Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: A six-month longitudinal follow-up study

Annali dell'Istituto Superiore di Sanita

Volumn 41, Issue 2, 2005, Pages 217-222

  Visconti, Andrea ^a   Cotichini, Rodolfo ^b   Cannoni, Stefania ^a   Bocca, Beatrice ^c   Forte, Giovanni ^c   Ghazaryan, Anna ^a   Santucci, Simone ^a   D'Ippolito, Cristina ^b   Stazi, Maria Antonietta ^b   Salvetti, Marco ^a   Alimonti, Alessandro ^c   Ristori, Giovanni ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Centro Nazionale di Epidemiologia   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Chemical elements; First demyelinating episode; Multiple sclerosis; Oxidative stress; Serum

Indexed keywords

ALUMINUM; ANTIMONY; BARIUM; BERYLLIUM; BISMUTH; CADMIUM; CALCIUM; CHROMIUM; COBALT; COPPER; HYDROPEROXIDE; IRON; LEAD; LIPID PEROXIDE; LITHIUM; MAGNESIUM; MANGANESE; MERCURY; MOLYBDENUM; NICKEL; REACTIVE OXYGEN METABOLITE; SILICON; STRONTIUM; THALLIUM; TIN; TRACE ELEMENT; TUNGSTEN; VANADIUM; ZINC; ZIRCONIUM;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; ATOMIC EMISSION SPECTROMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATION; FEMALE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MALE; MASS SPECTROMETRY; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PATHOGENESIS; PHOTOMETRY; QUANTITATIVE ANALYSIS; SERUM; TIME;

ADULT; ANTIOXIDANTS; COHORT STUDIES; DEMYELINATING DISEASES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MASS SPECTROMETRY; METALS; MULTIPLE SCLEROSIS; OXIDANTS; OXIDATIVE STRESS; SILICON;

EID: 31644442798     PISSN: 00212571     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Perry G, Sayre LM, Atwood CS, Castellani RJ, Cash AD, Rottkamp CA, Smith MA. The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implication. CNS Drugs 2002;16:339-52.
2. Gilgun-Sherki J, Melamed E, Offen D. Oxidative stress induced neurodegenerative disease: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacol 2001;40:959-75.
3. Pearson HA, Robinson JE. The role of iron in host resistance. Adv Pediatr 1976;23:1-33.
4. Fabris N, Mocchegiani E. Zinc, human disease and aging. Aging 1995;7:77-93.
5. Chandra RK. Micronutrients and immune functions: an overview. Ann NY Acad Sci 1990;58:9-16.
6. Goldman M, Druet P, Gleichmann E. Th2 cells in systematic autoimmunity: insights from allogenic disease and chemically-induced autoimmunity. Immunol Today 1991;12:223-7.
7. LeVine SM. Iron deposits in multiple sclerosis and Alzheimer's disease brains. Brain Res 1997;760:298-303.
8. Fung YK, Meade AG, Rack EP, Blotcky AJ. Brain mercury in neurodegenerative disorders. J Clin Toxicol 1997;35:49-54.
9. Schiffer RB. Zinc and multiple sclerosis. Neurology 1994;44: 1987-8.
10. Clausen J, Jensen GE, Nielsen SA. Selenium in chronic neurologic diseases. Multiple sclerosis and Batten's disease. Biol Trace Elem Res 1988;15:179-203.
11. Forte G, Bocca B, Senofonte O, Petrucci F, Brusa L, Stanzione P, Zannino S, Violante N, Alimonti A, Sancesario G. Trace and major elements in whole blood, serum, cerebrospinal fluid and urine of patients with Parkinson's disease. J Neural Transm 2004;111:1031-40.
12. Scott GS, Spitsin SV, Kean RB, Mikheeva T, Koprowski H, Hooper DC. Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors. Proc Natl Acad Sci USA 2002;99:16303-8.
13. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, Van Den Noort S, Weinshenker BY, Wolinsky JS. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50(1):121-7.
14. Bocca B, Forte G, Petrucci F, Senofonte O, Violante N, Alimonti A. Development of methods for the quantification of essential and toxic elements in human biomonitoring. Ann Ist Super Sanità 2005;41(2):165-70.
15. Purdey M. Chronic barium intoxication disrupts sulphated proteoglycan synthesis: a hypothesis for the origins of multiple sclerosis. Med Hypotheses 2004;62:746-54.
16. Yasui M, Yase Y, Ando K, Adachi k, Mukoyama M, Ohsugi K. Magnesium concentration in brains from multiple sclerosis patients. Acta Neurol Scand 1990;81:197-200.
17. Rossier P, van Erven S, Wade DT. The effect of magnesium oral therapy on spasticity in a patient with multiple sclerosis. Eur J Neurol 2000;7:741-4.
18. Stokes L, Gordon J, Grafton G. Non-voltage-gated L-type Ca2+ channels in human T cells. J Biol Chem 2004;279:19566-73.
19. Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Gene regulation mediated by calcium signals in T lymphocytes. Nature Immunol 2001;2:316-24.
20. Boullerne AI, Nedelkoska L, Benjamin LA. Synergism of nitric oxide and iron in killing the transformed murine oligodendrocyte cell line N20:1. J Neurochem 1999;72(3):1050-60.
21. Zapadniuk BV. The incidence of multiple sclerosis and the content of cobalt, boron, zinc, manganese and molybdenum in the arable soils of different climatic zones of Ukraine. Lik Sprava 1992;1:111-3.
22. Patra RC, Swarp D, Senapati SK. Effect of cadmium on lipid peroxides and superoxide dimutasein hepatic renal and testicular tissue of rats. Vet Hum Toxicol 1999;41(2):65-7.
23. Sloot WN, Korf J, Koster JF, Dewit LEA, Gramsbergen JBP. Manganese-induced hydroxyl radical formation in rat striatum is not attenuated by dopamine depletion or iron chelation in vivo. Exp Neurol 1996;138:236-45.
24. Markovac J, Goldestein GW. Picomolar concentrations of lead stimulate brain protein kinase C. Nature 1988;334(6177):71-3.
25. Vladimirova O, Lu FM, Shawver L, Kalman B. The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls. Inflamm Res 1999;48(7):412-6.
26. Earl C, Chantry A, Mohammad N, Glynn P. Zinc ions stabilise the association of basic protein with brain myelin membranes. J Neurochem 1988;51:718-24.
27. Winchurch RA. Activation of thymocyte responses to interleukin-1 by zinc. Clinical Immunol Immunopathol 1988;47:174-80.