Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted γ-keto carboxylic acids

Journal of Medicinal Chemistry

Volumn 49, Issue 2, 2006, Pages 456-458

  Ma, Dawei ^a   Jiang, Yongwen ^a   Chen, Fangping ^b   Gong, Li Kun ^b   Ding, Ke ^a   Xu, Yong ^a   Wang, Renxiao ^a   Ge, Aihua ^a   Ren, Jin ^b   Li, Jingya ^b   Li, Jia ^b   Ye, Qizhuang ^b  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA KETO CARBOXYLIC ACID DERIVATIVE; GELATINASE A; GELATINASE B; ISOENZYME; MACROPHAGE ELASTASE; MATRIC METALLOPROTEINASE 26; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MATRIX METALLOPROTEINASE 16; MATRIX METALLOPROTEINASE INHIBITOR; TANOMASTAT; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HAMSTER; HYDROGEN BOND; IC 50; IN VIVO STUDY; LUNG EMPHYSEMA; MALE; NONHUMAN; PROTECTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CRICETINAE; ISOENZYMES; KETO ACIDS; MALE; MATRIX METALLOPROTEINASES; MESOCRICETUS; MODELS, MOLECULAR; PANCREATIC ELASTASE; PULMONARY EMPHYSEMA; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 31544461567     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051101g     Document Type: Article

References (17)

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