The effects of intrahippocampal scopolamine infusions on anxiety in rats as measured by the black-white box test

Brain Research Bulletin

Volumn 45, Issue 1, 1998, Pages 89-93

  Smythe, James W ^a   Bhatnagar, Seema ^a,b   Murphy, Deborah ^a   Timothy, Carryl ^a   Costall, Brenda ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acetylcholine; Anxiety; Black white box; Hippocampus; Hypothalamic pituitary adrenal; Rat; Scopolamine

Indexed keywords

ACETYLCHOLINE; SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR; CHOLINERGIC RECEPTOR BLOCKING; CHOLINERGIC SYSTEM; DRUG EFFECT; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THETA RHYTHM;

ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; HIPPOCAMPUS; INFUSIONS, PARENTERAL; MALE; MODELS, PSYCHOLOGICAL; RATS; RATS, INBRED STRAINS; REACTION TIME; SCOPOLAMINE;

EID: 0031974769     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00311-0     Document Type: Article

References (37)

1. Acquas E., Wilson C., Fibiger H. C. Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release effects of novelty, habituation and fear . J. Neurosci. 16:1996;3089-3096.
2. Azmitia E. C., McNaughton N., Tsaltas L., Fillenz M., Gray J. A. Interactions between hippocampal serotonin and the pituitary-adrenal axis in the septal driving of hippocampal theta-rhythm. Neuroendocrinology. 39:1984;471-475.
3. Bhatnagar, S.; Costall, B.; Smythe, J. W. Hippocampal cholinergic blockade elevates stress-induced hypothalamic-pituitary-adrenal function. Brain Res. (in press).
4. Bland B. H. The physiology and pharmacology of hippocampal formation theta rhythms. Prog. Neurobiol. 26:1986;1-54.
5. Bland B. H., Colon L. V. Extrinsic and intrinsic properties underlying oscillations and synchrony in limbic cortex. Prog. Neurobiol. 41:1993;157-208.
6. Bray J. H., Maxwell S. E. Analyzing and interpreting significant MANOVAs. J. Educat. Res. 52:1982;340-367.
7. Calogero A., Kamilaris T., Gomez M., Johnson E., Tartaglia M., Gold P., Chrousos G. The muscarinic cholinergic agonist arecoline stimulates the rat hypothalamic-pituitary-adrenal axis through a centrally-mediated corticotrophin-releasing hormone-dependent mechanism. Endocrinology. 125:1989;2445-2453.
8. Costall B., Jones B. J., Kelly M. E., Naylor R. J., Tomkins D. M. Exploration of mice in a black and white test box Validation as a model of anxiety . Pharmacol. Biochem. Behav. 32:1989;777-785.
9. Costall B., Domeney A. M., Kelly M. E., Tomkins D. M., Naylor R. J., Wong E. H. F., Smith W. L., Whiting R. L., Eglen R. M. The effects of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety. Eur. J. Pharmacol. 234:1993;91-99.
10. Delacour J. A central activation role for the hippocampus A viewpoint . Neurosci. Res. Commun. 16:1995;1-10.
11. Dunnet S. B., Everitt B. J., Robbins T. W. The basal forebrain cortical cholinergic system Interpreting the functional consequences of excitotoxic lesions . Trends Neurosci. 14:1991;494-501.
12. Dutar P., Bassant M.-H., Senut M.-C., Lamour Y. The septohippocampal pathway Structure and function of a central cholinergic system . Physiol. Rev. 75:1995;393-427.
13. Feldman S., Weidenfeld J. Neural mechanisms involved in the corticosteroid feedback effects on the hypothalamo-pituitary-adrenocortical axis. Prog. Neurobiol. 45:1995;129-141.
14. Fibiger H. C. Cholinergic mechanisms in learning, memory, and dementia A review of recent evidence . Trends Neurosci. 14:1991;220-223.
15. Gilad G. M., Habey J. M., Gilad V. H. Presynaptic effects of glucocorticoids on dopaminergic and cholinergic synaptosomes. Implications for rapid endocrine-neuronal interactions in stress. Life Sci. 40:1987;2401-2408.
16. Gray J. A. The neuropsychology of anxiety. 1982;Oxford Univ. Press, Oxford.
17. Hasselmo M. E. Neuromodulation and cortical function Modelling the physiological basis of behavior . Behav. Brain Res. 67:1995;1-27.
