Nitrous oxide depresses electroencephalographic responses to repetitive noxious stimulation in the rat

British Journal of Anaesthesia

Volumn 96, Issue 2, 2006, Pages 216-221

  LeDuc, M L ^a   Atherley, R ^a   Jinks, S L ^a   Antognini, J F ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anaesthesia; Anaesthetics gases, nitrous oxide; Monitoring, electroencephalography

Indexed keywords

ANESTHETIC AGENT; ISOFLURANE; NITROUS OXIDE; OXYGEN; PANCURONIUM;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; BLOOD PRESSURE; BONE SCREW; CONTROLLED STUDY; DRUG EFFICACY; ELECTRIC POTENTIAL; ELECTROENCEPHALOGRAPHY; ELECTROSTIMULATION; EVOKED RESPONSE; HYPERBARISM; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NEUROTRANSMISSION; NOCICEPTIVE STIMULATION; NONHUMAN; OXYGEN TENSION; PRESSURE CHAMBER; PRIORITY JOURNAL; RAT; SKULL; TAIL;

EID: 31744443390     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aei309     Document Type: Article

References (20)

1. Hornbein TF, Eger EI, Winter PM, et al. The minimum alveolar concentration of nitrous oxide in man. Anesth Analg 1982; 61: 553-6
2. Antognini JF, Lewis BK, Reitan JA. Hypothermia minimally decreases nitrous oxide anesthetic requirements. Anesth Analg 1994; 79: 980-2
3. Russell GB, Graybeal JM. Direct measurement of nitrous oxide MAC and neurologic monitoring in rats during anesthesia under hyperbaric conditions. Anesth Analg 1992; 75: 995-9
4. Gonsowski CT, Eger EI. Nitrous oxide minimum alveolar anesthetic concentration in rats is greater than previously reported. Anesth Analg 1994; 79: 710-2
5. Yli-Hankala A, Lindgren L, Porkkala T, et al. Nitrous oxidemediated activation of the EEG during isoflurane anaesthesia in patients. Br J Anaesth 1993; 70: 54-7
6. Inada T, Shingu K, Nakao S, et al. Effects of nitrous oxide on haemodynamic and electroencephalographic responses induced by tetanic electrical stimulation during propofol anaesthesia. Anaesthesia 1999; 54: 423-6
7. Hans P, Bonhomme V, Benmansour H, et al. Effect of nitrous oxide on the bispectral index and the 95% spectral edge frequency of the electroencephalogram during surgery. Anaesthesia 2001; 56: 999-1002
8. Barr G, Jakobsson JG, Owall A, et al. Nitrous oxide does not alter bispectral index: Study with nitrous oxide as sole agent and as an adjunct to i.v. anaesthesia. Br J Anaesth 1999; 82: 827-30
9. Sebel PS, Lang E, Rampil IJ, et al. A multicenter study of bispectral electroencephalogram analysis for monitoring anesthetic effect. Anesth Analg 1997; 84: 891-9
10. Barter L, Dominguez CL, Carstens E, et al. The effect of isoflurane and halothane on electroencephalographic activation elicited by repetitive noxious c-fiber stimulation. Neurosci Lett 2005; 382: 242-7
11. Orth M, Barter L, Dominguez C, et al. Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation. Br J Anaesth 2005; 95: 477-84
12. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med 1998; 4: 460-3
13. Yamakura T, Harris RA. Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 2000; 93: 1095-101
14. Sawamura S, Kingery WS, Davies MF, et al. Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. J Neurosci 2000; 20: 9242-51
15. Zhang C, Davies MF, Guo TZ, et al. The analgesic action of nitrous oxide is dependent on the release of norepinephrine in the dorsal horn of the spinal cord. Anesthesiology 1999; 91: 1401-7
16. Antognini JF, Chen XG, Sudo M, et al. Variable effects of nitrous oxide at multiple levels of the central nervous system in goats. Vet Res Commun 2001; 25: 523-38
17. Shimoji K, Matsuki M, Shimizu H, et al. Dishabituation of mesencephalic reticular neurons by anesthetics. Anesthesiology 1977; 47: 349-52
18. Steriade M. Arousal: Revisiting the reticular activating system. Science 1996; 272: 225-6
19. Gramm HJ, Zimmermann J, Meinhold H, et al. Hemodynamic responses to noxious stimuli in brain-dead organ donors. Intensive Care Med 1992; 18: 493-5
20. Anderson RE, Jakobsson JG. Entropy of EEG during anaesthetic induction: a comparative study with propofol or nitrous oxide as sole agent. Br J Anaesth 2004; 92: 167-70