Insulin therapy, glycemic control, and cardiovascular risk factors in young Latin Americans with type 2 diabetes mellitus

Journal of Investigative Medicine

Volumn 54, Issue 1, 2006, Pages 20-31

  Avilés Santa, Larissa ^a,b   Salinas, Karin ^a   Adams Huet, Beverley ^b   Raskin, Philip ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Diabetes mellitus; Endothelium derived factors; Inflammation; Insulin resistance; Insulin therapy; Latin Americans; Obesity

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; HEMOGLOBIN A1C; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; BLOOD SAMPLING; BODY FAT; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIABETES CONTROL; DIABETIC PATIENT; FEMALE; HISPANIC; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; LABORATORY TEST; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; RISK FACTOR; URINARY EXCRETION; WAIST HIP RATIO;

EID: 31644444894     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2005.05012     Document Type: Article

References (53)

1. Greenland P, Knoll MD, Stamler J, et al. Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA 2003;290:891-7.
2. Khot UN, Khot MB, Bajzer CT, et al. Prevalence of conventional risk factors in patients with coronary artery disease. JAMA 2003;290:898-904.
3. Turner RC, Millns H, Neil HAW, et al. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS 23). BMJ 1998;316:823-8.
4. Stratton IM, Adler AI, Neil AW, et al. Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-12.
5. Sobel BE. Effects of glycemic control and other determinants on vascular disease in type 2 diabetes. Am J Med 2002;113 Suppl 6A:12-22.
6. Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 2002;287:2570-81.
7. Hayden JM, Reaven PD. Cardiovascular disease in diabetes mellitus type 2: a potential role for novel cardiovascular risk factors. Curr Opin Lipidol 2000;11:519-28.
8. Libby P. Atherosclerosis: the new view. Sci Am 2002;286:45-66.
9. Streja D, Cressey P, Rabkin SW. Association between inflammatory markers, traditional risk factors, and complications in patients with type 2 diabetes mellitus. J Diabetes Complications 2003;17:120-7.
10. Reusch JEB. Current concepts in insulin resistance, type 2 diabetes mellitus and the metabolic syndrome. Am J Cardiol 2002;90 Suppl:19G-26G.
11. Goldstein BJ. Insulin resistance at the core defect in type 2 diabetes mellitus. Am J Cardiol 2002;90 Suppl:3G-10G.
12. Haffner SM, Stern MP, Hazuda HP, et al. Cardiovascular risk factors in confirmed prediabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 1990;263:2893-8.
13. Haffner SM. Pre-diabetes, insulin resistance, inflammation and CVD risk. Diabetes Res Clin Pract Suppl 2003;Suppl 1:9-18.
14. Festa A, Hanley AJG, Tracy RP, et al. Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. Circulation 2003;108:1822-30.
15. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86.
16. Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA 2002;287:2563-9.
17. Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus in development and progression of diabetic nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study. JAMA 2003;290:2159-67.
18. Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: randomized prospective 6-year study. Diabetes Res Clin Pract 1995;28:103-17.
19. Kannel WB, McGee DL. Diabetes and cardiovascular disease: the Framingham study. JAMA 1979;241:2035-8.
20. Barrett-Connor E, Wingard DL. Sex differential in ischemic heart disease mortality in diabetics: a prospective population-based study. Am J Epidemiol 1983;118:489-96.
21. Barrett-Connor EL, Cohn BA, Wingard DL, Edelstein SL. Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. JAMA 1991;265:627-31.
22. Norris SL, de Guzmán M, Sobel E, et al. Risk factors and mortality among black, Caucasian, and Latina women with acute myocardial infarction. Am Heart J 1993;126:1312-9.
23. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2003;26 Suppl 1:S5-20.
24. Brodie D, Moscrip V, Hutcheon R. Body composition measurement: a review of hydrodensitometry, anthropometry and impedance methods. Nutrition 1998;14:296-310.
25. Heitmann BL. Evaluation of body fat estimated from body mass index, skinfolds and impedance: a comparative study. Eur J Clin Nutr 1990;44:831-7.
26. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-23.