18. Hasey G., Hanin I. Plasma corticosterone is increased and correlated with brain acetylcholine in physostigmine- but not in neostigmine-treated rats. Psychoneuroendocrinology. 15:1990;357-369.
19. Hess C., Blozovski D. Hippocampal muscarinic cholinergic mediation of spontaneous alternation and fear in the developing rat. Behav. Brain Res. 24:1987;203-214.
20. Imperato A., Puglisi-Allegra S., Casolini P., Zocchi A., Angelucci L. Stress-induced enhancement of dopamine and acetylcholine release in limbic structures Role of corticosterone . Eur. J. Pharmacol. 165:1989;337-338.
21. Inglis F. M., Fibiger H. C. Increases in hippocampal and frontal cortical acetylcholine release associated with presentation of sensory stimuli. Neuroscience. 66:1995;81-86.
22. Janowsky D. S., Risch S. C. Role of acetylcholine mechanisms in the affective disorders. Meltzer H. Y. Psychopharmacology The third generation of progress . 1987;527-533 Raven Press, New York.
23. Karczmar A. G. Cholinergic substrates of cognition and organism-environment interaction. Prog. Neuropsychopharmacol. Biol. Psychiatry. 19:1995;187-211.
24. Meaney M. J., O'Donnell D., Viau V., Bhatnagar S., Sarrieau A., Smythe J. W., Shanks N., Walker C. D. Corticosteroid receptors in the rat brain and pituitary during development and hypothalamic-pituitary-adrenal (HPA) function. McLaughlin P., Zagon I. Receptors and the developing nervous system. 1993;163-201 Chapman and Hill, London.
25. Mizuno T., Endo Y., Arita T., Kimura F. Acetylcholine release in the rat hippocampus as measured by the microdialysis method correlates with motor activity and exhibits a diurnal variation. Neuroscience. 44:1991;607-612.
26. Monmaur P., Collet A., Puma C., Frankel-Kohn L., Sharif A. Relations between acetylcholine release and electrophysiological characteristics of theta rhythm A microdialysis study in the urethane-anesthetized rat hippocampus . Brain Res. Bull. 42:1997;141-146.
27. Muir J. L., Dunnett S. B., Robbins T. W., Everitt B. J. Attentional functions of the forebrain cholinergic systems Effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task . Exp. Brain Res. 89:1992;611-622.
28. Murphy D., Costall B., Smythe J. W. Electrophysiological activity in the hippocampus is regulated by mineralocorticoid receptors in urethane-anaesthetized rats. Br. J. Pharmacol. (Suppl.). 120:1996;212P.
29. Murphy D., Costall B., Smythe J. W. Yohimbine's anxiogenic effect in the black-white box can be reduced by chlordiazepoxide Confirmation of test validity for rats . Br. J. Pharmacol. (Suppl.). 119:1996;63P.
30. Nilsson O. G., Kalen P., Rosengren E., Bjorklund A. Acetylcholine release in the rat hippocampus as studied by microdialysis is dependent on axonal impulse flow and increases during behavioural activation. Neuroscience. 36:1990;325-338.
31. Paxinos G., Watson C. The rat brain in stereotaxic coordinates, 2nd ed. 1986;Academic, Sydney.
32. Potter P. E., Thorne B., Gaugan C. Modulation of hippocampal norepinephrine release by cholinergic agonists is altered by AF64A lesion. Brain Res. Bull. 42:1997;153-160.
33. Rodgers R. J., Cole J. C. Effects of scopolamine and its quanternary analogue in the murine elevated plus-maze test of anxiety. Behav. Pharmacol. 6:1995;283-289.
34. Smythe J. W., Costall B. Cholinergic involvement in the expression of behavioural inhibition in infant rats. Brain Res. Assoc. Abstr. 14:1997;30.
35. Smythe J. W., Murphy D., Bhatnagar S., Timothy C., Costall B. Muscarinic antagonists are anxiogenic in rats tested in the black-white box. Pharmacol. Biochem. Behav. 54:1996;57-63.
36. Vinogradova O. S. Expression, control, and probable functional significance of the neuronal theta-rhythm. Prog. Neurobiol. 45:1995;523-583.
37. Young S. L., Bohenek D. L., Fanselow M. S. Scopolamine impairs acquisition and facilitates consolidation of fear conditioning Differential effects for tone versus context conditioning . Neurobiol. Learn. Mem. 63:1995;174-180.