Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model

European Journal of Pharmacology

Volumn 531, Issue 1-3, 2006, Pages 183-186

  Degroot, Aldemar ^a   Nomikos, George G ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Animal model; Anxiety; Cognition; Muscarinic receptor; Transgenic mouse

Indexed keywords

MUSCARINIC M2 RECEPTOR; MUSCARINIC M4 RECEPTOR;

ANIMAL EXPERIMENT; ANXIETY; ANXIETY DISORDER; ARTICLE; BEHAVIOR; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; ELECTRIC SHOCK; GENE DELETION; KNOCKOUT MOUSE; LATENT PERIOD; LONG TERM MEMORY; MALE; MEMORY CONSOLIDATION; MOUSE; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; TRANQUILIZING ACTIVITY; WILD TYPE;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; ELECTROSHOCK; FEMALE; GENE DELETION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M4; TIME FACTORS;

EID: 32044432085     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.036     Document Type: Article

References (22)

1. M. Battaglia Beyond the usual suspects: a cholinergic route for panic attacks Mol. Psychiatry 7 2002 239 246
2. M. Battaglia, S. Bertella, A. Ogliari, L. Bellodi, and E. Smeraldi Modulation by muscarinic antagonists of the response to carbon dioxide challenge in panic disorder Arch. Gen. Psychiatry 58 2001 114 119
3. C.B. Brink, S.L. Viljoen, S.E. de Kock, D.J. Stein, and B.H. Harvey Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells Metab. Brain Dis. 19 2004 51 70
4. L. Dazzi, C. Motzo, A. Imperato, M. Serra, G.L. Gessa, and G. Biggio Modulation of basal and stress-induced release of acetylcholine and dopamine in rat brain by abecarnil and imidazenil, two anxioselective gamma-aminobutyric acidA receptor modulators J. Pharmacol. Exp. Ther. 273 1995 241 247
5. A. Degroot, and G.G. Nomikos Genetic deletion and pharmacological blockade of CB1 receptors modulates anxiety in the shock-probe burying test Eur. J. Neurosci. 20 2004 1059 1064
6. A. Degroot, and G.G. Nomikos Fluoxetine disrupts the integration between anxiety and aversive memories Neuropsychopharmacology 30 2005 391 400
7. A. Degroot, M. Wade, C. Salhoff, R.J. Davis, E.T. Tzavara, and G.G. Nomikos Exposure to an elevated platform increases plasma corticosterone and hippocampal acetylcholine in the rat: reversal by chlordiazepoxide Eur. J. Pharmacol. 493 2004 103 109
8. 2 muscarinic acetylcholine receptor knockout mice Proc. Natl. Acad. Sci. U. S. A. 96 1999 1692 1697
9. B. Li, E.G. Duysen, L.A. Volpicelli-Daley, A.I. Levey, and O. Lockridge Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice Pharmacol. Biochem. Behav. 74 2003 977 986
10. J. McGaughy, B.J. Everitt, T.W. Robbins, and M. Sarter The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins Behav. Brain Res. 115 2000 251 263
11. T. Ohnuki, and Y. Nomura Effects of selective muscarinic antagonists, pirenzepine and AF-DX 116, on passive avoidance tasks in mice Biol. Pharm. Bull. 19 1996 814 818
12. E. Perry, M. Walker, J. Grace, and R. Perry Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends Neurosci. 22 1999 273 280
13. C. Pesold, and D. Treit Excitotoxic lesions of the septum produce anxiolytic effects in the elevated plus-maze and shock-probe burying tests Physiol. Behav. 52 1992 37 47
14. A. Routtenberg Knockout mouse fault lines Nature 374 1995 314 315
15. M. Sarter, and J.P. Bruno Cognitive functions of cortical acetylcholine: toward a unifying hypothesis Brain Res. Brain Res. Rev. 23 1997 28 46
16. H. Sienkiewicz-Jarosz, A.I. Czlonkowska, M. Siemiatkowski, P. Maciejak, J. Szyndler, and A. Plaznik The effects of physostigmine and cholinergic receptor ligands on novelty-induced neophobia J. Neural. Transm. 107 2000 1403 1412
17. J.W. Smythe, D. Murphy, S. Bhatnagar, C. Timothy, and B. Costall The effects of intrahippocampal scopolamine infusions on anxiety in rats as measured by the black-white box test Brain Res. Bull. 45 1998 89 93
18. D. Treit, J.P.J. Pinel, and H.C. Fibiger Conditioned defensive burying: a new paradigm for the study of anxiolytic agents Pharmacol. Biochem. Behav. 15 1981 619 626
19. A. Tsuda, I. Yoshishige, and M. Tanaka The contrasting effects of diazepam and yohimbine on conditioned defensive burying in rats Psychobiology 16 1988 213 217
20. 4 muscarinic receptor knockout mice Mol. Psychiatry 8 2003 673 679
21. A.E. Van Der Zee, and P.G.M. Luiten Muscarinic acetylcholine receptors in the hippocampus, neocortex and amygdala: a review of immunocytochemical localization in relation to learning and memory Prog. Neurobiol. 58 1999 409 471
22. 1 receptors modulate anxiety-like behaviour and spontaneous working memory in mice Psychopharmacology 155 2001 58 68