An oral load of the early glycation compound lactuloselysine fails to accumulate in the serum of uraemic patients

Nephrology Dialysis Transplantation

Volumn 21, Issue 2, 2006, Pages 383-388

  Schwenger, Vedat ^a   Morath, Christian ^a   Schönfelder, Kathrin ^c   Klein, Wolfgang ^a   Weigel, Kai ^c   Deppisch, Reinhold ^b   Henle, Thomas ^c   Ritz, Eberhard ^a   Zeier, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Gambro Corporate Research   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Advanced glycation end products (AGEs); Furosine; Lactuloselysine; Nutrition; Renal failure

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMINO ACID; FUROSINE; LACTULOSELYSINE; LYSINE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID BLOOD LEVEL; ARTICLE; BIOACCUMULATION; CLINICAL ARTICLE; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; CONTROLLED STUDY; DIETARY INTAKE; GLYCATION; HUMAN; HYDROLYSIS; KIDNEY FAILURE; LOADING TEST; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; UREMIA; URINARY EXCRETION;

ADMINISTRATION, ORAL; GLYCOSYLATION; HUMANS; KIDNEY FAILURE; LACTULOSE; PERITONEAL DIALYSIS, CONTINUOUS AMBULATORY; UREMIA;

EID: 31544437158     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfi151     Document Type: Article

References (18)

1. Ledl F, Schleicher E. New aspects of the Maillard reaction in food and in the human body. Angew Chem Int Ed Engl 1990; 29: 565-594
2. Vlassara H. The AGE-receptor in the pathogenesis of diabetic complications. Diabetes Metab Res Rev 2001; 17: 436-443
3. Friedman EA. Advanced glycation end-products in diabetic nephropathy. Nephrol Dial Transplant 1999; 14 [Suppl 3]: 1-9
4. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-820
5. Miyata T, Wada Y, Cai Z et al. Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure. Kidney Int 1997; 51: 1170-1181
6. Henle T, Miyata T. Advanced glycation end products in uremia. Adv Ren Repl Ther 2003; 10: 321-331
7. Koschinsky T, He CJ, Mitsuhashi T et al. Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci USA 1997; 94: 6474-6479
8. Uribarri J, Peppa M, Cai W et al. Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients. Am J Kidney Dis 2003; 42: 532-538
9. Vlassara H, Cai W, Crandall J et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA 2002; 99: 15596-15601
10. Friedman M. Food browning and its prevention. J Agric Food Chem 1996; 44: 631-653
11. Wu YC, Monnier V, Friedlander M. Reliable determination of furosine in human serum and dialysate proteins by high-performance liquid chromatography. J Chromatogr B Biomed Appl 1995; 667: 328-332
12. Krause R, Knoll K, Henle T. Studies in the formation of furosine and pyridosine during acid hydrolysis of different Amadori Products of lysine. Eur Food Res Technol 2003; 216: 277-283
13. Resmini P, Pellegrino L, Masotti F, Tirelli A, Prati F. Detection of reconstituted milk powder in raw and in pasteurized milk by HPLC of furosine. Scienza e Tecnica Lattiero-Casearia 1992; 43: 169-186
14. Henle T, Walter H, Klostermeyer H. Evaluation of the extent of the early Maillard-reaction in milk products by direct measurement of the Amadori-product lactuloselysine. Z Lebensm Unters Forsch 1991; 193: 119-122
15. Henle T. AGES in foods: Do they play a role in uremia? Kidney Int Suppl 2003; s145-147
16. Faist V, Erbersdobler HF. Metabolic transit and in vivo effects of melanoidins and precursor compounds deriving from the Maillard reaction. Ann Nutr Metab 2001; 45: 1-12
17. Delpierre G, Collard F, Fortpied J, Van Schaftingen E. Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes. Biochem J 2002; 365: 801-808
18. Delpierre G, Van Schaftingen E. Fructosamine 3-kinase, an enzyme involved in protein deglycation. Biochem Soc Trans 2003; 31: 1354-1357