Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 2, 2006, Pages 219-226

  Dianzani, Chiara ^a,c   Collino, Massimo ^a   Gallicchio, Margherita ^a   Samaritani, Simona ^b   Signore, Giovanni ^b   Menicagli, Rita ^b   Fantozzi, Roberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c Department of Anatomy Pharmacology and Forensic Medicine ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYL 4,6 DIMETHOXY 1,3,5 TRIAZINE; 4,6 DIMETHOXY 1,3,5 TRIAZINE DERIVATIVE; ANTIINFLAMMATORY AGENT; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INTERLEUKIN 1BETA; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THROMBOCYTE ACTIVATING FACTOR; TRIAZINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL CULTURE; CELL INFILTRATION; CONCENTRATION RESPONSE; CULTURE MEDIUM; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; INFLAMMATION; PHAGOCYTE; POLYMORPHONUCLEAR CELL; QUANTITATIVE ANALYSIS; STRUCTURE ANALYSIS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANTI-INFLAMMATORY AGENTS; CELL ADHESION; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-1; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PLATELET ACTIVATING FACTOR; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE; TRIAZINES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 31544453941     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.2.0009     Document Type: Article

References (30)

1. Altieri, D. C., Agbanyo, F. R., Plescia, J., Ginsberg, M. H., Edgington, T. S., Plow, E. F. J. (1990) A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1(CD11b/CD18). J. Biol. Chem. 265: 12119-12122
2. Avanzi, G. C., Gallicchio, M., Bottarel, F., Gammaitoni, L., Cavalloni, G., Buonfiglio, D., Bragardo, M., Bellomo, G., Albano, E., Fantozzi, R., Garbarino, G., Varnum, B., Aglietta, M., Saglio, G., Dianzani, U., Dianzani, C. (1998) GAS6 inhibits granulocyte adhesion to endothelial cells. Blood 91: 2334-2340
3. Berton, G., Lowell, C. A. (1999) Integrin signaling in neutrophils and macrophages. Cell Signal. 11: 621-635
4. Bussolino, F., Camussi, G. (1995) Platelet-activating factor produced by endothelial cells. A molecule with autocrine and paracrine properties. Eur. J. Biochem. 229: 327-337
5. Choi, J. S., Choi, Y. J., Park, S. H., Kang, J. S., Kang, Y. H. (2004) Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B. J. Nutr. 134: 1013-1019
6. Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., Barnathan, E. S., McCrae, K. R., Hug, B. A., Schmidt, A. M., Stern, D. M. (1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91: 3527-3561
7. Dalton, T. P., Shertzer, H. G., Puga, A. (1999) Regulation of gene expression by reactive oxygen. Annu. Rev. Pharmacol. Toxicol. 39: 67-101
8. D'Atri, G., Gomarasca, P., Resnati, G., Tronconi, G., Scolastico, C., Sirtori, C. R. (1984) Novel pyrimidine and 1,3,5-triazine hypolipemic agents. J. Med. Chem. 27: 1621-1629
9. Dhainaut, A., Regnier, G., Atassi, G., Pierre, A., Leonce, S., Kraus-Berthier, L., Prost, J. F. (1992) New triazine derivatives as potent modulators of multidrug resistance. J. Med. Chem. 35: 2481-2496
10. Dianzani, C., Brunelleschi, S. M., Viano, I., Fantozzi, R. (1994) Adenosine modulation of primed human neutrophils. Eur. J. Pharmacol. 263: 223-226
11. Dianzani, C., Parrini, M., Ferrara, C., Fantozzi, R. (1996) Effect of 4-hydroxynonenal on superoxide anion production from primed human neutrophils. Cell Biochem. Funct. 14: 193-200
12. Dianzani, C., Collino, M., Lombardi, G., Garbarino, G., Fantozzi, R. (2003) Substance P increases neutrophil adhesion to human umbilical vein endothelial cells. Br. J. Pharmacol. 139: 1103-1110
13. Jabs, T. (1999) Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem. Pharmacol. 57:231-245
14. Jang Y., Lincoff, A. M., Plow, E. F.. Topol, E. J. (1994) Cell adhesion molecules in coronary artery disease. J. Am. Coll. Cardiol. 24:1591-1561
15. Klenke, B., Stewart, M., Barrett, M. P., Brun, R., Gilbert, I. H. (2001) Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. J. Med. Chem. 4: 3440-3452
16. Kukla, M. J., Ludovici, D. W., Janssen, P. A. J., Heeres, J., Moereels, H. E. L. (1998) Substituted diamino-1,3,5-triazine derivatives. European Patent Application EP 0 834 507 A1 Chem. Abstr. 128: 257449f
17. Li, H., Cybulski, M. I., Gimbrone, M. A., Libby, P. (1993) An atherogenic diet rapidly induce VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Atherioscler. Thromb. 13: 197-204
18. Lucchesi, B. R. (1990) Modulation of leukocyte-mediated myocardial reperfusion injury. Annu. Rev. Physiol. 52: 561-576
19. Menicagli, R., Samaritani, S., Signore, G., Vaglini, F., Dalla Via, L. (2004) In vitro cytotoxic activities of 2-alkyl-4,6-diheteroalkyl-1,3,5- triazines: new molecules in anticancer research. J. Med. Chem. 47: 4649-4652
20. Muller, W. A. (2002) Leukocyte-endothelial cell interactions in the inflammatory response. Lab Invest. 82: 521-533
21. Nick, J. A., Avdi, N. J., Young, S. K., Knall, C., Gerwins, P., Johnson, G. L., Worthen, G. S. (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J. Clin. Invest. 99: 975-986
22. Porter, J. R., Archibald, S. C., Brown, J. A., Childs, K., Critchley, D., Head, J. C., Hutchinson, B., Parton, T. A. H., Robinson, M. K., Shock, A., Warrellow, J., Zomaya, A. (2002) Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists. Bioorg. Med. Chem. Lett. 12: 1591-1594
23. Samaritani, S., Signore, G., Malanga, C., Menicagli R. (2005) Organometallic alkylation of 2-chloro-4,6-dimethoxy-1,3,5-triazine: a study. Tetrahedron 61: 4475-4483
24. Springer, T. A. (1994) Traffic signals for lymphocyte recirculation and leucocyte emigration: the multistep paradigm. Cell 76: 301-304
25. Tonnesen, M. G., Smedly, L. A., Henson, P. M. (1984) Neutrophil- endothelial cell interactions. Modulation of neutrophils adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl- phenylalanine in vitro. J. Clin. Invest. 74:1581-1592
26. Ulbrich, H., Eriksson, E. E., Lindbom, L. (2003) Leucocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends Pharmacol. Sci. 24: 640-647
27. Wang, Q., Liu, G., Shao, R., Huang, R. (2003) Synthesis and antivirus activity of 1,3,5-triazine derivatives. Heteroatom. Chem. 14: 542-545
28. Yang, Y. Y., Hu, C. J., Chang, S. M., Tai, T. Y., Leu, S. J. (2004) Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells. Atherosclerosis 174: 207-213
29. Zimmerman, G. A., McIntire, T. M., Prescott, S. M. (1985) Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J. Clin. Invest. 76: 2235-2246
30. Zimmerman, B. J., Anderson, D. C., Granger, D. N. (1992) Neuropeptides promote neutrophil adherence to endothelial cell monolayers. Am. J. Physiol. 263: G678-G682