678-82.
    • (2002) Nature , vol.420 , pp. 678-682
    • Kwong, P.D.1    Doyle, M.L.2    Casper, D.J.3    Cicala, C.4    Leavitt, S.A.5    Majeed, S.6
  • 28
    • 0031749469 scopus 로고    scopus 로고
    • A role for carbohydrates in immune evasion in AIDS
    • Reitter JN, Means RE, Desrosiers RC. A role for carbohydrates in immune evasion in AIDS. Nat Med 1998;4:679-84.
    • (1998) Nat Med , vol.4 , pp. 679-684
    • Reitter, J.N.1    Means, R.E.2    Desrosiers, R.C.3
  • 30
    • 0037389643 scopus 로고    scopus 로고
    • Rapid evolution of the neutralizing antibody response to HIV type 1 infection
    • USA
    • Richman DD, Wrin T, Little SJ, Petropoulos CJ. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. Proc Natl Acad Sci USA 2003;100:4144-9.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 4144-4149
    • Richman, D.D.1    Wrin, T.2    Little, S.J.3    Petropoulos, C.J.4
  • 31
    • 0037317611 scopus 로고    scopus 로고
    • Alternative conformations of HIV-1 V3 loops mimic b hairpins in chemokines, suggesting a mechanism for coreceptor selectivity
    • Zolla-Pazner S, Sharon M, Kessier N, Levy R, Görlach M, Anglister J. Alternative conformations of HIV-1 V3 loops mimic b hairpins in chemokines, suggesting a mechanism for coreceptor selectivity. Structure 2003;11:225-36.
    • (2003) Structure , vol.11 , pp. 225-236
    • Zolla-Pazner, S.1    Sharon, M.2    Kessier, N.3    Levy, R.4    Görlach, M.5    Anglister, J.6
  • 32
    • 0036229473 scopus 로고    scopus 로고
    • Role of N-linked glycans in a human immunodeficiency virus envelope glycoprotein: Effects on protein function and the neutralizing antibody response
    • Quinones-Kochs MI, Buonocore L, Rose JK. Role of N-linked glycans in a human immunodeficiency virus envelope glycoprotein: effects on protein function and the neutralizing antibody response. J Virol 2002;76:4199-211.
    • (2002) J Virol , vol.76 , pp. 4199-4211
    • Quinones-Kochs, M.I.1    Buonocore, L.2    Rose, J.K.3
  • 33
    • 0037122719 scopus 로고    scopus 로고
    • Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
    • Shiver JW, Fu TM, Chen L, Casimiro DR, Davies ME, Evans RK, et al. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 2002;415:331-5.
    • (2002) Nature , vol.415 , pp. 331-335
    • Shiver, J.W.1    Fu, T.M.2    Chen, L.3    Casimiro, D.R.4    Davies, M.E.5    Evans, R.K.6
  • 34
    • 0036827959 scopus 로고    scopus 로고
    • Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination
    • Baig J, Levy DB, McKay PF, Schmitz JE, Santra S, Subbramanian RA, et al. Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination. J Virol 2002;76:1484-90.
    • (2002) J Virol , vol.76 , pp. 1484-1490
    • Baig, J.1    Levy, D.B.2    McKay, P.F.3    Schmitz, J.E.4    Santra, S.5    Subbramanian, R.A.6
  • 35
    • 17944369239 scopus 로고    scopus 로고
    • An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants
    • Rose NF, Marx PA, Luckay A, Nixon DF, Moretto WJ, Donahoe SM, et al. An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. Cell 2001;106:539-49.
    • (2001) Cell , vol.106 , pp. 539-549
    • Rose, N.F.1    Marx, P.A.2    Luckay, A.3    Nixon, D.F.4    Moretto, W.J.5    Donahoe, S.M.6
  • 36
    • 32044458895 scopus 로고    scopus 로고
    • A single VSV/SHIV immunization followed by one heterologous MVA/SHIV boost results in effective control of peak virus load after SHIV challenge
    • Ramsburg E, Rose NF, Mefford M, Haglund K, Buonocore L, Nixon DF, et al. A single VSV/SHIV immunization followed by one heterologous MVA/SHIV boost results in effective control of peak virus load after SHIV challenge. AIDS 2003;17:S117-24.
    • (2003) AIDS , vol.17
    • Ramsburg, E.1    Rose, N.F.2    Mefford, M.3    Haglund, K.4    Buonocore, L.5    Nixon, D.F.6
  • 37
    • 0033811377 scopus 로고    scopus 로고
    • Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids
    • Boyer JD, Cohen AD, Ugen KE, Edgeworth RL, Bennett M, Shah A, et al. Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids. AIDS 2000;14:1515-22.
    • (2000) AIDS , vol.14 , pp. 1515-1522
    • Boyer, J.D.1    Cohen, A.D.2    Ugen, K.E.3    Edgeworth, R.L.4    Bennett, M.5    Shah, A.6
  • 38
    • 0033766645 scopus 로고    scopus 로고
    • Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    • Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 2000;290:486-92.
    • (2000) Science , vol.290 , pp. 486-492
    • Barouch, D.H.1    Santra, S.2    Schmitz, J.E.3    Kuroda, M.J.4    Fu, T.M.5    Wagner, W.6
  • 39
    • 0036096976 scopus 로고    scopus 로고
    • Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization
    • Chakrabarti BK, Kong WP, Wu BY, Yang ZY, Friborg J, Ling X, et al. Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization. J Virol 2002;76:5357-68.