27. Gaenzer H, Neumayr G, Marschang P, et al. Effect of insulin therapy on endothelium-dependent dilation in type 2 diabetes mellitus. Am J Cardiol 2002;89:431-4.
28. Dandona P, Aljada A, Mohanty P. The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm. Diabetologia 2002;45:924-9.
29. Dandona P, Aljada A, Bandyopadhyay A. The potential therapeutic role of insulin in acute myocardial infarction in patients admitted to intensive care and in those with unspecified hyperglycemia. Diabetes Care 2003;26:516-9.
30. Chaudhuri A, Janicke D, Wilson MF, et al. Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment elevation myocardial infarction. Circulation 2004;109:849-54.
31. De Mattia G, Bravi MC, Costanzo A, et al. Effects of insulin on in vitro vascular cell adhesion molecule-1 expression and in vivo soluble VCAM- release. Diabetologia 1999;42:1235-9.
32. Aljada A, Ghanim H, Saadeh R, Dandona P. Insulin inhibits NFκB and MCP-1 expression in human aortic endothelial cells. J Clin Endocrinol Metab 2001;86:450-3.
33. Matsumoto K, Nakamura H, Ueki Y, et al. Correction of hyperglycemia reduces insulin resistance and serum soluble E-selectin levels in patients with type 2 diabetes mellitus. Diabet Med 2001;18:224-8.
34. Ryysy L, Yki-Järvinen H. Improvement of glycemic control by 1 year of insulin therapy leads to a sustained decrease in sE-selectin concentrations in type 2 diabetes. Diabetes Care 2001;24:549-54.
35. Vehkavaara S, Yki-Järvinen H. 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes. Arterioscler Thromb Vasc Biol 2004;24:325-30.
36. Rao SV, Donahue M, Pi-Sunyer X, Fuster V. Obesity as a risk factor in coronary artery disease. Am Heart J 2001;142:1102-7.
37. Caballero AE. Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease. Obes Res 2003;11:1278-89.
38. Hsueh WA, Quiñones MJ. Role of endothelial dysfunction in insulin resistance. Am J Cardiol 2003;92 Suppl:10J-7J.
39. Caballero AE. Endothelial dysfunction, inflammation, and insulin resistance: a focus on subjects at risk of type 2 diabetes. Curr Diab Rep 2004;4:237-46.
40. Kinlay S, Libby P, Ganz P. Endothelial function and coronary artery disease. Curr Opin Lipidol 2001;12:383-9.
41. Festa A, D'Agostino Jr R, Williams K, et al. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes 2001;25:1407-15.
42. Lemieux I, Pascot A, Prud'homme D, et al. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol 2001;21:961-7.
43. Marfella R, Esposito K, Giunta R, et al. Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia. Circulation 2000;101:2247-51.
44. Jilma B, Dallinger S, Hergovich N, et al. Effects of hyperinsulinemia on plasma levels of circulating adhesion molecules. J Clin Endocrinol Metab 2000;85:1748-51.
45. Matsumoto K, Sera Y, Miyake S. Serum levels of adhesion molecules correlate with insulin resistance. Atherosclerosis 2002;161:243-4.
46. Targher G, Bonadonna RC, Alberiche M, et al. Relation between soluble adhesion molecules and insulin sensitivity in type 2 diabetic individuals: role of adipose tissue. Diabetes Care 2001;24:1961-6.
47. Hunt KJ, Williams K, Resendez RG, et al. All-cause and cardiovascular mortality among diabetic participants in the San Antonio Heart Study: evidence against the "Hispanic paradox." Diabetes Care 2002;25:1557-63.
48. Hunt KJ, Resendez RG, Williams K, et al. All-cause and cardiovascular mortality among Mexican-American and non-Hispanic White older participants in the San Antonio Heart Study-evidence against the "Hispanic paradox." Am J Epidemiol 2003;158:1048-57.
49. Lerman-Garber I, Villa AR, Caballero AE. Diabetes and cardiovascular disease. Is there a true Hispanic paradox? Rev Invest Clin 2004;56:282-96.
50. Goff DC, Ramsey DJ, Labarthe DR, Nichaman MZ. Greater case-fatality after myocardial infarction among Mexican Americans and women than among non-Hispanic whites and men: the Corpus Christi Heart Project. Am J Epidemiol 1994;139:474-83
51. Tortolero SR, Goff DC, Nichaman MZ, et al. Cardiovascular risk factors in Mexican-American and non-Hispanic white children: the Corpus Christi Heart Project. Circulation 1997;96:418-23.
52. Mitchell BD, Stern MP, Haffner SM, et al. Risk factors for cardiovascular mortality in Mexican Americans and non-Hispanic Whites: The San Antonio Heart Study. Am J Epidemiol 1990;131:423-33.
53. Haffner SM, Mykkänen L, Stern MP et al. Greater effect of diabetes on LDL size in women than in men. Diabetes Care 1994;17:1164-71