Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass

British Journal of Anaesthesia

Volumn 96, Issue 2, 2006, Pages 179-185

  Takizawa, E ^a   Hiraoka, H ^a   Takizawa, D ^b   Goto, F ^b  

^a Saitama Cardiovascular and Pulmonary Centre ^*  (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Anaesthetics i.v., propofol, unbound fraction; Monitoring, bispectral index; Pharmacokinetics

Indexed keywords

BICARBONATE; FENTANYL; MANNITOL; PROPOFOL; VECURONIUM;

ADULT; AGED; ARTICLE; BISPECTRAL INDEX; BLOOD SAMPLING; BODY TEMPERATURE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG ERYTHROCYTE LEVEL; DRUG MECHANISM; ELECTROENCEPHALOGRAM; EQUILIBRIUM DIALYSIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PHASE PARTITIONING; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RADIAL ARTERY; RANDOMIZED CONTROLLED TRIAL;

EID: 31744440886     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aei293     Document Type: Article

References (30)

1. Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther 2002; 71: 115-21
2. Rolan PE. Plasma protein binding displacement interactions - why are they still regarded as clinically important? Br J Clin Pharmacol 1994; 37: 125-8
3. MacKichan JJ. Protein binding drug displacement interactions fact or fiction? Clin Pharmacokinet 1989; 16: 65-73
4. Sansom LN, Evans AM. What is the true clinical significance of plasma protein binding displacement interactions? Drug Saf 1995; 12: 227-33
5. Hiraoka H, Yamamoto K, Okano N, Morita T, Goto F, Horiuchi R. Changes in drug plasma concentrations of an extensively bound and highly extracted drug, propofol, in response to altered plasma binding. Clin Pharmacol Ther 2004; 75: 324-30
6. Takizawa D, Hiraoka H, Goto F, Yamamoto K, Horiuchi R. Human kidneys play an important role in the elimination of propofol. Anesthesiology 2005; 102: 327-30
7. Mazoit JX, Samii K. Binding of propofol to blood components: implications for pharmacokinetics and for pharmacodynamics. Br J Clin Pharmacol 1999; 47: 35-42
8. Knibbe CA, Zuideveld KP, DeJongh J, Kuks PF, Aarts LP, Danhof M. Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: A comparison between propofol 6% and propofol 1%. Clin Pharmacol Ther 2002; 72: 670-84
9. Hiraoka H, Yamamoto K, Miyoshi S, et al. Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain. Br J Clin Pharmacol 2005; 60: 176-82
10. Rampil IJ. A primer for EEG signal processing in anesthesia. Anesthesiology 1998; 89: 980-1002
11. Billard V, Gambus PL, Chamoun N, Stanski DR, Shafer SL. A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect. Clin Pharmacol Ther 1997; 61: 45-58
12. Glass PS, Bloom M, Kearse L, Rosow C, Sebel P, Manberg P. Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers. Anesthesiology 1997; 86: 836-47
13. Kearse LA Jr, Rosow C, Zaslavsky A, Connors P, Dershwitz M, Denman W. Bispectral analysis of the electroencephalogram predicts conscious processing of information during propofol sedation and hypnosis. Anesthesiology 1998; 88: 25-34
14. Bruhn J, Ropcke H, Rehberg B, Bouillon T, Hoeft A. Electroencephalogram approximate entropy correctly classifies the occurrence of burst suppression pattern as increasing anesthetic drug effect. Anesthesiology 2000; 93: 981-5
15. Yoshitani K, Kawaguchi M, Takahashi M, Kitaguchi K, Furuya H. Plasma propofol concentration and EEG burst suppression ratio during normothermic cardiopulmonary bypass. Br J Anaesth 2003; 90: 122-6
16. Hirschi M, Meistelman C, Longrois D. Effects of normothermic cardiopulmonary bypass on bispectral index. Eur J Anaesthesiol 2000; 17: 499-505
17. Wilkinson GR, Shand DG. Commentary: A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 1975; 18: 377-90
18. Okano N, Hiraoka H, Owada R, et al. Hepatosplanchnic oxygenation is better preserved during mild hypothermic than during normothermic cardiopulmonary bypass. Can J Anaesth 2001; 48: 1011-14
19. Engdahl O, Abrahams M, Bjornsson A, et al. Cerebrospinal fluid concentrations of propofol during anaesthesia in humans. Br J Anaesth 1998; 81: 957-9
20. Doyle PW, Matta BF. Burst suppression or isoelectric encephalogram for cerebral protection: Evidence from metabolic suppression studies. Br J Anaesth 1999; 83: 580-4
21. VanHemelrijck J, Tempelhoff R, White PF, Jellish WS. EEG-assisted titration of propofol infusion during neuroanesthesia: Effect of nitrous oxide. J Neurosurg Anesthesiol 1992; 4: 11-20
22. Schnider TW, Minto CF, Shafer SL, et al. The influence of age on propofol pharmacodynamics. Anesthesiology 1999; 90: 1502-16
23. Bauer M, Wilhelm W, Kraemer T, et al. Impact of bispectral index monitoring on stress response and propofol consumption in patients undergoing coronary artery bypass surgery. Anesthesiology 2004; 101: 1096-104
24. Kreuer S, Biedler A, Larsen R, Altmann S, Wilhelm W. Narcotrend monitoring allows faster emergence and a reduction of drug consumption in propofol-remifentanil anesthesia. Anesthesiology 2003; 99: 34-41
25. Olofsen E, Dahan A. The dynamic relationship between end-tidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge frequency of the electroencephalogram. Anesthesiology 1999; 90: 1345-53
26. Bruhn J, Bouillon TW, Shafer SL. Bispectral index (BIS) and burst suppression: Revealing a part of the BIS algorithm. J Clin Monit Comput 2000; 16: 593-6
27. Schmidlin D, Hager P, Schmid ER. Monitoring level of sedation with bispectral EEG analysis: Comparison between hypothermic and normothermic cardiopulmonary bypass. Br J Anaesth 2001; 86: 769-76
28. De Paepe P, Belpaire FM, Rosseel MT, Van Hoey G, Boon PA, Buylaert WA. Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. Anesthesiology 2000; 93: 1482-90
29. Scott JC, Cooke JE, Stanski DR. Electroencephalographic quantitation of opioid effect: Comparative pharmacodynamics of fentanyl and sufentanil. Anesthesiology 1991; 74: 34-42
30. Scott JC, Ponganis KV, Stanski DR. EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 1985; 62: 234-41