    • (2002) J Virol , vol.76 , pp. 5357-5368
    • Chakrabarti, B.K.1    Kong, W.P.2    Wu, B.Y.3    Yang, Z.Y.4    Friborg, J.5    Ling, X.6
  • 40
    • 0035341521 scopus 로고    scopus 로고
    • Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus type 1 vaccine with or without gp120: A phase 2 study in higher- And lower-risk volunteers
    • Belshe RB, Stevens C, Gorse GJ, Buchbinder S, Weinhold K, Sheppard H, et al. Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus type 1 vaccine with or without gp120: a phase 2 study in higher- and lower-risk volunteers. J Infect Dis 2001;183:1343-52.
    • (2001) J Infect Dis , vol.183 , pp. 1343-1352
    • Belshe, R.B.1    Stevens, C.2    Gorse, G.J.3    Buchbinder, S.4    Weinhold, K.5    Sheppard, H.6
  • 41
    • 0037470407 scopus 로고    scopus 로고
    • AIDS vaccine trial produces disappointment and confusion
    • Cohen J. AIDS vaccine trial produces disappointment and confusion. Science 2003;299:1290-1.
    • (2003) Science , vol.299 , pp. 1290-1291
    • Cohen, J.1
  • 42
    • 0033566813 scopus 로고    scopus 로고
    • Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment
    • Calarota SA, Leandersson AC, Bratt G, Hinkula J, Klinman M, Weinhold KJ, et al. Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. J Immunol 1999;163:2330-8.
    • (1999) J Immunol , vol.163 , pp. 2330-2338
    • Calarota, S.A.1    Leandersson, A.C.2    Bratt, G.3    Hinkula, J.4    Klinman, M.5    Weinhold, K.J.6
  • 43
    • 33748038811 scopus 로고    scopus 로고
    • Update on Mercks AIDS vaccine program
    • February April
    • Kahn P. Update on Mercks AIDS vaccine program. IAVI Report February April 2003.
    • (2003) IAVI Report
    • Kahn, P.1
  • 44
    • 2542468699 scopus 로고    scopus 로고
    • Present status of human HIV vaccine development
    • Quoted by Calarota SA, Weiner DB. Present status of human HIV vaccine development. AIDS 2003;17:S73-S84.
    • (2003) AIDS , vol.17
    • Calarota, S.A.1    Weiner, D.B.2
  • 45
    • 0036500532 scopus 로고    scopus 로고
    • Safety and immunogenicity of a high-titred canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022A
    • Gupta K, Hudgens M, Corey L, McElrath J, Weinhold K, Montefiori DC, et al. Safety and immunogenicity of a high-titred canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022A. J Acquir Immune Defic Syndr 2002;29:254-61.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 254-261
    • Gupta, K.1    Hudgens, M.2    Corey, L.3    McElrath, J.4    Weinhold, K.5    Montefiori, D.C.6
  • 46
    • 0037231506 scopus 로고    scopus 로고
    • Comparison between env-specific T-cell epitopic responses in HIV-1-uninfected adults immunized with combination of ALVAC-HIV (vCP205) plus or minus rgp160MN/LAI-2 and HIV-1-infected adults
    • Ratto-Kim S, Loomis-Price LD, Aronson N, Grimes J, Hill C, Williams C, et al. Comparison between env-specific T-cell epitopic responses in HIV-1-uninfected adults immunized with combination of ALVAC-HIV (vCP205) plus or minus rgp160MN/LAI-2 and HIV-1-infected adults. J Acquir Immune Defic Syndr 2003;32:9-17.
    • (2003) J Acquir Immune Defic Syndr , vol.32 , pp. 9-17
    • Ratto-Kim, S.1    Loomis-Price, L.D.2    Aronson, N.3    Grimes, J.4    Hill, C.5    Williams, C.6
  • 47
    • 0036135692 scopus 로고    scopus 로고
    • A DNA/MVA-based candidate human immunodeficiency virus vaccine induces multi-specific T cell responses in rhesus macaques
    • Wee EG, Patel S, McMichael AJ, Hanke T. A DNA/MVA-based candidate human immunodeficiency virus vaccine induces multi-specific T cell responses in rhesus macaques. J Gen Virol 2002;83:75-80.
    • (2002) J Gen Virol , vol.83 , pp. 75-80
    • Wee, E.G.1    Patel, S.2    McMichael, A.J.3    Hanke, T.4
  • 49
    • 0035815437 scopus 로고    scopus 로고
    • Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    • Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 2001;292:69-74.
    • (2001) Science , vol.292 , pp. 69-74
    • Amara, R.R.1    Villinger, F.2    Altman, J.D.3    Lydy, S.L.4    O'Neil, S.P.5    Staprans, S.I.6
  • 50
    • 0036229959 scopus 로고    scopus 로고
    • Heterologous prime-boost vaccination strategies for HIV-1: Augmenting cellular immune responses
    • Quoted
    • Quoted by Newman MJ. Heterologous prime-boost vaccination strategies for HIV-1: Augmenting cellular immune responses. Curr Opin Invest Drugs 2002;3:374-8.
    • (2002) Curr Opin Invest Drugs , vol.3 , pp. 374-378
    • Newman, M.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.