Breath acetone predicts plasma ketone bodies in children with epilepsy on a ketogenic diet

Nutrition

Volumn 22, Issue 1, 2006, Pages 1-8

  Musa Veloso, Kathy ^a   Likhodii, Sergei S ^b   Rarama, Exequiel ^c   Benoit, Stephanie ^d   Liu, Yeou Mei Christiana ^e   Chartrand, Dominic ^d   Curtis, Rosalind ^e   Carmant, Lionel ^d   Lortie, Anne ^d   Comeau, Felix J E ^c   Cunnane, Stephen C ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Alcohol Countermeasure Systems   (Canada)

^d UNIVERSITY OF MONTREAL   (Canada)

^e HOLLAND BLOORVIEW KIDS REHABILITATION HOSPITAL   (Canada)

Author keywords

Hydroxybutyrate; Acetoacetate; Breath acetone analyzer; Gas chromatography; Isopropanol

Indexed keywords

2 PROPANOL; 3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ACETONE; BIOLOGICAL MARKER; KETONE BODY;

ADOLESCENT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BREATH ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; EPILEPSY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; KETOACIDOSIS; KETOGENIC DIET; MALE; MEASUREMENT; PRIORITY JOURNAL; SCHOOL CHILD; SEIZURE; STATISTICAL ANALYSIS;

ADOLESCENT; ADULT; ANTICONVULSANTS; BIOLOGICAL MARKERS; BREATH TESTS; CHILD; CHROMATOGRAPHY, GAS; DIET; EPILEPSY; FEMALE; HUMANS; KETONE BODIES; KETONES; KETOSIS; MALE; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SEIZURES; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 31744439591     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2005.04.008     Document Type: Article

References (34)

1. P.R. Huttenlocher Ketonemia and seizures metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy Pediat Res 10 1976 536 540
2. B. Whedon, J.I. Sirven, J. O'Dwyer, M.R. Sperling Therapeutic serum beta-hydroxybutyrate levels in adult ketogenic diet patients Epilepsia 40 suppl 7 1999 221
3. D.L. Gilbert, P.L. Pyzik, J.M. Freeman The ketogenic diet seizure control correlates better with serum β-hydroxybutyrate than with urine ketones J Child Neurol 15 2000 787 790
4. A.S. Dekaban Plasma lipids in epileptic children treated with the high fat diet Arch Neurol 15 1966 177 184
5. R.M. Schwartz, S. Boyes, A. Aynsley-Green Metabolic effects of three ketogenic diets in the treatment of severe epilepsy Dev Med Child Neurol 31 1989 152 160
6. D.D. Fraser, S. Whiting, R.D. Andrew, E.A. Macdonald, K. Musa-Veloso, S.C. Cunnane Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet Neurology 60 2003 1026 1029
7. E.M. Bridge, L.V. Iob The mechanism of the ketogenic diet in epilepsy Johns Hopkins Med J 48 1931 373 389
8. J.M. Freeman, J.B. Freeman, M.T. Kelly The ketogenic diet a treatment for epilepsy 3rd ed 2000 Demos Publications New York
9. G. Freund The calorie deficiency hypothesis of ketogenesis tested in man Metabolism 14 1965 985 990
10. S. Livingston Dietary management of epilepsy C.C. Thomas Comprehensive management of epilepsy in infancy, childhood, and adolescence 1972 Springfield IL 378 405
11. R.M. Schwartz, J. Eaton, B.D. Bower, A. Aynsley-Green Ketogenic diets in the treatment of epilepsy short-term clinical effects Dev Med Child Neurol 31 1989 145 151
12. L. Laffel Ketone bodies a review of physiology, pathophysiology and application of monitoring to diabetes Diabetes Metab Res Rev 15 1999 412 426
13. S.S. Likhodii, K. Musa, S.C. Cunnane Breath acetone as a measure of systemic ketosis assessed in a rat model of the ketogenic diet Clin Chem 48 2000 115 120
14. K. Musa-Veloso, S.S. Likhodii, S.C. Cunnane Breath acetone is a reliable indicator of ketosis in adult volunteers consuming ketogenic meals Am J Clin Nutr 76 2002 65 70
15. K. Musa-Veloso, E. Rarama, F. Comeau, R. Curtis, S.C. Cunnane Epilepsy and the ketogenic diet Assessment of ketosis in children using breath acetone Pediatr Res 52 2002 443 448
16. Y. Harano, M. Ohtsuki, M. Ida Direct automated assay method for serum or urine levels of ketone bodies Clin Chim Acta 151 1985 177 183
17. J.M. Bland, D.O. Artman Statistical methods for assessing agreement between two methods of clinical measurement Lancet i 1986 307 310
18. M.J. Sulway, J.M. Malins Acetone in diabetic ketoacidosis Lancet 2 1970 736 740
19. O.E. Owen, V.E. Trapp, C.L. Skutches, M.A. Mozzoli, R.D. Hoeldtke, G. Boden, G.A. Reichard Acetone metabolism during diabetic ketoacidosis Diabetes 31 1982 242 248
20. S. Levey, O.J. Balchum, V. Medrano, R. Jung Studies of metabolic products in expired air II. Acetone J Lab Clin Med 63 1964 574 584
21. V.L. Brechner, R.W.M. Bethune Determination of acetone concentration in arterial blood by vapor phase chromatography of alveolar gas Diabetes 14 1965 663 665
22. C.N. Tassopoulos, D. Barnett, T.R. Fraser Breath acetone and blood sugar measurements in diabetes Lancet i 1969 1282 1286
23. O.E. Owen, S. Caprio, G.A. Reichard, M.A. Mozzoli, G. Boden, R.S. Owen Ketosis of starvation a revisit and new perspectives Clin Endocrinol Metab 12 1983 359 379
24. G.A. Reichard, A.C. Haff, C.L. Skutches, P. Paul, C.P. Holroyde, O.E. Owen Plasma acetone metabolism in the fasting human J Clin Invest 63 1979 619 626
25. S.S. Likhodii, W.M. Burnham Ketogenic diet does acetone stop seizures? Med Sci Monit 8 2002 HY19 HY24
26. J.M. Rho, G.D. Anderson, S.D. Donevan, H.S. White Acetoacetate, acetone, and dibenzylamine (a contaminant in L-(+)-β-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo Epilepsia 43 2002 358 361
27. J.M. Argiles Has acetone a role in the conversion of fat to carbohydrate in mammals? Trends Biochem Sci 11 1986 61 63
28. M.P. Kalapos Possible physiological roles of acetone metabolism in humans Med Hypotheses 53 1999 236 242
29. M.P. Kalapos On the mammalian acetone metabolism from chemistry to chemical implications Biochem Biophys Acta 1621 2003 122 139
30. T.D. Price, D. Rittenberg The metabolism of acetone I. Gross aspects of catabolism and excretion J Biol Chem 185 1950 449 459
31. W. Sakami, H. Rudney The metabolism of acetone and acetoacetate in the mammalian organism Brookhaven Symp Biol 5 1952 176 191
32. 14 by intact rats J Biol Chem 234 1959 27 30
33. J.R. Luick, A.L. Black, M.G. Simesen, M. Kametaka, D.S. Kronfeld Acetone metabolism in normal and ketotic cows J Dairy Sci 50 1967 544 549
34. A.L. Black, J.R. Luick, S.L. Lee, K. Knox Glucogenic pathway for acetone metabolism in the lactating cow Am J Physiol 222 1972 1575 1580